Results 211 to 220 of about 147,647 (257)

Correction: Expression of Concern: Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Retraction: NFIC suppressed the development of Glioma via modulating the balance of SHP2/PI3K and NF-κB/PTEN Signaling. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Serum levels of PTEN and progranulin as potential diagnostic and prognostic biomarkers for severe pneumonia in the elderly. [PDF]

PeerJ
Ge Y, Lu W, Liu J, Liang H, Xu L.
europepmc   +1 more source

Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss. [PDF]

Cell Rep Methods
Kalla J, Dillinger T, Pavlovicova Z, Jacob R, Atas E, Mišura K, Baskan A, Draganić K, Tiefenbacher A, Limberger T, Mair T, Wasinger G, Villanti L, Kubicek S, Kenner L, Egger G.   +15 more
europepmc   +1 more source

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer. [PDF]

Cancer Res
Burge RA, Bialousow L, Linke AJ, Coalson HS, Adair SJ, Sundararaj K, Smith M, Bumbleburg C, Bauer TW, Kashatus DF, Hobbs GA.   +10 more
europepmc   +1 more source

PTEN

, 2010
The PTEN phosphatase has an active site motif characteristic for the protein tyrosine phosphatase superfamily, yet its major substrate is the membrane lipid phosphatidylinositol (3,4,5) trisphosphate (PIP3). PTEN is thus the major antagonist of PI3 kinase signaling, which explains its supreme role in tumor suppression, development, and growth control ...
Trotman, L. C., Lloyd C. Trotman
openaire   +3 more sources

PTEN “meets” DMSO

Leukemia Research, 2005
0 d hysiological PTEN substrate is the lipidic second messener phosphatidylinositol-3,4,5-trisphosphate (PIP3). Thus, TEN reverts the phosphoinositide-3-kinases (PI3K) phoshorilation of phosphatidylinositol-4,5-bisphosphate (PIP2) o PIP3. As PIP3 activates the serine–threonine kinase Akt, hich is involved in anti-apoptosis, proliferation and oncoenesis,
Santos, Nuno C., Martins e Silva, João, Saldanha, Carlota   +2 more
openaire   +4 more sources

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PTEN in Immunity

2022
The tumor suppressor PTEN (Phosphatase and Tensin homolog deleted on Chromosome 10) executes critical biological functions that limit cellular growth and proliferation. PTEN inhibits activation of the proto-oncogenic PI3K pathway and is required during embryogenesis and to suppress tumor formation and cancer progression throughout life.
Antonella, Papa, Pier Paolo, Pandolfi
openaire   +2 more sources

PTEN and Melanomagenesis

Future Oncology, 2012
The PI3K-PTEN-AKT signaling pathway is involved in various cellular activities, including proliferation, migration, cell growth, cell survival and differentiation during adult homeostasis as well as in tumorigenesis. It has been suggested that the constitutive activation of PI3K/AKT signaling with concurrent loss of function of the tumor suppressor ...
Alejandro, Conde-Perez, Lionel, Larue
openaire   +2 more sources

PTEN and Cancer

2003
Genetic evidence strongly suggested that a tumor suppressor was located on chromosome 10. During the development of glioblastoma, one copy of chromosome 10 was typically lost (1). Cytogenetic and molecular analysis revealed partial or complete loss of chromosome 10 in bladder, endometrial, and prostate cancer (2,3).
Ramon, Parsons, Laura, Simpson
openaire   +2 more sources