Results 81 to 90 of about 18,448 (248)

Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites

Molecules, 2019
Psoralen (P) and isopsoralen (IP) are the main active ingredients in the dried fruit of Psoralen corylifolia L. (PC), with a wide range of pharmacology activities.
Lu Liu, Lei Zhang, Ze-Xu Cui, Xiao-Yan Liu, Wei Xu, Xiu-Wei Yang   +5 more
doaj   +1 more source

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Scientific Reports, 2017
Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-
Peter R. Martin, S. Couvé, Caroline Zutterling, Mustafa S. Albelazi, R. Groisman, B. Matkarimov, J. Parsons, R. Elder, M. Saparbaev   +8 more
semanticscholar   +1 more source

The CYP71AZ P450 Subfamily: A Driving Factor for the Diversification of Coumarin Biosynthesis in Apiaceous Plants

Frontiers in Plant Science, 2018
The production of coumarins and furanocoumarins (FCs) in higher plants is widely considered a model illustration of the adaptation of plants to their environment.
Célia Krieger, Sandro Roselli, Sandra Kellner-Thielmann, Gianni Galati, Bernd Schneider, Jérémy Grosjean, Alexandre Olry, David Ritchie, Ulrich Matern, Frédéric Bourgaud, Alain Hehn   +10 more
doaj   +1 more source

Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells.

Molecular Medicine Reports, 2016
The resistance of cancer to chemotherapeutic agents is a major obstacle during chemotherapy. Clinical multidrug resistance (MDR) is commonly mediated by membrane drug efflux pumps, including ATP‑binding cassette subfamily B member 1, also termed P ...
Jingrui Jiang, Xiaohong Wang, K. Cheng, W. Zhao, Yitong Hua, Chengfeng Xu, Zhenlin Yang   +6 more
semanticscholar   +1 more source

Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway

BioMed Research International, 2017
Osteoporosis is a common disease causing fracture in older populations. Abnormal apoptosis of osteoblasts contributes to the genesis of osteoporosis. Inhibiting apoptosis of osteoblasts provides a promising strategy to prevent osteoporosis.
Shuqing Chen, Yongqian Wang, Yubin Yang, Ting Xiang, Jiahui Liu, Houming Zhou, Xinlin Wu   +6 more
semanticscholar   +1 more source

Profound Thrombocytopenia and Dyspnea 11 Days After Cardiac Surgery

American Journal of Hematology, Volume 100, Issue 7, Page 1234-1239, July 2025.
Sebastian Vuong, Menaka Pai, Sarah Patterson, Theodore E. Warkentin   +3 more
wiley   +1 more source

Anti-tumor effect and hepatotoxicity mechanisms of psoralen

Frontiers in Pharmacology
In recent years, natural products have gradually become an important source for new drug development due to their advantages of multi-components, multi-targets, and good safety profiles.
Dandan Meng, Yanling Dong, Qingxin Shang, Ziyuan Sun   +3 more
doaj   +1 more source

Psoralen-ultraviolet a treatment with Psoralen-ultraviolet B therapy in the treatment of psoriasis

Pakistan Journal of Medical Sciences, 2013
To compare the conventional psoralen-ultraviolet A treatment with psoralen-ultraviolet B therapy in the treatment of psoriasis.We studied 50 patients of plaque type psoriasis who were selected to receive either conventional psoralen-ultraviolet A or psoralen-ultraviolet B treatment.There was no significant difference between the two treatment groups in
Safia H Ahmed, Us-Sehar N, Ahmed Asim S
openaire   +3 more sources

Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-κB-mitogen-activated protein kinase signaling.

Experimental and Therapeutic Medicine, 2017
Osteoporosis is a systemic skeletal disease that leads to increased bone fragility and susceptibility to fracture. Approximately 50% of postmenopausal women develop osteoporosis as a result of postmenopausal estrogen deficiency.
Feimeng Li, Qihuo Li, Xiaoqing Huang, Yunting Wang, Chana Ge, Y. Qi, W. Guo, Hongtao Sun   +7 more
semanticscholar   +1 more source

Chemical Constituents and Antidiabetic Activity of Dichloromethane Extract from Ficus carica Leaves

Diabetes, Metabolic Syndrome and Obesity, 2023
Limei Lin, Yin Zhang Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, People’s Republic of ChinaCorrespondence: Yin Zhang, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical ...
Lin L, Zhang Y
doaj