Results 21 to 30 of about 195,409 (316)
Translational Psychiatry, 2021 Alterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear.
Robert A. McCutcheon +4 more
doaj +1 more source
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
BMC Evolutionary Biology, 2018 Background One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution.
Niladri Banerjee +6 more
doaj +1 more source
Transition to Psychosis in Individuals at Clinical High Risk: Meta-analysis
European Psychiatry, 2023 Introduction Estimating the current likelihood of transitioning from a clinical high risk for psychosis (CHR-P) to psychosis holds paramount importance for preventive care and applied research.
G. Salazar De Pablo +7 more
doaj +1 more source
Are informants required to obtain valid ratings on the Positive and Negative Syndrome Scale (PANSS)?
Schizophrenia, 2023 Ratings on the Positive and Negative Syndrome Scale (PANSS) are ideally based on both a patient interview and an informant questionnaire. In research and clinical settings, however, the informant questionnaire is often omitted.
Cecilie Marie Nielsen +5 more
doaj +1 more source
Frontiers in Psychiatry, 2023 A 22-year-old male was admitted to an in-patient psychiatric unit for treatment, after a period of 2 years of increasing psychotic symptoms corresponding to a very severe case of schizophrenia across the entire scale of symptom disorder domains along ...
Johan Sahlsten Schölin +2 more
doaj +1 more source
Machine learning for brain age prediction: Introduction to methods and clinical applications
EBioMedicine, 2021 The rise of machine learning has unlocked new ways of analysing structural neuroimaging data, including brain age prediction. In this state-of-the-art review, we provide an introduction to the methods and potential clinical applications of brain age ...
Lea Baecker +4 more
doaj +1 more source
Digital HealthBackground Young people face high rates of mental health issues, yet many do not seek professional help. In 2017, CHAT launched webCHAT – a free, anonymous, one-on-one synchronous web-based text service managed by case managers (CMs) to support young ...
Yi Ping Lee +5 more
doaj +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong +7 more
wiley +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source