Results 121 to 130 of about 50,737 (331)

Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia

open access: yesPharmacological Research, 2023
The paucity of medications with novel mechanisms for pain treatment combined with the severe adverse effects of opioid analgesics has led to an imperative pursuit of non-opioid analgesia and a better understanding of pain mechanisms.
Guangchao Zhang   +18 more
doaj  

Self‐stigma among people with epilepsy: Comparison between Germany and Japan

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Epilepsy is a neurological disorder characterized by recurrent seizures, with prevalence and treatment availability varying across countries. Stigma associated with epilepsy significantly impacts the quality of life (QOL) of people with epilepsy (PWE).
Izumi Kuramochi   +8 more
wiley   +1 more source

Most common principal diagnoses assigned to Australian emergency department presentations involving alcohol use: a multi‐centre study

open access: yesAustralian and New Zealand Journal of Public Health, Volume 46, Issue 6, Page 903-909, December 2022., 2022
Abstract Objectives: Alcohol is the most widely consumed psychoactive substance in Australia and the consequences of alcohol consumption have enormous personal and social impacts. This study aimed to describe the principal diagnoses of emergency department (ED) presentations involving alcohol use in the previous 12 hours at eight hospitals in Victoria ...
Peter Miller   +24 more
wiley   +1 more source

Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models

open access: yesPharmacological Research
Aberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a ...
Xiu Yang   +7 more
doaj  

Anxious Dads and Depressed Moms: Child Disability and the Mental Health of Parents

open access: yesHealth Economics, EarlyView.
ABSTRACT Having a child with a disability undoubtedly affects parents in many ways, including their well‐being. However, the specific mental health trajectories of parents, differentiated by the severity of impairments and parental roles, remain under‐explored. We investigate the mental‐health effects of having a child with a disability.
Derek Asuman   +2 more
wiley   +1 more source

Delirium‐associated medication in people at risk: A systematic update review, meta‐analyses, and GRADE‐profiles

open access: yesActa Psychiatrica Scandinavica, Volume 147, Issue 1, Page 16-42, January 2023., 2023
Abstract Background Drug‐associated delirium is a common but potentially preventable neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for delirium‐associated medication is uncertain due to a lack of high‐quality studies.
Michael Reisinger   +4 more
wiley   +1 more source

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