Results 191 to 200 of about 164,611 (306)

Correlation between PI3K/PDK1/AKT pathway-related protein levels and sperm motility in Duroc Boars. [PDF]

J Anim Sci Technol
Jang SI, Jo JH, Uwamahoro C, Jung EJ, Lee WJ, Bae JW, Park C, Yi J, Kim D, Moon J, Oh DY, Ha JJ, Kwon WS.   +12 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Distinct Associations of PTEN and TMPRSS4 Expression with Clinical Outcomes and Fudan Immunohistochemistry-Based Subtypes in Triple-Negative Breast Cancer. [PDF]

Life (Basel)
Hou W, Zhang S, Wei X, Zhou L, Diao X, Liu Y, Ma X.   +6 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

The clinical and phenotypic spectrum of PTEN hamartoma tumor syndrome: a retrospective cohort study. [PDF]

Fam Cancer
Ritter E, Shtaya AA, Kariv R, Lieberman S, Half E, Postnikov M, Rosner G, Strul H, Gluck N, Katz L, Levy-Lahad E, May D, Laish I, Goldberg Y, Vainer E, Levi Z, Golan MA.   +16 more
europepmc   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Targeted Hotspot Mutation Analysis of KRAS, TP53, and PTEN in Endometrial Cancer Revealed by Next-Generation Sequencing. [PDF]

Curr Oncol
Hussain SS, Amin ZA.
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Oral Manifestations of Cowden Syndrome in a Young Patient: A Case Report With Clinical, Histological, and Genetic Findings. [PDF]

Case Rep Dent
Podda GM, Borghetti L, Rocchetti F, Di Giosaffatte N, Bottillo I, Grammatico P, Di Gioia CRT, Romeo U.   +7 more
europepmc   +1 more source

Concordance Study on Molecular Detection of Thyroid Nodules by Ultrasound Guided Fine Needle Aspiration

Journal of Clinical Laboratory Analysis, EarlyView.
This prospective study evaluated the performance of DNA and RNA next‐generation sequencing (NGS) using matched fine‐needle aspiration (FNA) and surgical tissue samples from an analysis cohort of 76 patients. ABSTRACT Background Fine needle aspiration (FNA) constitutes the primary preoperative evaluation for thyroid nodules.
Su Meng, Jianxiong Sun, Changliang Zhang, Zhixue Yang, Jinrong Wei, Si Chen, Yanan Li, Xiaoxiao Dai, Guoqin Jiang   +8 more
wiley   +1 more source