Results 81 to 90 of about 153,974 (268)

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

AIM review tool: artificial intelligence for smarter systematic review screening

npj Artificial Intelligence
In this study, we present the AIM Review Tool, a modern web-based application that integrates active and supervised machine learning to accelerate the screening of publications for systematic reviews.
Sergio Mena, Esther Rituerto-González, Fiona Coutts, Jana von Trott, Grace R. Jacobs, Linda Bryant, Louise Moles, Nicoleta Sirbu, Liisi Promet, Dominic Oliver, Muhammad S. Ahmed, Paolo Fusar-Poli, Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn, Nikolaos Koutsouleris, Paris Alexandros Lalousis   +15 more
doaj   +1 more source

Preterm birth and structural brain alterations in early adulthood

NeuroImage: Clinical, 2014
Alterations in cortical development and impaired neurodevelopmental outcomes have been described following very preterm (VPT) birth in childhood and adolescence, but only a few studies to date have investigated grey matter (GM) and white matter (WM ...
Chiara Nosarti, Kie Woo Nam, Muriel Walshe, Robin M. Murray, Marion Cuddy, Larry Rifkin, Matthew P.G. Allin   +6 more
doaj   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Feasibility and Preliminary Efficacy of a Guided Self‐Help Digital Intervention for Adults With Food Insecurity, Recurrent Binge Eating, and Type 2 Diabetes Mellitus: A Pilot Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Food insecurity is increasingly linked to binge eating and weight‐related health issues like type 2 diabetes mellitus, but no eating disorder interventions have been tested among individuals with food insecurity. We conducted a single‐arm pilot test of FoodSteps‐FI, a guided self‐help digital intervention for binge eating adapted for
Andrea K. Graham, Rebecca L. Flynn, Isabel R. Rooper, Chidiebere Azubuike, Lindsay D. Lipman, Adrian Ortega, Leah M. Parsons, Graham C. Miller, Damien Lekkas, Jennifer E. Wildes   +9 more
wiley   +1 more source

Physical Health and Transition to Psychosis in People at Clinical High Risk

Biomedicines
Background: The clinical high risk for psychosis (CHR-P) construct represents an opportunity for prevention and early intervention in young adults, but the relationship between risk for psychosis and physical health in these patients remains unclear ...
Andrea De Micheli, Umberto Provenzani, Kamil Krakowski, Dominic Oliver, Stefano Damiani, Natascia Brondino, Philip McGuire, Paolo Fusar-Poli   +7 more
doaj   +1 more source

Daily Body (Dis‐)Satisfaction and Dietary Restriction in Women Across the Eating Disorder Spectrum

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Body dissatisfaction is a key risk factor in eating disorder development: It is theorized to promote dietary restriction, thereby contributing to symptom onset. Evidence for this pathway primarily comes from cross‐sectional or multi‐wave questionnaire studies in bulimia nervosa (BN) and anorexia nervosa (AN).
Michaela R. Buehler, Ann‐Kathrin Arend, Julia Reichenberger, Jens Blechert   +3 more
wiley   +1 more source

Safe and Sound: Is Safeness a Specific Affective Dimension Related to Eating Disorder Behaviors?

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Safeness is a warm, soothing emotional state that is often experienced in the presence of close others. Safeness is thought to be distinct from other positive emotions or the absence of negative emotions and is shown to predict mental health variables over and above other emotions.
Ege Bicaker, Alexia E. Miller, Vittoria Trolio, Sarah E. Racine   +3 more
wiley   +1 more source

Epidemiology of Intensive Nutritional Interventions and Restraints in Hospitalizations for Anorexia Nervosa: Annual National Trends of the United States

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Despite the clinical relevance of enteral and parenteral tube feeding and restraint use in anorexia nervosa (AN), national‐level data on their use have remained limited, particularly for total parenteral nutrition (TPN) and percutaneous endoscopic gastrostomy (PEG).
Hiroyasu Ino, Nancy S. Jecker, Yoshiyuki Takimoto, Eisuke Nakazawa   +3 more
wiley   +1 more source