Results 51 to 60 of about 14,394 (262)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

On the age of PSR B 1509-58 [PDF]

Astronomy & Astrophysics, 2001
It is generally accepted that the PSR B1509-58 is associated with the supernova remnant (SNR) MSH 15-52 (G 320.4-01.2). The spin-down age of the pulsar is \simeq 1700 years, while the size and the general appearance of the SNR suggest that this system is much older. A few possible explanations of this discrepancy have been put forward.
openaire   +2 more sources

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Vaccinovigilance in Europe: need for timeliness, standardization and resources

Bulletin of the World Health Organization, 2004
OBJECTIVE: To identify gaps in the systems for reporting adverse events following immunization (AEFI) in Europe by means of an interactive database constructed using a standardized approach. METHODS: A comparative survey was conducted in 1999-2000, using
Kari S. Lankinen, Satu Pastila, Terhi Kilpi, Hanna Nohynek, P. Helena Mäkelä, Patrick Olin   +5 more
doaj  

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Evaluation of disaster safe education unit programme implementation in Mt. Merapi using the pressure state response approach

Jàmbá
Disaster Safe Education Unit (SPAB), also known globally as Comprehensive Safe School (CSS), aims to improve school residents’ resilience. Three pillars of SPAB have been established, but their implementation, to date, has not shown satisfactory results.
Puspita I. Wardhani, Muhammad Musiyam, Yunus A. Wibowo, Aries Dwi W. Rahmadana, Sri Utami, Edwin Maulana   +5 more
doaj   +1 more source

X-ray observations of PSR J0218+4232 and of PSR B1937+21 [PDF]

International Astronomical Union Colloquium, 1996
Navarro et al. (1995) have discovered a 2.3 ms radio pulsar in a 2.0 day orbit around a low-mass companion. An interesting feature of this pulsar, PSR J0218+4232, is that radio emission is discovered throughout the pulse period; this is taken by Navarro et al. as an indication that the pulsar magnetic field is almost aligned with the rotation axis, and
Frank Verbunt, Helen M. Johnston, A.G. de Bruyn, Michiel van der Klis   +3 more
openaire   +1 more source

Facilitators’ champion behaviors for delivering an evidence‐based parenting program

American Journal of Community Psychology, EarlyView.
Abstract Effective implementation of parenting programs relies on multiple factors, particularly the role of facilitators who actively deliver and support the intervention. Facilitators’ champion behaviors or the efforts they make to encourage implementation, can positively impact the outcomes of these programs.
Camila Regina Lotto, Elisa Rachel Pisani Altafim, Dana Charles McCoy, Maria Beatriz Martins Linhares   +3 more
wiley   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Assessment of PSR as a Novel Parameter in Perfusion Imaging for CNS Tumor Characterization: An Observational Study

National Board of Examinations Journal of Medical Sciences
Introduction: Magnetic resonance imaging (MRI) has emerged as the primary modality for diagnosing and evaluating central nervous system (CNS) tumors, transitioning from structural to functional assessment.
Niva B, Jeevithan Shanmugam, Shriram Varadharajan, Seetharaman Cannane, Umaiban KV   +4 more
doaj   +1 more source