Results 111 to 120 of about 19,645 (222)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Mental health changes after 4 months of weight loss treatment with the glucagon‐like peptide‐1 analogue liraglutide 3.0 mg

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Objective This observational study examined changes in mental health and wellbeing after 4‐months liraglutide 3.0 mg treatment in patients with obesity and explored associations with weight loss. Methods We included 98 patients with obesity treated with liraglutide 3.0 mg.
Susanne Kuckuck, Nina van Gerwen, Johanneke E. Oosterman, Mesut Savas, Maryam Kavousi, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F.C. van Rossum   +7 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Fetishism Due to Methamphetamine (Glass) Abuse: A Case Report [PDF]

Background: Fetishism is a type of paraphilia. The focus of sexual arousal in fetishism is oriented towards inanimate objects. Sexual arousal and craving are some of the reasons the youth resort to crystal (glass).
Ali Mehdizadeh Zare Anari MD1, Alireza Ghafarinezhad MD2,,, Hoda Soltani MSc3,   +1 more
core  

Alcohol Induced Psychotic Disorder: a comparitive study in patients with alcohol dependance, schizophrenia and normal controls [PDF]

, 2007
Thesis(DMed (Psychiatry))-- University of Stellenbosch, 2007.Alcohol-induced psychotic disorder (also known as alcohol hallucinosis) is a complication of alcohol abuse that requires clinical differentiation from alcohol withdrawal delirium and ...
Emsley, R. A., Jordaan, Gerhard
core  

Vaporized cannabis versus placebo for acute migraine: A randomized, double‐blind, placebo‐controlled crossover trial

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the efficacy of cannabis for the treatment of acute migraine. Background Preclinical and retrospective studies suggest cannabinoids may be effective in migraine treatment. However, there have been no randomized clinical trials examining the efficacy of cannabinoids for acute migraine.
Nathaniel M. Schuster, Mark S. Wallace, Thomas D. Marcotte, Dawn C. Buse, Euyhyun Lee, Lin Liu, Michelle Sexton   +6 more
wiley   +1 more source

IRIS Guidelines: Early Intervention in Psychosis IRIS Guidelines Update September 2012 [PDF]

, 2012
Revision of the original 1998 IRIS ...
Baird, J., Bell, S., Brabban, A., Burbach, F., Campbell, A., Dodgson, G., Eranti, S., Fox, T., Fraser, R., French, P., Hember, M., Jeavons, J., Kumar, D., Laughton-Brown, H., Leeks, A., McGowan, S., Pearson, D., Shiers, D., Smith, Jo, Williams, M.S., Zoetti, M.   +20 more
core   +1 more source

Evaluating the Safety, Feasibility and Acceptability of Weighted Blankets in Acute Care for People With Dementia: A Randomised Control Trial

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To evaluate the safety, feasibility and acceptability of weighted blankets for patients with dementia who experience agitation in acute care. Design Randomised controlled trial. Methods Patients with dementia experiencing agitation at a single hospital were recruited between May 2023 and January 2024. Participants were randomly assigned to
A. Fox, E. Tomkins, M. Valcovich, E. Ballard   +3 more
wiley   +1 more source

Differences Between Early-Phase Primary Psychotic Disorders With Concurrent Substance Use and Substance-Induced Psychoses—Correction [PDF]

Archives of General Psychiatry, 2005
openaire   +1 more source

Evaluating a Group‐Based Intervention Addressing Fear of Childbirth in Multiparous Pregnant Women: A Mixed Methods Feasibility Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To assess the feasibility and acceptability of a group‐based intervention for addressing fear of childbirth in multiparous women. Design Single‐arm non‐randomised feasibility trial with a convergent mixed methods design. Methods The intervention, conducted at a central maternity hospital and led by a psychiatric nurse and a midwife ...
Laura Sandström, Marja Kaunonen, Heini Huhtala, Anna Liisa Aho   +3 more
wiley   +1 more source