Cérebros, máquinas e psiquiatria [psiquiatria computacional]
Debates em Psiquiatria, 2012 A ideia de que os processos mentais são computacionais e, portanto, reprodutíveis artificialmente trouxe um grande impulso para a criação da Inteligência Artificial e se tornou um marco teórico que revitalizou a psicologia cognitiva, o conexionismo, a ...
Fernando Portela Camara
doaj +2 more sources
Visual rating of the medial temporal lobe atrophy on magnetic resonance imaging in elderly patients with type I bipolar disorder [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Bipolar disorder (BD) is associated with cognitive impairments and structural brain changes, including brain atrophy. This study aims to evaluate medial temporal lobe atrophy (MTA) – through the visual evaluation of hippocampus, choroid fissure, and temporal horn – in elderly individuals with type‐I bipolar BD on magnetic resonance ...
Rodolfo Braga Ladeira +5 more
wiley +2 more sources
Dose‐Dependent Effects of Lithium on Biological Pathways, Ribosomes, Mitochondria, and Proteasomes in Hippocampal Neurons: Insights from Gene and Protein Expression [PDF]
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Lithium salts have a well‐established role in the treatment of psychiatric disorders, such as major affective disorders, and more recently Alzheimer disease. Experimental and clinical studies have provided evidence that lithium may exert neuroprotective effects at therapeutic and subtherapeutic doses.
Orestes Vicente Forlenza +2 more
wiley +2 more sources
Phosphatidylcholine as a potential AD‐related biomarker in Down syndrome, but not in Alzheimer's disease patients: Preliminary findings [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Individuals with Down Syndrome (DS) exhibit dementia‐related aging associated with the development of Alzheimer's Disease (AD). This relationship occurs because the amyloid precursor protein (APP), which plays a crucial role in AD pathogenesis, is located on chromosome 21—the same chromosome affected by trisomy in DS.
Bruna Berribilli Bortoleto +4 more
wiley +2 more sources
A transcriptomic approach to characterize human monocyte‐derived microglia‐like cells as a potential tool for identifying biological markers of mild cognitive impairment [PDF]
Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.Abstract Background Microglial cells are critical in Alzheimer’s disease (AD) pathophysiology. Most human studies have analyzed microglia from postmortem brain samples or microglia derived from induced‐pluripotent stem cells. Our study provides evidence to support human monocyte‐derived microglia‐like cells as a cellular model to identify potential ...
Marcela Valdés‐Tovar +11 more
wiley +2 more sources
Heart rate variability during sleep stages in older adults with mild cognitive impairment [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Several dementias are associated to cardiovascular disease risk factors. Mild cognitive impairment (MCI) can lead to dementia. One of the less known possible cardiovascular risk factor comprises a lower index of arousals per hour during Rapid Eye Movement (REM) sleep.
Alejandra Rosales‐Lagarde +4 more
wiley +2 more sources
Post‐COVID‐19 cognitive decline: Preliminary findings from a Brazilian cohort study [PDF]
Alzheimer's &Dementia, Volume 21, Issue S3, December 2025.Abstract Background Many people who have been affected by COVID‐19 report impaired cognitive abilities resulting in functional impairments and worsening quality of life. The present study aims to investigate the occurrence of cognitive impairments in a cohort of survivors of moderate or severe forms of COVID‐19.
Glenda Dias dos Santos +2 more
wiley +2 more sources
Inflammatory modulation and cellular stress response to lithium treatment in the hippocampus of Alzheimer's disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Alzheimer's Disease (AD) involves chronic neuroinflammation, exacerbated by the activation of Toll‐like receptors (TLRs), such as TLR4, which amplify neurodegeneration through inflammatory cascades. This study evaluated the impact of chronic lithium treatment on the modulation of these inflammatory pathways in transgenic mice (3xTg ...
Carlos Wagner Leal Cordeiro Júnior +4 more
wiley +2 more sources
Publicações ABP documentos e vídeos = ABP Publications documents and videos, 2017 Segundo a Organização Mundial da Saúde (OMS) a definição de saúde está ligada não apenas à ausência de doença, mas a um estado completo de bem-estar físico, mental e social. Ainda de acordo com a OMS, a prevenção e tratamento de certas doenças mentais, como esquizofrenia e depressão, por exemplo, contribui diretamente para a redução de índices como o ...
Leonardo Baldaçara +1 more
openalex +2 more sources
Resting‐State EEG in Mild Cognitive Impairment considering Fractal Dimensions and AI classifiers: a pilot study [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Mild Cognitive Impairment (MCI) is a neuropsychiatric syndrome with an alarming annual increase in Mexico. The Encuesta Nacional sobre Salud y Envejecimiento en México (ENASEM, Spanish for the National Survey of Health and Aging in Mexico) reports an estimated global incidence rate of 31.4 cases per 1,000 person‐years in subjects ...
Brenda Fernanda Noguez‐Ruiz +4 more
wiley +2 more sources