Results 191 to 200 of about 147,647 (257)

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

RVG-Modified BMSCs-Derived Small Extracellular Vesicles Loaded With miR-21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia. [PDF]

J Extracell Vesicles
Li Y, Hu J, Chen J, Zhou M, Liao M, Yang Y, Zhou J, Han Y, Wang B, Zhao Y.   +9 more
europepmc   +1 more source

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer

Histopathology, EarlyView.
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar, Myrthe de Waard‐van Baardwijk, Marit de Haan, Gregory van Beek, Karishma Lila, Martin E van Royen, Thierry PP van den Bosch, Mathijs A Sanders, Eric Bindels, Andrew Stubbs, Geert JLH van Leenders   +10 more
wiley   +1 more source

Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. [PDF]

J Mol Histol
Yu Y, Fang M, Shen C.
europepmc   +1 more source

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ+CD4−CD8− Double Negative T Cells in lpr Lupus Mice

Immunology, EarlyView.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

Remarkable response of metaplastic breast cancer to a novel targeted AKT inhibitor TAS-117 in a Cowden syndrome patient: a case report. [PDF]

BJC Rep
Godina E, Fernández Carcaño M, Uzunparmak B, Pepper T, Shah P, Rodon J.   +5 more
europepmc   +1 more source

Urinary extracellular vesicle miRNA signature reflects pancreatic islet stress in type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
Urinary ECV miRNAs show a distinct dysregulation signature in T2D with strong diagnostic performance. This signature mirrors molecular changes across pancreatic islets, blood, liver, and adipose tissue, with the strongest concordance in islets, linking it to β‐cell stress. Overall, they represent a non‐invasive, mechanistically informative biomarker of
Md. Zubbair Malik, Mohammed Dashti, Anwar Mohammad, Mohamed Al‐Sayegh, Mohammed Al‐Onaizi, Rasheeba Nizam, Khadija M Dashti, Mohamed Abu‐Farha, Jehad Abubaker, Fahd Al‐Mulla, Hamad Ali   +10 more
wiley   +1 more source

NSD1-Mediated PPARγ Methylation Enhances PTEN Activity to Suppress Glycolysis and Tumor Progression in Endometrial Cancer. [PDF]

Cancer Res
Tao H, Gu Y, Wang X, Sun Y, Wang L, Dai Y, Zhu M, Hu Z, Li Y, Kong M, Gao K, Wan X.   +11 more
europepmc   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

The RhoG-Binding Domain of ELMO1 Rescues the PTENopathy-like Phenotype in Oligodendroglial FBD-102b Cells. [PDF]

Int J Mol Sci
Takahashi M, Tanaka M, Yako H, Miyamoto Y, Yamauchi J.   +4 more
europepmc   +1 more source