Results 21 to 30 of about 191,827 (269)

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

BMC Evolutionary Biology, 2018
Background One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution.
Niladri Banerjee, Tatiana Polushina, Francesco Bettella, Sudheer Giddaluru, Vidar M. Steen, Ole A. Andreassen, Stephanie Le Hellard   +6 more
doaj   +1 more source

Transition to Psychosis in Individuals at Clinical High Risk: Meta-analysis

European Psychiatry, 2023
Introduction Estimating the current likelihood of transitioning from a clinical high risk for psychosis (CHR-P) to psychosis holds paramount importance for preventive care and applied research.
G. Salazar De Pablo, J. Radua, I. Bonoldi, V. Arienty, F. Besana, A. Cabras, A. Catalan, P. Fusar-Poli   +7 more
doaj   +1 more source

Are informants required to obtain valid ratings on the Positive and Negative Syndrome Scale (PANSS)?

Schizophrenia, 2023
Ratings on the Positive and Negative Syndrome Scale (PANSS) are ideally based on both a patient interview and an informant questionnaire. In research and clinical settings, however, the informant questionnaire is often omitted.
Cecilie Marie Nielsen, Pernille Kølbæk, David Dines, Mark Opler, Christoph U. Correll, Søren Dinesen Østergaard   +5 more
doaj   +1 more source

Delving into the world of webCHAT – an e-mental health support service for distressed youths in Singapore

Digital Health
Background Young people face high rates of mental health issues, yet many do not seek professional help. In 2017, CHAT launched webCHAT – a free, anonymous, one-on-one synchronous web-based text service managed by case managers (CMs) to support young ...
Yi Ping Lee, Ying Ying Lee, Hamidah Binte Otheman, Charmaine Tang, Mythily Subramaniam, Swapna K Verma   +5 more
doaj   +1 more source

Successful switching from risperidone to cariprazine in a schizophrenic patient with pronounced functional deficit. Case report

Frontiers in Psychiatry, 2023
A 22-year-old male was admitted to an in-patient psychiatric unit for treatment, after a period of 2 years of increasing psychotic symptoms corresponding to a very severe case of schizophrenia across the entire scale of symptom disorder domains along ...
Johan Sahlsten Schölin, José Rodriguez Cruz, Stephan Hjorth   +2 more
doaj   +1 more source

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Co‐producing an inclusive‐care model for young people transitioning from adolescent eating disorder services to adult care: A qualitative study protocol for Transition for Eating Disorder Youth intervention

European Eating Disorders Review, EarlyView., 2023
Abstract Eating disorders (EDs) present a chronic issue to child paediatric mental health services due to their high mortality and relapse rates. The transition from Child and Adolescent Mental Health Services to Adult Mental Health Services is a particularly high‐risk period for young people with EDs given their high vulnerability to change, which can
Maria Livanou, Anya Heneghan, Elli Bouliou, Grace Hill, Katharine Mills, Sophie Naylor Roll, Zara Smalley, Jun Teh, Janet Treasure   +8 more
wiley   +1 more source

Machine learning for brain age prediction: Introduction to methods and clinical applications

EBioMedicine, 2021
The rise of machine learning has unlocked new ways of analysing structural neuroimaging data, including brain age prediction. In this state-of-the-art review, we provide an introduction to the methods and potential clinical applications of brain age ...
Lea Baecker, Rafael Garcia-Dias, Sandra Vieira, Cristina Scarpazza, Andrea Mechelli   +4 more
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source