Results 111 to 120 of about 24,901 (225)

The Polysubstance Assessment Tool: Reliability, acceptability and feasibility of a novel measure of polysubstance use

open access: yesAddiction, Volume 121, Issue 6, Page 1410-1420, June 2026.
Abstract Background and aims There are currently no brief quantitative assessments that capture the drug patterns of people who engage in use of more than one drug on the same day or simultaneously. The current study examined the retest reliability, acceptability and feasibility of a new quantitative assessment to measure polysubstance use.
Amanda M. Bunting   +7 more
wiley   +1 more source

The neurobiology of psychostimulant addiction [PDF]

open access: yes, 2006
Introducción y desarrollo. Las drogas psicoestimulantes incluyen anfetamínicos, alcaloides naturales como la cocaína y metilxantinas. Inducen una fuerte dependencia, que se manifiesta por fenómenos de base neurobiológica como la sensibilización y la ...
Fernández-Espejo, Emilio
core  

SEMASEARCH Study Design: Real‐World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4602-4609, June 2026.
ABSTRACT Background Although semaglutide 2.4 mg has demonstrated significant weight loss efficacy in clinical trials, real‐world data, particularly with regard to clinically complex and underrepresented populations, remain limited. Objectives The study aims to assess the real‐world effectiveness and patient‐reported outcomes associated with the use of ...
Pierre Bel Lassen   +20 more
wiley   +1 more source

Psychostimulant Drugs and Neuroplasticity

open access: yesPharmaceuticals, 2011
Drugs of abuse induce plastic changes in the brain that seem to underlie addictive phenomena. These plastic changes can be structural (morphological) or synaptic (biochemical), and most of them take place in the mesolimbic and mesostriatal circuits ...
Emilio Fernandez-Espejo   +1 more
doaj   +1 more source

Genetic Architecture of Addiction‐Relevant Behaviors in Outbred Sprague–Dawley Rats Reveals Loci for Anxiety‐Like and Nociceptive Traits

open access: yesGenes, Brain and Behavior, Volume 25, Issue 3, June 2026.
Genome‐wide association analyses in outbred Sprague–Dawleys identified loci for anxiety‐like and nociceptive behavior on chromosomes 1, 14, and 17, which are distinct from facets of exploratory locomotion significant in our GWAS of a F2 intercross of selectively bred high‐ and low‐responder (to a novel environment) Sprague–Dawleys.
Apurva S. Chitre   +11 more
wiley   +1 more source

Brain and Cognition for Addiction Medicine: From Prevention to Recovery Neural Substrates for Treatment of Psychostimulant-Induced Cognitive Deficits

open access: yesFrontiers in Psychiatry, 2019
Addiction to psychostimulants like cocaine, methamphetamine, and nicotine poses a continuing medical and social challenge both in the United States and all over the world. Despite a desire to quit drug use, return to drug use after a period of abstinence
Manoranjan S. D’Souza
doaj   +1 more source

Rationale for psychostimulants in ADHD [PDF]

open access: yesBMJ, 2005
EDITOR—Confusion about levels of diagnosis causes most debate about psychostimulants in childhood behavioural disorders.1 DSM-IV definitions are all syndromes—that is, symptoms and signs unrelated to pathology and aetiology. Most effective therapies treat pathology and aetiology; syndromes can be treated only symptomatically.
openaire   +2 more sources

Multimodal MRI Reveals Brain Structural Differences and Executive Dysfunction in Early Methamphetamine Abstinence

open access: yesBrain and Behavior, Volume 16, Issue 5, May 2026.
In a sample of 13 early‐abstinent methamphetamine users (≤30 days) and 14 controls, multimodal MRI revealed lower cortical volume in frontal and lingual regions and thickness of the lateral occipital and lingual cortex. These structural changes accompanied poorer executive performance, suggesting dose‐related grey‐matter vulnerability in visual ...
Ben Bristow   +13 more
wiley   +1 more source

Stable interindividual differences in modafinil’s effect on vigilance during sleep deprivation

open access: yesFrontiers in Pharmacology
RationaleIn specific operational contexts (i.e., military aviation), the off-label use of modafinil is officially regulated. However, safety concerns are still raised.ObjectivesTo study the stability and robustness of interindividual differences in ...
Jeroen Van Cutsem   +24 more
doaj   +1 more source

Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms

open access: yesMolecules, 2019
Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors
Claudia Calpe-López   +2 more
doaj   +1 more source

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