Results 101 to 110 of about 4,725,283 (256)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Validation and examination of the longitudinal factor structure of the Japanese mood disorder questionnaire among perinatal women: An online cohort study

Journal of Affective Disorders Reports
The Mood Disorder Questionnaire (MDQ) is widely used to screen for bipolar disorder (BD), yet its psychometric properties remain underexplored in perinatal populations.
Chika Kubota, Chika Yokoyama, Haruna Irino, Yasue Mitamura, Aiko Okatsu, Satoko Sasagawa, Ayako Kanie, Aiichiro Nakajima, Miyuki Makino, Sayaka Aoyama, Yaeko Kataoka, Masaru Horikoshi, Hironori Kuga, Masaya Ito   +13 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Validity and test–retest reliability of the Swedish version of the Geriatric Depression Scale among very old adults

BMC Geriatrics
Background The Geriatric Depression Scale (GDS) has shown good validity and reliability, but few studies have examined the GDS among very old adults or the Swedish translation.
Sandra Snellman, Carl Hörnsten, Birgitta Olofsson, Yngve Gustafson, Hugo Lövheim, Johan Niklasson   +5 more
doaj   +1 more source

Depression, anxiety, stress and adverse childhood experience among first-year university students

Journal of Family Medicine and Primary Care
Objective: The purpose of this research was to examine the levels of Depression, Anxiety, Stress (DAS) and adverse childhood experiences (ACEs) in first-year university students in Saudi Arabia.
Samah Khalid Alharthi, Sulhi Ali Alfakeh, Jumana Turki Aljohani   +2 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Health needs assessment: development of a simplified risk probability scale design for rapid mental health screening in emergency frontline rescue teams

Frontiers in Public Health
BackgroundEmergency frontline rescue workers during the COVID-19 pandemic faced elevated psychological risks, yet existing tools lack specificity for crisis contexts.AimTo develop a simplified risk probability scale (SRPS) tailored for rapid self ...
Yifei Chen, Yan Bo, Zhuanzhuan Han, Guowei Fan   +3 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The assessment of anxiety levels in patients with posttraumatic stress disorder

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: The purpose of this study was to measure state and trait anxiety levels of veterans who developed posttraumatic stress disorder following combat or landmine injuries, or vehicle accidents.\nMethods: The anxiety levels of 98 veterans (mean age
Ebru Sinici, Cemil Yildiz, Servet Tunay, Huseyin Ozkan, Mehmet Altinmakas   +4 more
doaj  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source