Results 131 to 140 of about 9,321 (238)

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source

Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.
Han Kyu Na, Yeeun Sun, Chan Wook Park, Jung Hyun Lee, Yun Young Choi, Quynh Phuong Vo, Seok Jong Chung, Han Soo Yoo, Chul Hyoung Lyoo, Young H. Sohn, Jin Yong Hong, Phil Hyu Lee   +11 more
wiley   +1 more source

Digital Assessment of Metacognition Across the Psychosis Continuum: Measures, Validity, and Clinical Integration-A Scoping Review. [PDF]

Medicina (Kaunas)
Martiadis V, Raffone F, Clemente S, Massa A, De Berardis D.   +4 more
europepmc   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhury, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, EarlyView.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Relationships between attachment insecurity, beliefs about the self and others, paranoia, and social functioning across the psychosis continuum. [PDF]

Br J Clin Psychol
de-la-Higuera-Gonzalez P, Allefeld C, de-la-Torre-Luque A, Guillén AI, Díaz-Marsá M, Fett AK.   +5 more
europepmc   +1 more source

Mental disorders in adults with malnutrition: Prevalence and association with nutritional outcomes: A retrospective cohort study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Despite often coexisting, the association between mental disorders and malnutrition is not well characterized. This study aimed to describe the prevalence of mental disorders and their association with malnutrition, nutritional interventions, and clinical outcomes.
Vivian V. Nguyen, Paramat Thimichai, Jennifer Jin, Leanna Tsang, Patricia To, Leah Gramlich   +5 more
wiley   +1 more source

Rehabilitation needs of long COVID patients in British Columbia

PM&R, EarlyView.
Abstract Introduction COVID‐19 can result in persistent symptoms and functional impairment that significantly impact daily functioning, highlighting the need for targeted rehabilitation. However, there is a lack of data on what proportion of long COVID patients need rehabilitation and which types are required.
Débora M. Petry Moecke, Evan H. Kwong, Sonya Cressman, Jennifer Yao, Chiara Singh, Carolyn Taylor, Pat G. Camp   +6 more
wiley   +1 more source

Characterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach. [PDF]

Psychol Med
Scott I, Aarts E, Wannan C, Gao CX, Clark S, Hartmann S, Nguyen J, Cavve B, Hartmann JA, Dwyer D, van der Tuin S, Raposo de Almeida E, Lin A, Amminger GP, Thompson A, Wood SJ, Yung AR, van den Berg D, McGorry PD, Wigman JTW, Nelson B.   +20 more
europepmc   +1 more source

Planting for healthy air: Urban biodiversity enhances natural chemical environments

PLANTS, PEOPLE, PLANET, EarlyView.
Cities urgently need nature to improve public health, support biodiversity, and increase resilience to climate change. Yet not all green spaces offer the same benefits. In this study, we show that more diverse urban plantings create richer “chemical environments”; subtle, naturally scented atmospheres formed by plant emissions that can influence how ...
Aurora Ruggeri, Fethi Ben Fraj, Gaetan Glauser, Gregory Röder, Ola Söderström, Sergio Rasmann   +5 more
wiley   +1 more source