Results 81 to 90 of about 42,511 (262)

Profile and use of licit psychotropic substances in the former Rabat-Sale-Zemmour-Zaër Region (Morocco): the case of tiflet city

The Pan African Medical Journal, 2018
INTRODUCTION: Psychopharmacology today faces serious challenges, especially related inappropriate drug choices, abuse and resulting side effects. The aim of this pharmacy based study in the City of Tiflet was to profile the prescription and usage ...
Khadija Karjouh, Fatima-Zahra Azzaoui, Ahmed Ahami, Samira Boulbaroud   +3 more
doaj   +1 more source

Determination of THC and THC‐COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study

Drug Testing and Analysis, EarlyView.
A new extraction method was developed and validated for the extraction of THC and THC‐COOH from capillary blood samples collected as dried blood spots. The extracts were analysed using HPLC–MS/MS resulting in high extraction efficiencies for both THC and THC‐COOH.
Matthias Bantle, Willi Schirmer, Joel Bruegger, Thomas Wüthrich, Andreas Längin, Lena Zwicker, Reto Auer, Wolfgang Weinmann   +7 more
wiley   +1 more source

Assessment of Potential Drug–Drug Interactions of Psycholeptics and Antidepressants in Outpatient Settings

Pharmacy
Mental health is an important segment in preserving overall health and represents a significant public health issue. In modern times, mental health disorders have risen, often requiring complex pharmacotherapy and chronic monitoring.
Iva Marović, Ivana Marinović, Vesna Bačić Vrca, Ivana Samardžić   +3 more
doaj   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

PSYCHOTROPIC DRUGS IN PREGNANCY

Psychiatry and Clinical Psychopharmacology, 2021
The teratogenic effects of commonly prescribed psychopharmacologic agents in animals and human fetus are summarized in this article. Since the human fetus is beyond the pharmacological investigations for ethical reasons, it is considered to importance ...
Erden Kilic, Gökhan BAYHAN
doaj  

Epilepsy in emerging adulthood: Clinical, psychosocial, and surgical challenges

Epilepsia, EarlyView.
Abstract Objective Emerging adulthood (EAs; ages 19–29 years) is a unique developmental stage marked by major psychological, social, and occupational transitions. We sought to characterize the clinical, psychosocial, and surgical features of epilepsy in emerging adulthood, considering both current age and age at epilepsy onset.
Graham A. McLeod, Colin B. Josephson, Samuel Wiebe, The Calgary Comprehensive Epilepsy Program Collaborators, Felippe Borlot, Guillermo Delgado‐García, Paolo Federico, Nathalie Jette, Karl Martin Klein, William Murphy, Neelan Pillay, Andrea Salmon, Shaily Singh, The Epilepsy Surgery Satisfaction Questionnaire Study Group, Mark J. Atkinson, Walter J. Hader, Mark R. Keezer, Oluwaseyi A. Lawal, Sophia Macrodimitris, Kristina Malmgren, Dang K. Nguyen, Scott B. Patten, Tolulope T. Sajobi, Ruby Sharma, Yves Starreveld, José Tellez‐Zenteno, Sandra Wahby   +26 more
wiley   +1 more source

Carrier-free nanomedicines: Mechanisms of formation and biomedical applications

Giant
In recent years, significant advancements in nanotechnology have yielded remarkable improvements in biomedical applications. Nanocarriers, harnessed from the principles of nanotechnology, have garnered widespread utilization in medicine delivery and ...
Xinrui Dong, Hu Liu, Haibao Liu, Xiaoqin Zhang, Xiaoran Deng   +4 more
doaj   +1 more source