Results 51 to 60 of about 4,254 (195)

A novel ABCC6 variant causative of pseudoxanthoma elasticum [PDF]

, 2019
Pseudoxanthoma elasticum is an autosomal recessive heritable disorder caused by mutations in ABCC6. We describetwo siblings showing typical skin lesions and a clinical diagnosis of pseudoxanthoma elasticum.
Hladnik U, Fabiani F, Enzo MV, NISTICO' SP, Contrò G, Colao E, Dattilo V, Dastoli S, Tallerico R, Perrotti N, Iuliano R.   +10 more
core   +1 more source

Periumbilical perforating pseudoxanthoma elasticum [PDF]

, 2016
A 50-year-old woman presented with a 2-year history of a yellowish plaque studded with red brown keratotic papules in the periumbilical region. Histopathological examination from the yellow plaque showed curled and granular elastic fibers in the mid and ...
Kumar, Piyush, Savant, Sushil S, Barkat, Rizwana   +2 more
core   +1 more source

A New Zebrafish Model for Pseudoxanthoma Elasticum

Frontiers in Cell and Developmental Biology, 2021
Calcification of various tissues is a significant health issue associated with aging, cancer and autoimmune diseases. There are both environmental and genetic factors behind this phenomenon and understanding them is essential for the development of ...
Dávid Czimer, Klaudia Porok, Dániel Csete, Zsolt Gyüre, Viktória Lavró, Krisztina Fülöp, Zelin Chen, Hella Gyergyák, Gábor E. Tusnády, Shawn M. Burgess, Attila Mócsai, András Váradi, Máté Varga   +12 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, Volume 16, Issue 3, Page 474-486, March 2026.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

ABCC6 and pseudoxanthoma elasticum [PDF]

Pflügers Archiv - European Journal of Physiology, 2006
ABCC6 belongs to the adenosine triphosphate-binding cassette (ABC) gene subfamily C. This protein family is involved in a large variety of physiological processes, such as signal transduction, protein secretion, drug and antibiotic resistance, and antigen presentation [Kool et al. (1999) 59:175-182; Borst and Elferink (2002) 71:537-592].
Bergen, A.A.B., Plomp. A.S., [No Value], Hu, X., de Jong, P.T.V.M., Gorgels, Th.G.M.F.   +4 more
openaire   +3 more sources

Gram‐Scale Synthesis of an Arylsulfonamide‐Type Alkaline Phosphatase Inhibitor

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A larger amount of a tissue‐nonspecific alkaline phosphatase inhibitor, 5‐((5‐chloro‐2‐methoxyphenyl)sulfonamido)nicotinamide, was synthesized in five steps using a parallel method without the need for chromatography or crystallization. Because a single batch was used for in vivo studies in a large population of mice, the pharmacological results were ...
Zsolt Rapi, Krisztina Fülöp, Zoltán Mucsi   +2 more
wiley   +1 more source

A case series of pseudoxanthoma elasticum-like disorders

Indian Journal of Dermatology, 2019
Pseudoxanthoma elasticum (PXE)-like papillary dermal elastolysis and focal dermal elastosis are acquired noninflammatory elastic tissue disorders. The skin lesions clinically resemble PXE without systemic involvement.
Sarah Bandar Aljoudi, Mohammed Haithm Abduljabbar, Jehad Osama Hariri   +2 more
doaj   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Consensus Statement on Precision Anatomy and Treatment Strategies for Median Arcuate Ligament Syndrome: AOB Consensus Meeting

Asian Journal of Endoscopic Surgery, Volume 19, Issue 1, January/December 2026.
ABSTRACT Background With the increasing use of minimally invasive surgery, understanding of the precise anatomy involved in median arcuate ligament syndrome (MALS) has advanced. However, surgical strategies and treatment principles for MALS remain unclear.
Hidenori Haruta, Masaharu Higashida, Katsuyuki Hoshina, Toshio Takayama, Tomotaka Ueno, Saya Chiba, Noboru Ideno, Naoki Ikenaga, Shunji Endo, Yasunaru Sakuma, Toshiya Abe, Kenoki Ouchida, Masafumi Nakamura, Yuko Kitagawa, Akiko Umezawa   +14 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source