Results 51 to 60 of about 850,964 (168)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Psilocybin-Assisted Therapy: A Double-Blind Randomized Controlled Trial [PDF]
, 2019 Alcohol use disorder is one of the most prevalent mental health disorders worldwide, treatment options are limited, and relapse rates are high. There remains an urgent need for effective treatments. Research involving the therapeutic potential of classic
Gruppo, Katherine
core +1 more source
Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.Abstract Objectives Psychedelic‐assisted therapy (PAT) frequently utilises a “cotherapy” model, in which two therapists jointly support participants throughout dosing and psychotherapy sessions. While common in clinical trials, participant experiences of cotherapy remain underexplored.
Rachel Ham +3 more
wiley +1 more source
Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley +1 more source
, 2023 Psychedelic research became throttled in the 1970s, though the clinical interest for psychedelics has seen a resurgence in the last couple of decades for their application as psychotherapy-adjunct substances used to treat various psychological disorders.
Johansson, Andreas
core +3 more sources
Education for Healthcare Providers: Psilocybin-Assisted Psychotherapy [PDF]
Psilocybin-assisted psychotherapy is emerging as a promising therapeutic modality for addressing psychological distress in psychiatric and palliative care settings.
Carlson, Chelsi
core +1 more source
Depression is a mental disorder that severely affects one's ability to function in life. Though traditional psychological, pharmacological, and somatic treatments are available - patients often experience adverse side effects and do not achieve remission,
Bodin, Amanda, Berger, Kristina
core +3 more sources
Structural basis for psilocybin biosynthesis
Nature CommunicationsPsilocybin shows significant therapeutic potential for psilocybin-assisted psychotherapy in addressing various psychiatric conditions. The biosynthetic approach promises rapid and efficient production of psilocybin.
Chunyan Meng +12 more
doaj +1 more source
Long‐Term Therapy Experiences in Post‐suicidal Men: Safety, Gender and Iatrogenic Harm
MultiPsych, Volume 1, Issue 3, September 2026.Men who have survived a suicide attempt and engaged in long‐term psychotherapy describe the therapeutic relationship as the primary agent of recovery—not technique, but sustained relational presence. Gender dynamics, developmental history and institutional failure all shape engagement. These findings challenge short‐term service models and carry direct
Alastair Coomes, Joel Vos, Ron Roberts
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le +8 more
wiley +1 more source