Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells. [PDF]
Sci RepChen AY, Rudensky AY.
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Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
miR-200a-3p Alleviates Neuroinflammation and Oxidative Stress in Spinal Cord Injury via PTEN Targeting: A Potential Diagnostic Biomarker. [PDF]
Global Spine JLiu G, Qiu R, Wang G, Xu H, Zhang J.
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The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
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An Update on Early‐Onset Breast Cancer: Incidence, Risk Factors, Genetic Testing, and Treatment
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Early‐onset breast cancer presents in patients typically under the age of 40, while very early‐onset breast cancer is usually viewed as breast cancer occurring before the age of 35. Early‐onset breast cancer demonstrates specific molecular properties and has worse outcomes compared to its late‐onset breast cancer counterpart.
Leila Jahangiri
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Expression of PTEN and p53 and Their Clinicopathological Correlation in Breast Cancer. [PDF]
CureusPurohit T, Sahu S, Dandekar M, Verma D.
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International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho +7 more
wiley +1 more source
A Case Report: Effects of a ketogenic diet on PTEN mutation-associated autism spectrum disorder. [PDF]
Front NutrWang Y +9 more
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Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Lactylation‐mediated metabolism reprogramming in HCC sorafenib resistance. In sorafenib‐resistant hepatocellular carcinoma (HCC) cells, lactate accumulation drives histone H3 lysine 18 lactylation (H3K18la). This modification is specifically enriched in the promoter region of homeobox B13 (HOXB13), activating HOXB13 transcription and upregulating its ...
Qingqing Xie +5 more
wiley +1 more source
Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes <i>SOCS1, PTEN</i> and <i>PIAS3</i>. [PDF]
Front ImmunolEspinoza-García N +9 more
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