Results 91 to 100 of about 130,154 (269)

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Latent classes of nonresponders, rapid responders, and gradual responders in depressed outpatients receiving antidepressant medication and psychotherapy [PDF]

, 2015
BackgroundWe used growth mixture modeling (GMM) to identify subsets of patients with qualitatively distinct symptom trajectories resulting from treatment. Existing studies have focused on 12-week antidepressant trials.
Bagby, Michael, De Bolle, Marleen, De Fruyt, Filip, Quilty, Lena, Rouillon, Frederic, Thibodeau, Michel   +5 more
core   +2 more sources

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Determinants of mental and physical health-related quality of life among patients hospitalized for suicidal behavior [PDF]

, 2017
The current study was interested in exploring the clinical factors related to mental and physical health-related quality of life among patients hospitalized for suicidal behavior.
Daray, Federico Manuel, Grendas, Leandro Nicolás, Lado, Gisela, Portela, Alicia, Puppo, Soledad, Rodante, Demián, Rojas, Sasha, Vidjen, Patricia   +7 more
core   +1 more source

Aging and the Spectral Properties of Brain Hemodynamics

Advanced Science, EarlyView.
As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park, Abraham Z. Snyder, Manu S. Goyal, Timothy O. Laumann, John J. Lee, Babatunde Adeyemo, Nicholas Metcalf, Andrei G. Vlassenko, Joshua S. Shimony, Eric C. Leuthardt   +9 more
wiley   +1 more source

Estrutura fatorial do questionário de morbidade psiquiátrica de adultos aplicado em amostras populacionais de cidades brasileiras

Revista de Saúde Pública
A análise de componentes principais é uma técnica de estatística multivariada utilizada para examinar a interdependência entre variáveis. A sua principal característica é a capacidade de reduzir dados, e tem sido usada para o desenvolvimento de ...
Sérgio Baxter Andreoli, Jair de Jesus Mari, Sérgio Luis Blay, Naomar de Almeida-Filho, Evandro Coutinho, Josimar França, Jefferson Gomes Fernandes, Ellis D'Arrigo Busnello   +7 more
doaj  

Predictors of violent incidents amongst patients in psychiatric intensive care units: A review of global evidence [PDF]

, 2020
Aim: The objective is to identify key predictors of violent behaviour amongst patients admitted to PICUs. Methods: A literature search was carried out in five online databases using a predefined strategy with terms relevant to the setting and ...
Gumber, Anil, Gumber, Leher, Gumber, Sneh   +2 more
core  

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Psychiatric morbidities in human immunodeficiency virus (HIV) positive patients

Open Journal of Psychiatry and Allied Sciences, 2019
Background: The HIV/AIDS epidemic has existed for over two decades in India. The mental health needs of people infected with HIV has to be evaluated and looked after properly by mental health professionals.
Adya Shanker Srivastava, Raj Kumar, Madhukar Rai, Maheshwar Nath Tripathi, Jai Singh Yadav, Achyut Kumar Pandey   +5 more
doaj   +1 more source