Results 221 to 230 of about 224,722 (300)

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

PTEN-mTORC2 signaling module controls antibody isotype selection and antiviral humoral immunity. [PDF]

Front Immunol
Thapa B, Lee Y, Pak S, Kim D, Kwon HJ, Lee K.   +5 more
europepmc   +1 more source

Hematopoietic Stem Cells Require Elevated Protein Quality Control [PDF]

, 2018
Dillingham, Christopher, Hatters, Danny, Hong, Yuning, Kruta, Miriama, San Jose, Lorena Hidalgo, Signer, Robert, Sunshine, Mary Jean   +6 more
core  

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

PTEN enhances the radiosensitivity of melanoma by inhibiting DNA-PKcs. [PDF]

Front Cell Dev Biol
Zhu S, Xu H, Shen F, Chen F, Wang Y.
europepmc   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells. [PDF]

Oncol Rep
Fu W, Lin L, Li J, Qin F, Chen C, Cai Y, Cai Y, Huang Y, Yang W, Zhu S.   +9 more
europepmc   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar, William P. D. Hendricks, David Rainford, William Selleck, Natalia Briones, Christopher Coggins, Natalie Quan, Victoria Zismann, Gwendolen Lorch, Aleksandar Sekulic, Jeffrey M. Trent   +10 more
wiley   +1 more source

Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome. [PDF]

Dis Model Mech
Tibarewal P, Rathbone V, Conduit SE, Classen GAE, Black F, Danesh MA, Constantinou G, Asgarian Z, Tohyama K, Kriplani N, Garcia VA, Foxall E, Belarbi D, Leverve M, Pearce W, Adil M, Varyova Z, Conde L, Alves A, Masson GR, Williams RL, Flanagan AM, Herrero J, Mohamed IA, Stroud K, Tischkowitz M, Lachlan K, Scudamore CL, Scott MGH, Leslie NR, Kessaris N, Vanhaesebroeck B.   +31 more
europepmc   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source