Results 151 to 160 of about 164,611 (306)

Initial characterization of PTEN.

, 2015
(A) Analysis of PTEN-L, wild-type PTEN, and K13A PTEN on a Coomassie R-250–stained polyacrylamide (12% w/v) gel containing sodium dodecylsulfate (0.1% w/v). (B) Representative progress curves for the turnover of PIP3 (10, 15, or 40 μM) by wild-type PTEN.
Sean B. Johnston (685153), Ronald T. Raines (369613)   +1 more
core   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

大鼠miR-664-1-5p靶向PTEN/Akt/Nrf2通路减轻缺氧/复氧PC12细胞氧化损伤的机制研究Mechanistic Study on Rat miR-664-1-5p Targeting the PTEN/Akt/Nrf2 Pathway to Attenuate Oxidative Damage in PC12 Cells Induced by Hypoxia/Reoxygenation

Zhongguo cuzhong zazhi
目的 探讨大鼠小分子核糖核酸（micro ribonucleic acid，miRNA）-664-1-5p（以下简称miR-664-1-5p）对缺氧/复氧后肾上腺嗜铬细胞瘤（adrenal pheochromocytoma，PC12）细胞损伤的影响及作用机制。 方法 体外培养PC12细胞，分为空白组、缺氧/复氧组、缺氧/复氧+阴性对照（negative control，NC）模拟物（mimic）组、缺氧/复氧+miR-664-1-5p mimic组。采用实时荧光定量PCR检测miR-664-1 ...
彭艳，冯文战，刘沁，唐红梅，刘祎，高立，汪思嘉，白雪PENG Yan, FENG Wenzhan, LIU Qin, TANG Hongmei, LIU Yi, GAO Li, WANG Sijia, BAI Xue
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

DNA methylation of selected tumor suppressor genes in endometrial hyperplasia

Biomedical Papers
Aims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods.
Ondrej Dvorak, Munachiso Ndukwe, Marcela Slavickova, Jan Laco, Jiri Spacek   +4 more
doaj   +1 more source

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

, 2015
Kun-Chun Chiang,1,4 Huang-Yang Chen,1 Shu-Yuan Hsu,2 Jong-Hwei S Pang,3 Shang-Yu Wang,4 Jun-Te Hsu,4 Ta-Sen Yeh,4 Li-Wei Chen,5 Sheng-Fong Kuo,6 Chi-Chin Sun,7 Jim-Ming Lee,1 Chun-Nan Yeh,4 Horng-Heng Juang21Department of General Surgery, Chang Gung ...
Wang SY, Juang HH, Chen LW, Hsu JT, Kuo SF, Sun CC, Yeh CN, Pang JHS, Chiang KC, Chen HY, Lee JM, Hsu SY, Yeh TS   +12 more
core  

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Paeoniflorin alleviates spinal cord injury in a cell model via regulating PTEN and PI3K/AKT signaling

Open Life Sciences
Spinal cord injury (SCI) is a prevalent form of spinal cord dysfunction, and the discovery of new effective treatments remains a critical research focus.
Hong Hongxiang, Xu Guanhua, Chen Jiajia, Zhang Jinlong, Ji Chunyan, Cui Zhiming   +5 more
doaj   +1 more source