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Journal of Clinical Pathology, 2022
PTEN is a well-known tumour suppressor protein that is frequently found to be mutated, inactivated or deleted in a wide range of different cancers. Its tumour suppressive properties result predominantly from its inhibitory effects on the PI3K-AKT signalling pathway.
Furkan Akif Ince +2 more
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PTEN is a well-known tumour suppressor protein that is frequently found to be mutated, inactivated or deleted in a wide range of different cancers. Its tumour suppressive properties result predominantly from its inhibitory effects on the PI3K-AKT signalling pathway.
Furkan Akif Ince +2 more
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Blood, 2012
Regulation of the Pten tumor suppressor is complex and mediated by varied mechanisms. In this issue of Blood , Wey and colleagues show in a biallelic conditional knockout mouse model of GRP78 and PTEN that heterozygous loss of Grp78 suppresses leukemogenesis mediated by Pten .[1][1] These ...
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Regulation of the Pten tumor suppressor is complex and mediated by varied mechanisms. In this issue of Blood , Wey and colleagues show in a biallelic conditional knockout mouse model of GRP78 and PTEN that heterozygous loss of Grp78 suppresses leukemogenesis mediated by Pten .[1][1] These ...
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Biochemical Society Transactions, 2007
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. In dephosphorylating the 3-position of the inositol ring of phosphoinositides such as PtdIns(3,4,5)P3, PTEN's lipid phosphatase activity is an important counteracting mechanism in PI3K (phosphoinositide 3-kinase) signalling. This is essential for cell
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PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. In dephosphorylating the 3-position of the inositol ring of phosphoinositides such as PtdIns(3,4,5)P3, PTEN's lipid phosphatase activity is an important counteracting mechanism in PI3K (phosphoinositide 3-kinase) signalling. This is essential for cell
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Methods, 2015
PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed secreted and available for uptake by other cells in at least two different guises.
Putz, Ulrich +5 more
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PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed secreted and available for uptake by other cells in at least two different guises.
Putz, Ulrich +5 more
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Journal of Clinical Pathology, 2012
Phosphatase and tensin homologue deleted on chromosome 10 ( PTEN ), also referred to as mutated in multiple advanced cancers ( MMAC1 ) and TGF-β regulated and epithelial cell enriched phosphatase ( TEP1 ), was first discovered in 1997.1–3 Since its discovery, an entire network of interconnections to various other cellular pathways has been uncovered ...
Dhirendra, Govender, Runjan, Chetty
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Phosphatase and tensin homologue deleted on chromosome 10 ( PTEN ), also referred to as mutated in multiple advanced cancers ( MMAC1 ) and TGF-β regulated and epithelial cell enriched phosphatase ( TEP1 ), was first discovered in 1997.1–3 Since its discovery, an entire network of interconnections to various other cellular pathways has been uncovered ...
Dhirendra, Govender, Runjan, Chetty
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Expression of PTEN and PTEN pseudogene in endometrial carcinoma.
International Journal of Molecular Medicine, 2000PTEN is a tumor suppressor gene and its mutation is frequently found in endometrial carcinoma. Recently, the pseudogene of PTEN has been reported to be actively transcribed in a number of cells and tissues and a potential for translation is suggested.
Y, Yokoyama +6 more
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Cold Spring Harbor Perspectives in Medicine, 2019
For years, clinical and basic researchers have been aware of the presence of PTEN in the nucleus in cell culture, animal models, and both healthy and diseased human tissues. Despite the early recognition of nuclear PTEN, the understanding of the mechanisms of its nuclear localization, function in the nucleus, and importance in biology and human disease
Jason, Ho +3 more
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For years, clinical and basic researchers have been aware of the presence of PTEN in the nucleus in cell culture, animal models, and both healthy and diseased human tissues. Despite the early recognition of nuclear PTEN, the understanding of the mechanisms of its nuclear localization, function in the nucleus, and importance in biology and human disease
Jason, Ho +3 more
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Regulation of the PTEN phosphatase
Gene, 2006Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatidylinositol phosphate phosphatase and is frequently inactivated in human cancers. The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P3 levels. PI3K is regulated by a variety of intracellular and extracellular signals, but little is known about
Arne, Gericke +2 more
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Expert Review of Neurotherapeutics, 2008
The tumor suppressor PTEN dephosphorylates phospholipids generated through the activity of PI3K. PTEN thus antagonizes PI3K activity and regulates a multitude of cellular processes such as angiogenesis, motility, invasiveness, survival and proliferation, all of which can initiate and sustain the malignant phenotype.
Daphne, Haas-Kogan, David, Stokoe
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The tumor suppressor PTEN dephosphorylates phospholipids generated through the activity of PI3K. PTEN thus antagonizes PI3K activity and regulates a multitude of cellular processes such as angiogenesis, motility, invasiveness, survival and proliferation, all of which can initiate and sustain the malignant phenotype.
Daphne, Haas-Kogan, David, Stokoe
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Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas
International Journal of Oncology, 2002New therapeutic strategies are needed to improve survival in glioblastoma (GBM) the most malignant astrocytic tumor. We evaluated: a) the genetic status of 22 GBMs by comparative genomic hybridization (CGH); b) the specific role of mutation and/or homozygous deletion of PTEN in the genesis of GBM; and c) the possible therapeutic role of PTEN against ...
Xing, Fan +5 more
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