Results 201 to 210 of about 513,891 (263)

Bright Light Therapy in Psychiatric Disorders: Mechanisms, Clinical Procedures and Evidence. [PDF]

Life (Basel)
Pardossi S, Bossini L, Milani V, Rescalli MB, Cuomo A.   +4 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Epigenomic alterations in psychiatric disorders and glioblastoma. [PDF]

Epigenomics
Šmon J, Jovčevska I, Paska AV, Kouter K.   +3 more
europepmc   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Low-Intensity Focused Ultrasound Neuromodulation in Psychiatric Disorders: Mechanisms, Models, and Missing Links. [PDF]

Biol Psychiatry
Arulpragasam AR, Theyel B, Barredo J, Pouille F, Gillotti JG, Greenberg BD, Wout-Frank MV', Philip NS.   +7 more
europepmc   +1 more source

Copy number variants reveal divergent genetic and diagnostic cortical signatures across psychiatric disorders

Kumar K, Liao Z, Kopal J, Moreau C, Ching C, Modenato C, Snyder W, Kazem S, Martin C, Belanger A, Fontaine V, Jizi K, Huguet G, Boen R, Kushan L, Silva A, Bree Mvd, Linden D, Owen M, Hall J, Lippé S, Dumas G, Draganski B, Almasy L, Thomopoulos S, Jahanshad N, Sønderby I, Andreassen O, Glahn D, Raznahan A, Bearden C, Paus T, Thompson P, Jacquemont S.   +33 more
europepmc   +1 more source

Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders. [PDF]

Psychol Med
Chang WC, Hung DP, Chen MH, Su TP, Bai YM, Chen YY, Tu PC.   +6 more
europepmc   +1 more source

Epigenetic and Transcriptomic Pathways Underlying Animal Models of Cognitive and Psychiatric Disorders: A Scoping Review. [PDF]

Curr Issues Mol Biol
Rathored J, Pal A, Sai Painkra D.
europepmc   +1 more source