Results 101 to 110 of about 1,330,663 (304)

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

iScience
Summary: Experimental studies have shown that neuropathic pain impairs hippocampal synaptic plasticity. Here, we sought to determine the underlying mechanisms responsible for synaptic changes in neuropathic painful mouse hippocampal neurons.
Li Yang, Qiaoqiao Liu, Yaxuan Zhao, Ninghua Lin, Yue Huang, Qihui Wang, Kehui Yang, Runa Wei, Xiaotong Li, Ming Zhang, Lingyun Hao, Hongjun Wang, Zhiqiang Pan   +12 more
doaj   +1 more source

Enhancing quality of mental health service for veterans with seizures

Epilepsia, EarlyView.
Abstract Psychiatric disorders are commonly identified in people with seizures (PWS). Comorbid mood, anxiety, and trauma‐ and stressor‐related disorders are highly prevalent and not consistently recognized or treated promptly. Veterans with seizures are particularly vulnerable to neuropsychiatric comorbidities, including a higher prevalence of ...
Maria Raquel Lopez, W. Curt LaFrance Jr., Kristen Mordecai, Anna E. Blanken, Mary Jo Pugh, Krista Ocier, Hamada Altalib   +6 more
wiley   +1 more source

Predicting levetiracetam neuropsychiatric adverse effects using graph‐theoretical electroencephalographic network metrics in drug‐naive focal epilepsy: A multicenter longitudinal study

Epilepsia, EarlyView.
Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical analysis has emerged as a valuable tool for identifying neurophysiological ...
Marco Sferruzzi, Lorenzo Ricci, Margherita Anna Grazia Matarrese, Francesca Izzi, Fabio Placidi, Biagio Maria Sancetta, Emanuele Cerulli Irelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Mario Tombini, Giovanni Assenza   +10 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated mitochondrial biogenesis

Acta Biochimica et Biophysica Sinica
Bone cancer pain (BCP), due to cancer bone metastasis and bone destruction, is a common symptom of tumors, including breast, prostate, and lung tumors. Patients often experience severe pain without effective treatment.
Yang Long, Li Miaomiao, Liu Yucheng, Bai Yang, Yin Tianyu, Chen Yangyang, Jiang Jinhong, Liu Su   +7 more
doaj   +1 more source

Knowledge and Perception Towards Psychotropic Drugs Among the General Population in Saudi Arabia. [PDF]

Psychol Res Behav Manag
Eatedal M Al-Shareef,1 Alaa M Kadah Salim,1 Nada M Al-Farrah,1 Bader M Al-Murad,1 Adnan A Moallem,1 Mohammed A Radwan,1 Salman Hakami,2 Asim M Alshanberi,1,3 Mohammed Shaikhomer,4 Safaa M Alsanosi5 1General Medicine Program, Batterjee Medical College ...
Al-Shareef EM, Kadah Salim AM, Al-Farrah NM, Al-Murad BM, Moallem AA, Radwan MA, Hakami S, Alshanberi AM, Shaikhomer M, Alsanosi SM.   +9 more
europepmc   +2 more sources

Assessment and management of dyspareunia in peri‐ and postmenopausal women: A phenotype‐based gynecologic approach

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Dyspareunia in peri‐ and postmenopausal women is common, clinically consequential, and often undertreated in gynecologic practice. Although genitourinary syndrome of menopause (GSM) is a frequent contributor, intercourse‐related pain may also reflect vestibular, pelvic floor, dermatologic, inflammatory, treatment‐related, and psychosocial ...
Marek Broul, Marcel Vančo, Jaroslava Banýrová, Aneta Hujová   +3 more
wiley   +1 more source

Outcomes of early first‐trimester medical abortion following bariatric surgery: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare medical termination of pregnancy (TOP) failure in patients with and without prior bariatric surgery (BS) and to compare outcomes by BS subtype. Methods We performed a retrospective cohort study of medical TOP at a single university teaching center between January 2019 and April 2024.
Shai Ingram, Adi Dayan‐Schwartz, Uri Kaplan, Gali Garmi, Noah Zafran   +4 more
wiley   +1 more source

Posttraumatic stress disorder 2 months after induced vaginal delivery: A multicenter prospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives An increased risk of postpartum posttraumatic stress disorder (PTSD) has been reported in women who had labor induced. Knowledge of childbirth‐related PTSD in this context remain poorly documented. Our aim was to assess the PTSD prevalence and identify characteristics associated with it after induced vaginal delivery at or near term.
Alizée Froeliger, Catherine Deneux‐Tharaux, Lola Loussert, Anne Laure Sutter‐Dallay, Hugo Madar, Loïc Sentilhes, on behalf of the Tranexamic Acid for Preventing Postpartum Hemorrhage Following a Vaginal Delivery (TRAAP) study group, Loïc Sentilhes, Norbert Winer, Elie Azria, Marie Victoire Sénat, Camille Le Ray, Delphine Vardon, Franck Perrotin, Raoul Desbrière, Florent Fuchs, Gilles Kayem, Guillaume Ducarme, Muriel Doret‐Dion, Cyril Huissoud, Caroline Bohec, Philippe Deruelle, Astrid Darsonval, Jean‐Marie Chrétien, Aurélien Seco, Valérie Daniel, Catherine Deneux‐Tharaux   +26 more
wiley   +1 more source

Efficacy of transcranial direct current stimulation for improving postoperative quality of recovery in elderly patients undergoing lower limb major arthroplasty: a randomized controlled substudy

Frontiers in Neurology
BackgroundPrevious studies have demonstrated improvements in motor, behavioral, and emotional areas following transcranial direct current stimulation (tDCS), but no published studies have reported the efficacy of tDCS on postoperative recovery quality in
Mingshu Tao, Mingshu Tao, Jie Yang, Jie Yang, Rongguang Liu, Rongguang Liu, Song Zhang, Yuan Han, Chunyan Li, Chunyan Li, Qi Wei, Qi Wei, Dexian Chen, Dexian Chen, Jiaxing Fang, Jiaxing Fang, Hongxing Zhang, Yuwei Wang, He Liu, He Liu, He Liu, He Liu, Jun-Li Cao, Jun-Li Cao   +23 more
doaj   +1 more source