Results 121 to 130 of about 912,895 (292)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Mental health promotion in disasters: exploring the synergy of artificial intelligence, spirituality, and psychology: a SWOT analysis

Discover Psychology
Background Natural and man-made disasters affect people's lives yearly and may lead to suffering, poverty, and psychological challenges. In this context, artificial intelligence (AI) plays an important role in the diagnosis and treatment of psychological
Rasoul Fattahipour, Simintaj Sharififar, Fatemeh Teymouri, Maryam Azizi, Milad Ahmadi Marzaleh   +4 more
doaj   +1 more source

Integrating mental health into primary care for displaced populations: the experience of Mindanao, Philippines [PDF]

, 2011
Mueller, Y, Cristofani, S, Rodriguez, C, Malaguiok, R, Gil, T, Grais, R, Souza, R   +6 more
core   +2 more sources

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Menghidupkan Kembali Senyum dan Asa: Sinergi Play Therapy dan Psychological First Aid bagi Korban Banjir Demak

Madaniya
Banjir besar yang melanda Kabupaten Demak, Jawa Tengah, menyebabkan kerusakan signifikan dan memaksa banyak warga mengungsi, termasuk di Terminal Jati di Kabupaten Kudus.
Ruth Natalia Susanti, Trubus Raharjo, Iranita Hervi Mahardayani, Mohammad Khasan, Ahmad Faqihuddin   +4 more
doaj   +1 more source

Minority Student Perceptions of Professional Pscyhology Application Packets: A Qualitative Study [PDF]

, 1995
This article reports the results of a qualitative study designed to determine issues salient in Black and Hispanic American students\u27 review and evaluation of program-application packets in professional psychology.
Burkard, Alan W., Cancelli, Anthony A., Mendez, Giovanni, Ponterotto, Joseph G., Sussman, Lynn, Wasilewski, Lynn, Yoshida, Roland   +6 more
core   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Empowering Nurses and Midwives with Psychological First Aid Skills: A Crucial Step in Supporting Mothers After Stillbirth [PDF]

Women’s Health Bulletin
Zahra Saboohi
doaj   +1 more source