Results 131 to 140 of about 4,653,289 (297)

Brief Digital Interventions to Support the Psychological Well-being of NHS Staff During the COVID-19 Pandemic: 3-Arm Pilot Randomized Controlled Trial (Preprint)

, 2021
Johannes H. De Kock, Helen Ann Latham, Richard G. Cowden, Breda Cullen, Katia Narzisi, Shaun Jerdan, Sarah‐Anne Muñoz, Stephen J Leslie, Andreas Stamatis, J. I. Eze   +9 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Can Perceivers Differentiate Intense Facial Expressions? Eye Movement Patterns

Behavioral Sciences
Recent research on intense real-life faces has shown that although there was an objective difference in facial activities between intense winning faces and losing faces, viewers failed to differentiate the valence of such expressions.
Leyu Huang, Tongtong Zhu, Jiaotao Cai, Yan Sun, Yanmei Wang   +4 more
doaj   +1 more source

Positive Psychological Micro-Interventions to Improve the Work–Family Interface: Use Your Resources and Count Your Blessings [PDF]

, 2020
Maria C. W. Peeters, Elianne F. van Steenbergen, Jan Fekke Ybema   +2 more
openalex   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Cognitive functions following initiation of antipsychotic medication in adolescents and adults at clinical high risk for psychosis: a naturalistic sub group analysis using the MATRICS consensus cognitive battery

Child and Adolescent Psychiatry and Mental Health
Background The effects of antipsychotic (AP) medications on cognitive functions in individuals at clinical high-risk (CHR) of psychosis are poorly understood. This study compared the effects of AP treatment on cognitive improvement in CHR adolescents and
TianHong Zhang, YanYan Wei, XiaoChen Tang, HuiRu Cui, LiHua Xu, YeGang Hu, YingYing Tang, Qiang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, ChunBo Li, JiJun Wang   +12 more
doaj   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Can community and educational interventions designed from the ground-up promote social and emotional learning? Experimental and quasi-experimental impacts of a country-wide Portuguese initiative

Frontiers in Education
IntroductionSocial and emotional learning (SEL) is a powerful predictor of several outcomes throughout life, such as relationships, citizenship behavior, academic and job performance, and mental and physical health.
M. Clara Barata, Joana Alexandre, Catarina Castro, Carla Colaço   +3 more
doaj   +1 more source

Psychological interventions following terrorist attacks [PDF]

, 2008
Irwin J. Mansdorf
openalex   +1 more source