Results 71 to 80 of about 241,274 (304)

The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle, Silvia Iñiguez‐Barrio, Maria Aurora Arrue, Leire Erkoreka   +3 more
wiley   +1 more source

Multimodal functional imaging investigation before and after the onset of psychosis [PDF]

, 2008
Mr A. was a 20-yr-old white male with no medical history of note. His GP, who was concerned about his poor psychosocial functioning, referred him to a specialist service offering advice and support for young people at risk for ...
Grasby, Paul, Broome, Matthew, Oliver Howes, Isabel Valli, McGuire, Philip, Broome, Matthew; id_orcid, Fusar-Poli, Paolo; id_orcid, Allen, Paul, Howes, Oliver (Oliver D.), Fusar-Poli, Paolo, Valli, Isabel, Broome, Matthew R., Paul Grasby, Matthew Broome, Philip McGuire, Howes, Oliver, Paolo Fusar-Poli, Paul Allen   +17 more
core   +2 more sources

Pattern classification of brain activation during emotional processing in subclinical depression: psychosis proneness as potential confounding factor [PDF]

PeerJ, 2013
We used Support Vector Machine (SVM) to perform multivariate pattern classification based on brain activation during emotional processing in healthy participants with subclinical depressive symptoms.
Gemma Modinos, Andrea Mechelli, William Pettersson-Yeo, Paul Allen, Philip McGuire, Andre Aleman   +5 more
doaj   +2 more sources

Influence of Molecular Genetic Classes on Behavior in Prader‐Willi Syndrome

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A wide range of behavioral phenotypes has been described in PWS patients including autism spectrum disorder (ASD). The prevalence of behavioral disorders was studied in 292 participants over 3 years with genetically confirmed PWS (N = 164 females and N = 128 males) with deletion (N = 182) and mUPD (maternal uniparental disomy) (N = 99).
Ranim Mahmoud, Merlin G. Butler, Wai Park, Jennifer L. Miller, Daniel J. Driscoll, June‐Anne Gold, Virginia Kimonis   +6 more
wiley   +1 more source

Extending the ATP9A‐Related Phenotypic Spectrum: Indication of Schizophrenia Susceptibility

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT ATP9A, which belongs to the P4‐ATPase family of proteins, is involved in the efficient transport of vesicles from the Golgi apparatus to the plasma membrane, as well as the release of extracellular vesicles from human cells. In 2021, a loss‐of‐function variant of this gene was identified as being associated with a recessive neurodevelopmental ...
Camille Verebi, Céline Louveau, Bertrand Diebold, Natacha Gaitch, Arnaud Hubas, Martine Gautier Vallee, Jérôme Champ, Anais L'Haridon, Sophie Georgin Lavialle, Boris Chaumette, Thierry Bienvenu   +10 more
wiley   +1 more source

Stressful life events and their association with symptom severity and functioning in first-episode psychosis

Schizophrenia
Stressful life events (SLEs) are a risk factor for psychosis; however, evidence on the impact of SLEs in individuals with first-episode psychosis (FEP) is limited.
Stefania Tognin, Mariia Moroz, Aljawharah Almuqrin, Maria Chiara Del Piccolo, Ryan Hammoud, Anna Georgiades, Andrea Mechelli   +6 more
doaj   +1 more source

Biological Predictors of Clozapine Response: A Systematic Review

Frontiers in Psychiatry, 2018
Background: Clozapine is the recommended antipsychotic for treatment-resistant schizophrenia (TRS) but there is significant variability between patients in the degree to which clozapine will improve symptoms.
Ruta Samanaite, Amy Gillespie, Amy Gillespie, Kyra-Verena Sendt, Grant McQueen, James H. MacCabe, Alice Egerton   +6 more
doaj   +1 more source

Maternal Factors Modifying the Link Between Genetic Risk for Autism and Developmental Milestones

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Although common genetic liability—quantified through polygenic risk scores (PRS)—accounts for substantial variance in autism spectrum disorder (ASD) liability, how prenatal environmental exposures interact with genetic predisposition to shape developmental outcomes remains poorly understood. Using the data from Autism Genetic Resource Exchange
Liliana D'Alesio, Vishani Nimish Patel, McKenna Walsh, Erick Messias, Ping‐I Lin   +4 more
wiley   +1 more source

Using smartphone-based assessment of social experience to predict relapse in first-episode psychosis

Schizophrenia
Social-affective changes are early indicators of psychosis relapse, yet their dynamic and subjective nature makes them difficult to capture between routine clinical assessments.
Ryan Hammoud, Anna Georgiades, Maria Chiara Del Piccolo, Shangqing Liu, Aljawharah Almuqrin, Robert Stewart, Ioannis Bakolis, Natasha Vorontsova, Stefania Tognin, Andrea Mechelli   +9 more
doaj   +1 more source

Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity

International Journal of Bipolar Disorders, 2017
Background Individuals with bipolar disorder present with moderate impairments in social cognition during the euthymic state. The impairment extends to theory of mind and to the perception of emotion in faces and voices, but it is unclear if emotion ...
Anja Vaskinn, Trine Vik Lagerberg, Thomas D. Bjella, Carmen Simonsen, Ole A. Andreassen, Torill Ueland, Kjetil Sundet   +6 more
doaj   +1 more source