Results 101 to 110 of about 61,008 (268)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Not missing at random : Missing data are associated with clinical status and trajectories in an electronic monitoring longitudinal study of bipolar disorder

There is limited information on the association between participants' clinical status or trajectories and missing data in electronic monitoring studies of bipolar disorder (BD).
Mulsant, Benoit H, Halabi, Ramzi, Patterson, Rachel,, Hintze, Arend, O'Donovan, Claire, Ortiz, Abigail, Halabi, Ramzi,, DeShaw, Alexandra,, Ortiz, Abigail,, DeShaw, Alexandra, O'Donovan, Claire,, Alda, Martin, Mulsant, Benoit H,, Husain, Muhammad I, Hintze, Arend,, Husain, Muhammad I,, Patterson, Rachel, Alda, Martin,   +17 more
core   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Developing a model of occupational therapy practice for children with attention deficit hyperactivity disorder (ADHD)

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 15/06/2005.This three-stage study led to the development of a delineation model of occupational therapy practice for children with Attention Deficit ...
Chu, Sidney Kin Hoi
core  

Functional milestones and clinician ratings of everyday functioning in people with schizophrenia: overlap between milestones and specificity of ratings

, 2012
Everyday functioning is known to be impaired in people with schizophrenia, across multiple functional domains. It is not clear, however, how impairments across social, vocational, and residential domains overlap with each other, Further, although there ...
Patterson, Thomas L, Prestia, Davide, Twamley, Elizabeth W, Sabbag, Samir, Durand, Dante, Harvey, Philip D   +5 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Depression, anxiety, stress and adverse childhood experience among first-year university students

Journal of Family Medicine and Primary Care
Objective: The purpose of this research was to examine the levels of Depression, Anxiety, Stress (DAS) and adverse childhood experiences (ACEs) in first-year university students in Saudi Arabia.
Samah Khalid Alharthi, Sulhi Ali Alfakeh, Jumana Turki Aljohani   +2 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Factor structure of the Brief Psychiatric Rating Scale in unipolar depression

, 2010
Background: In clinical practice patients with unipolar depression present with a variety of symptom clusters that may combine together in many different ways.
Angelo Picardi, Luciana Marmai, Bruno Biancosino, Massimo Biondi, Luigi Grassi   +4 more
core   +2 more sources

Validity and test–retest reliability of the Swedish version of the Geriatric Depression Scale among very old adults

BMC Geriatrics
Background The Geriatric Depression Scale (GDS) has shown good validity and reliability, but few studies have examined the GDS among very old adults or the Swedish translation.
Sandra Snellman, Carl Hörnsten, Birgitta Olofsson, Yngve Gustafson, Hugo Lövheim, Johan Niklasson   +5 more
doaj   +1 more source