Results 171 to 180 of about 147,647 (257)

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Programmable mRNA 3'UTR engineering restores MHC-I and overcomes immune evasion in prostate cancer. [PDF]

Nat Biomed Eng
Huang F, Yuan F, Li K, Cui Y, Li L, Ye W, Cui Z, Yan J, Chen Q, Nicchitta C, Zhang Y, Hankey W, Everitt J, Huang KL, Wang ME, Chen M, Huang J, Wang H, Wagner EJ, Lu X, Dong Y, Li W, Wang Q.   +22 more
europepmc   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

A catalase nanocapsule inhibits VSMCs proliferation and migration through PTEN/NLRP3 pathway. [PDF]

Front Pharmacol
Wang Y, Chen Y, Quan W, Sun T, Shi Z, Tuo Q.   +5 more
europepmc   +1 more source

Sleep profiles in individuals with rare neurogenetic syndromes

Developmental Medicine &Child Neurology, EarlyView.
Aim To characterize sleep profiles in individuals with neurogenetic disorders (NGDs) and examine the contribution of key clinical and psychiatric symptoms to these profiles. Method The parents of 248 individuals (aged 3–45 years) diagnosed with a range of NGDs, including PTEN hamartoma tumor syndrome (n = 111), SYNGAP1‐related intellectual disability ...
Isabella C. Reyes, Thomas W. Frazier, Antonio Y. Hardan, Lacey Chetcuti, Samuel J. R. A. Chawner, Emily Spackman, Mirko Uljarević, Emma K. Baker   +7 more
wiley   +1 more source

Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination. [PDF]

EMBO Mol Med
Len-Tayon K, Gantzer J, Dariane C, Fogel O, Friedrich V, Rovito D, Lindner V, Gilbart V, Yanushko D, Henri S, Metzger D, Laverny G.   +11 more
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

miR-181a-5p of MSCs-derived exosomes promote vascular formation and cell proliferation by PTEN/PI3K/AKT axis in HUVECs. [PDF]

Sci Rep
Shi W, Li Q, Dong X, Du Y, Fu Y, Huang X, Li Z.   +6 more
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

PTEN restrains SHH medulloblastoma growth through cell autonomous and nonautonomous mechanisms. [PDF]

Elife
Lao Z, El Nagar S, Liang Y, Stephen D, Joyner AL.   +4 more
europepmc   +1 more source