Results 41 to 50 of about 17,785 (168)

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

In Silico Investigation of the Interactions of Piflufolastat F-18 and Flotufolastat F-18 Radiopharmaceuticals with Biological Targets Relevant to Prostate Cancer Diagnosis

Revue des Sciences de la Santé
Le cancer de la prostate constitue l’un des principaux problèmes de santé publique chez l’homme à l’échelle mondiale. Le diagnostic précoce et précis demeure un défi majeur, en particulier pour la détection des lésions de faible volume et des récidives ...
Roland M. MBIKAYI, Ignis M. KITUKU, Rosaire KITOKO, Bofilis A. KOMOY, Didi D. BIBELAYI, Joséphine N. KANKOLONGO, Kenny S. KALE, Damien S.T. TSHIBANGU, Raphael M. MULONGO, KOTO-TE-NYIWA NGBOLUA, Virima MUDOGO, Aristote MATONDO   +11 more
doaj   +1 more source

Towards a Precision Medicine Approach and In Situ Vaccination against Prostate Cancer by PSMA-Retargeted oHSV

Viruses, 2021
Prostate specific membrane antigen (PSMA) is a specific high frequency cell surface marker of prostate cancers. Theranostic approaches targeting PSMA show no major adverse effects and rule out off-tumor toxicity.
Andrea Vannini, Federico Parenti, Daniela Bressanin, Catia Barboni, Anna Zaghini, Gabriella Campadelli-Fiume, Tatiana Gianni   +6 more
doaj   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

First-in-human evaluation of four novel PSMA-targeted PET radiotracers with non-canonical amino acid linkage: A comparative study

Pharmacological Research
PSMA-targeted radiopharmaceuticals have substantially advanced the management of prostate cancer; however, high nonspecific uptake in organs such as salivary glands and kidneys remains a clinical challenge.
Dong Dai, Xin Gao, Siqi Zhang, Hongyi Huang, Kun Wang, Jianjing Liu, Xingkai Wang, Yuan Miao, Zongxiao Liu, Panfeng Li, Qingshuang Lu, Shuo Jiang, Xueyao Chen, Licheng Yang, Yiliang Li, Rui Wang, Yingzi Zhang, Kuan Hu   +17 more
doaj   +1 more source

Development of an Albumin-Based PSMA Probe With Prolonged Half-Life

Frontiers in Molecular Biosciences, 2020
Prostate-specific membrane antigen (PSMA) is an attractive target for the diagnosis and therapy of prostate cancer as it is specifically overexpressed in prostate cancer cells.
Teli Liu, Chen Liu, Yanan Ren, Yanan Ren, Xiaoyi Guo, Jinquan Jiang, Qing Xie, Lei Xia, Feng Wang, Hua Zhu, Zhi Yang   +10 more
doaj   +1 more source

Nanoparticles in microdroplets: Recent advances in microfluidic generators for producing functional microbeads

Droplet, EarlyView.
Functional hybrid microbeads with electrical, magnetic, and/or optical responsiveness have emerged as versatile platforms for biotechnology. This review highlights recent advances in microfluidic technologies for producing such microbeads, with a focus on incorporating functional nanoparticles in microdroplet systems.
  Bayinqiaoge, Chengchen Zhang, Shi‐Yang Tang   +2 more
wiley   +1 more source

Combination of 99mTc-Labeled PSMA-SPECT/CT and Diffusion-Weighted MRI in the Prediction of Early Response After Carbon Ion Therapy in Prostate Cancer: A Non-Randomized Prospective Pilot Study

Cancer Management and Research, 2021
Ping Li,1– 3,* Chang Liu,4– 6,* Shuang Wu,2,3,7 Lin Deng,2,3,8 Guangyuan Zhang,2,3,8 Xin Cai,1– 3 Silong Hu,4– 6 Jingyi Cheng,2,3,6,9 Xiaoping Xu,4– 6 Bin Wu,2,3,10 Xiaomao Guo,2,3,7 Yingjian Zhang,4– 6 Shen Fu,5,11 ...
Li P, Liu C, Wu S, Deng L, Zhang G, Cai X, Hu S, Cheng J, Xu X, Wu B, Guo X, Zhang Y, Fu S, Zhang Q   +13 more
doaj  

Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry. [PDF]

PLoS ONE, 2017
Prostate specific membrane antigen (PSMA) targeted microbubbles (MBs) were developed using bioorthogonal chemistry. Streptavidin-labeled MBs were treated with a biotinylated tetrazine (MBTz) and targeted to PSMA expressing cells using trans-cyclooctene ...
Aimen Zlitni, Melissa Yin, Nancy Janzen, Samit Chatterjee, Ala Lisok, Kathleen L Gabrielson, Sridhar Nimmagadda, Martin G Pomper, F Stuart Foster, John F Valliant   +9 more
doaj   +1 more source

Machine Learning–Enhanced Fluorescence Cryptography with NADH‐Responsive Polymer Dots

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study presents a smart anticounterfeiting system using semiconducting polymer dots (Pdots) that exhibit tunable fluorescence responses to NADH. By integrating these dynamic optical signals with machine learning–based decoding, the work establishes a secure and intelligent encryption platform, showing a novel strategy that links chemical sensing ...
Zhengkun Zhan, Mingyue Gong, Zirui Zeng, Hangyu Liu, Xiaoliang Li, Zhuxin Dong, Xiaoju Men, Haobin Chen   +7 more
wiley   +1 more source