Results 81 to 90 of about 19,791 (256)

Viral uncoating is directional: exit of the genomic RNA in a common cold virus starts with the poly-(A) tail at the 3′-end [PDF]

open access: yes, 2016
Upon infection, many RNA viruses reorganize their capsid for release of the genome into the host cell cytosol for replication. Often, this process is triggered by receptor binding and/or by the acidic environment in endosomes.
Blaas, Dieter   +6 more
core   +1 more source

Clinical patterns of vitiligo in Japan: A descriptive study using the JMDC claims database

open access: yesThe Journal of Dermatology, Volume 52, Issue 5, Page 831-840, May 2025.
Abstract Vitiligo is a chronic autoimmune disorder that profoundly impacts patients' quality of life. Real‐world data on vitiligo in Japan are limited. This descriptive, cross‐sectional study used a claims database to evaluate vitiligo prevalence, patient demographics, treatments, and comorbidities in Japanese patients with vitiligo.
Atsushi Tanemura   +5 more
wiley   +1 more source

Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins

open access: yesMolecules, 2014
A series of new analogs of combretastatin A-4 (CA-4, 1) with the A or B-ring replaced by a 3-oxo-2,3-dihydrofurocoumarin or a furocoumarin residue have been designed and synthesized by employing a cross-coupling approach. All the compounds were evaluated
Alla V. Lipeeva   +4 more
doaj   +1 more source

Chromatin structure and methylation of rat rRNA genes studied by formaldehyde fixation and psoralen cross-linking [PDF]

open access: yes, 2017
By using formaldehyde cross-linking of histones to DNA and gel retardation assays we show that formaldehyde fixation, similar to previously established psoralen photocross-linking, discriminates between nucleosome-packed (inactive) and nucleosome-free ...
Koller, Theodor   +3 more
core  

Safety and effectiveness of secukinumab in Japanese patients with generalized pustular psoriasis: A post‐marketing surveillance

open access: yesThe Journal of Dermatology, Volume 52, Issue 5, Page 773-786, May 2025.
Abstract Secukinumab is one of the human monoclonal antibodies recommended in the Japanese guidelines for patients with psoriasis, but few case reports and clinical studies on secukinumab for pustular psoriasis are available because of the rarity of the disease.
Ayako Fujishige, Noriko Seko
wiley   +1 more source

A study of comparison of PUVASOL and NBUVB in patients with vitiligo

open access: yesPigment International, 2018
Introduction: Vitiligo is an acquired, hypomelanotic disease, characterized by circumscribed depigmented macules. Phototherapy, which is the use of ultraviolet irradiation with or without exogenous photosensitizer is a well established treatment option ...
Vaaruni Ravishankar   +4 more
doaj   +1 more source

Early and Late Side Effects Associated with Photo(chemo)therapy [PDF]

open access: yes, 2010
Phototherapy (PUVA ve UVB) is a widely used and effective treatment method for a variety of dermatological diseases. Adverse effects associated with phototherapy can be classified as acute and chronic side effects.
Günseli Öztürk
core   +1 more source

Efficacy and Safety of Long‐Term Azathioprine Therapy for Severe Alopecia Areata: A 10‐Year Cohort Study

open access: yesJournal of Cosmetic Dermatology, Volume 24, Issue 5, May 2025.
ABSTRACT Background Alopecia areata is an autoimmune disease in which T cells may play a key role in its pathogenesis. Various immunosuppressive drugs have been employed with varying degrees of success. Objectives This study aimed to evaluate the long‐term efficacy and safety of azathioprine as a systemic monotherapy for moderate to severe alopecia ...
Susan Farshi, Parvin Mansouri
wiley   +1 more source

Ultrastructural Modification of the Plasma Membrane in HUT 102 Lymphoblasts by Long-Wave Ultraviolet Light, Psoralen, and PUVA [PDF]

open access: yes, 1990
Ultrastructural alterations of the plasma membrane in HUT 102 lymphoblasts were assessed after a 2-h interaction with a suprapharmacologic (15 μ/m1) concentration of 8-MOP, 2-h irradiation with UVA (2.1 mW/cm2), and the exposure of the HUT 102 cells to ...
Hornicek, Francis J   +3 more
core   +1 more source

The Impact of Regularly Used Treatments on Daily Life of Cutaneous T‐Cell and B‐Cell Lymphoma Patients

open access: yes
JEADV Clinical Practice, Volume 4, Issue 2, Page 552-555, June 2025.
Michelle Raaijmakers   +5 more
wiley   +1 more source

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