Results 101 to 110 of about 130,154 (269)

Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents a fully automated miniature mass spectrometry system for high‐throughput therapeutic drug monitoring. Integrating magnetic solid‐phase extraction, self‐aspiration sampling miniature mass spectrometer, and U‐net deep learning quantitative algorithm, it achieves rapid (8 samples/30 min), precise (R2 > 0.99, RSD < 10%), and portable ...
Yuanhao Zhou, Jiawen Ai, Zi Ye, Kexin Chen, JingXiong Lin, Zhenhua Zhang, Mi Luo, Benjie Zhou, Shijian Xiang, Jianhua Zhou, Xinming Huo   +10 more
wiley   +1 more source

Health needs assessment: development of a simplified risk probability scale design for rapid mental health screening in emergency frontline rescue teams

Frontiers in Public Health
BackgroundEmergency frontline rescue workers during the COVID-19 pandemic faced elevated psychological risks, yet existing tools lack specificity for crisis contexts.AimTo develop a simplified risk probability scale (SRPS) tailored for rapid self ...
Yifei Chen, Yan Bo, Zhuanzhuan Han, Guowei Fan   +3 more
doaj   +1 more source

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

The Self-Perception and Relationships Tool (S-PRT): A novel approach to the measurement of subjective health-related quality of life

Health and Quality of Life Outcomes, 2004
Background The Self-Perception and Relationships Tool (S-PRT) is intended to be a clinically responsive and holistic assessment of patients' experience of illness and subjective Health Related Quality of Life (HRQL).
Wishart Paul M, Atkinson Mark J, Wasil Bushra I, Robinson John W   +3 more
doaj   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light‐Driven Nanozyme Sensor Array and Machine Learning

Advanced Science, EarlyView.
A novel photoresponsive nanozyme sensor array, combining metal‐organic frameworks (MOFs) with advanced machine learning algorithms, provides a breakthrough in rapid neurotransmitter detection and disease diagnostics. This sensor array is capable of accurately identifying neurotransmitter profiles associated with neurological disorders, offering ...
Kun Yu, Siyuan Lu, Kaiwen Qiu, Yuanzun Zhang, Aobing Sun, Shiqi Gong, Kai Wang, Xuzhu Gao, Xiangyu Xu, Hao Wang   +9 more
wiley   +1 more source

Validity and test–retest reliability of the Swedish version of the Geriatric Depression Scale among very old adults

BMC Geriatrics
Background The Geriatric Depression Scale (GDS) has shown good validity and reliability, but few studies have examined the GDS among very old adults or the Swedish translation.
Sandra Snellman, Carl Hörnsten, Birgitta Olofsson, Yngve Gustafson, Hugo Lövheim, Johan Niklasson   +5 more
doaj   +1 more source

Initial Validation of a Brief Pictorial Measure of Caregiver Aggression: The Family Aggression Screening Tool [PDF]

, 2016
In the present study, we report on the development and initial psychometric properties of the Family Aggression Screening Tool (FAST). The FAST is a brief, self-report tool that makes use of pictorial representations to assess experiences of caregiver ...
Barker, ED, Cecil, CAM, Holden, GW, McCrory, EJ, Viding, E   +4 more
core  

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source