Results 21 to 30 of about 17,785 (168)

Competition (‘Steal’ Phenomenon) between [⁶⁸Ga]Ga-PSMA-11 Uptake in Prostate Tumor Tissue Versus Healthy Tissue

Pharmaceutics, 2021
We aimed to clarify whether a steal ‘phenomenon’ exists by investigating if uptake of ‘prostate specific membrane antigen’ (PSMA) in prostate tumor tissue correlates with the uptake in healthy tissue. Patients with prostate cancer referred for a [68Ga]Ga-
Esmée C. A. van der Sar, Bart de Keizer, Marnix G. E. H. Lam, Arthur J. A. T. Braat   +3 more
doaj   +1 more source

Comparison of PSMA-TO-1 and PSMA-617 labeled with gallium-68, lutetium-177 and actinium-225

EJNMMI Research, 2022
Background PSMA-TO-1 (“Tumor-Optimized-1”) is a novel PSMA ligand with longer circulation time than PSMA-617. We compared the biodistribution in subcutaneous tumor-bearing mice of PSMA-TO-1, PSMA-617 and PSMA-11 when labeled with 68Ga and 177Lu, and the ...
Catherine Meyer, Vikas Prasad, Andreea Stuparu, Peter Kletting, Gerhard Glatting, Jonathan Miksch, Christoph Solbach, Katharina Lueckerath, Lea Nyiranshuti, Shaojun Zhu, Johannes Czernin, Ambros J. Beer, Roger Slavik, Jeremie Calais, Magnus Dahlbom   +14 more
doaj   +1 more source

PSMA expression in hepatic colorectal cancer metastasis [PDF]

Journal of Pathology and Translational Medicine
Background Prostate-specific membrane antigen (PSMA) is expressed in the neovasculature of various malignancies, such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC).
Eundong Park, Michel Kmeid, Xin Wang, Haiyan Qiu, Clifton G. Fulmer, Marcello P. Toscano, Nusret Bekir Subasi, Maciej Gracz, Hwajeong Lee   +8 more
doaj   +1 more source

Lutetium-177-PSMA-617: A Vision of the Future

Cancer Biology & Therapy, 2022
In the last decade, many life-prolonging therapeutic options have emerged for metastatic castration-resistant prostate cancer (mCRPC). The recent VISION trial is the first to demonstrate a survival benefit of Lutetium-177[177Lu]Lu-PSMA-617 in post ...
Elias Chandran, William D. Figg, Ravi Madan   +2 more
doaj   +1 more source

Design, Synthesis, Computational, and Preclinical Evaluation of ^natTi/⁴⁵Ti-Labeled Urea-Based Glutamate PSMA Ligand

Molecules, 2020
Despite promising anti-cancer properties in vitro, all titanium-based pharmaceuticals have failed in vivo. Likewise, no target-specific positron emission tomography (PET) tracer based on the radionuclide 45Ti has been developed, notwithstanding its ...
Kristina Søborg Pedersen, Christina Baun, Karin Michaelsen Nielsen, Helge Thisgaard, Andreas Ingemann Jensen, Fedor Zhuravlev   +5 more
doaj   +1 more source

Comparative analysis of PSMA, PSA3, and TMPRSS2-ERG as diagnostic and prognostic biomarkers in prostate cancer patients

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Prostate cancer is one of the most common male malignancies and a significant global health concern. Existing prostate cancer diagnosis methods, like digital rectal exams, biopsy, and imaging, are often limited in term-s of invasiveness, cost,
Thikra Majid Muhammed, Aliaa Hashim Farag, Zina Lafta Hassan, Osama A. Mohsein   +3 more
doaj   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Precision Medicine in Prostate Cancer: The Role of Molecular Diagnostics and Targeted Therapies

Annals of Urologic Oncology
Prostate cancer is a major health problem in the world, and it has been complicated by the fact that the illness is quite heterogeneous. In the past, the use of PSA testing and histopathological grading has been constrained by failure to reliably ...
Amira Guedouar, Enas Roumieh
doaj   +1 more source

A Fast and Simple Method for the Determination of TBA in ¹⁸F-Labeled Radiopharmaceuticals

Pharmaceuticals, 2020
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes.
Nils Erik Halvorsen, Ole Heine Kvernenes   +1 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source