Results 141 to 150 of about 164,611 (306)
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
Pten Dose Affects Prostate Tumor Progression
, 2013 Pten+/− mice develop hyperplasia, dysplasia, and low-grade PIN. Ptenhy/− mice develop at complete penetrance high-grade PIN at a young age (8–10 wk) and roughly 25% present invasive CaP around 8 mo.
Antonio Di Cristofano (2222) +11 more
core +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
Expression and functional analyses of PTEN during embryonic development in zebrafish, Danio rerio
, 2007 中文摘要 細胞增殖、分化及移動在胚發育過程中具有極其重要的意義，已知有許多蛋白質分子涉及調控這些細胞生理活動，而近來的研究更著重於細胞凋亡(apoptosis)、腫瘤發生(tumorigenesis)及癌症等方面之探討。磷酸肌醇磷酸酶PTEN/MMAC1為一種腫瘤抑制蛋白質，其藉由將磷脂醯肌醇三磷酸酯(phosphatidylinositol 3,4,5-trisphosphate)去磷酸化，進而抑制細胞之生存、增殖及移動，許多研究指出PTEN在調控哺乳類及昆蟲胚正常發育上扮演重要的角色 ...
張靜農, Chang, Ching-Ning
core
The role of PTEN in TRAIL sensitivity. A, effect of loss of PTEN in TRAIL-induced growth inhibition.
, 2013 Mouse prostate epithelial cells with wild type PTEN (PTEN+/+), PTEN knockout (PTEN+/−) and heterozygous (PTEN−/−) were plated in 96-well plates, and then treated with 100 ng/ml TRAIL for 48 h.
Jun-Ying Zhou (365505) +3 more
core +1 more source
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source
A catalase nanocapsule inhibits VSMCs proliferation and migration through PTEN/NLRP3 pathway
Frontiers in PharmacologyBackgroundAberrant VSMC proliferation, migration, and phenotypic switching drive vascular remodeling. Oxidative stress is pivotal, but effective antioxidants are limited.MethodsA catalase-loaded nanocapsule (CAT-nc) was developed for sustained ROS ...
Yudan Wang +8 more
doaj +1 more source
, 2015 (A) In reciprocal co-immunoprecipation experiments, the amounts of Rak and PTEN association were examined in ARV-infected or p17-transfected cells. Western blot assay of PTEN, and NEDD4-1 contained in PTEN or Rak immunoprecipates was carried out. The p17-
Kuo-Pin Chuang (780064) +5 more
core +1 more source
Advanced Science, EarlyView.A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao +34 more
wiley +1 more source