Results 121 to 130 of about 164,611 (306)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling

Open Life Sciences, 2023
Li Guilong, Cai Jiaying, Xie Jianjun, Dai Yizhi   +3 more
doaj   +1 more source

Alhagi maurorum Extract Regulates the PI3K/AKT Cascade and Inhibits the Proliferation of the Lung Cancer Cell Line

Advanced Biomedical Research
Background: This study investigates the anticancer effects of hydroalcoholic Alhagi maurorum extract on non-small-cell lung cancer. Materials and Methods: Signaling pathways in non-small-cell lung cancer were analyzed using the EnrichR website and KEGG ...
Fereshteh Ramezani Zardanjani, Hajar Yaghoobi, Abbas Alibakhshi, Sayedeh Azimeh Hosseini, Nayereh Bahamin   +4 more
doaj   +1 more source

Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice

, 2012
Zhongbing Liu, Jinwei Li, Juan Li, Juan Huang, Famin Ke, Qiaona Qi, Xing Jiang, Zhirong ZhongLuzhou Medical College, Luzhou, Sichuan, People's Republic of ChinaBackground: It has been reported that the tumor suppressor gene, PTEN, which is ...
Liu Z, Li J, Ke F, Huang J, Jiang X, Zhong Z, Qi Q   +6 more
core  

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

The expression level of miR-21, a target of the PTEN gene receptor in the PI3K signaling pathway, in clinical samples of triple negative breast cancer [PDF]

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Triple negative breast cancer (TNBC) is an aggressive form of breast cancer, necessitating effective treatment methods. This study aimed to assess the expression level of miR-21, a target of the Phosphatase and tensin homolog (PTEN ...
Javad Razaviyan, Razieh Hadavi, Melika Tafti, Samira Mohammadi-Yeganeh   +3 more
doaj  

PTEN regulates Maf1 protein expression.

, 2014
(A) Maf1 expression is decreased in mouse cells and tissues lacking PTEN. Protein lysates were isolated from wild-type and Pten−/− MEFs; livers of 1 month old PtenloxP/loxP; Alb-Cre− (+/+; n = 4) and PtenloxP/loxP; Alb-Cre+ (−/−; n = 3) mice; and ...
Louis Dubeau (193226), Bangyan L. Stiles (562564), Aarti D. Rohira (673046), Beth M. Palian (673045), Sandra A. S. Johnson (673047), Ni Zheng (332084), Lina He (257060), Deborah L. Johnson (673048)   +7 more
core   +1 more source

Pten dose dictates cancer progression in the prostate. [PDF]

, 2003
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation.
Andrew Xiao, Xiao, Andrew, Khoo, Alan S, Niki, M., Pandolfi, P. P., Pandolfi, Pier Paolo, Antonio Di Cristofano, Di Cristofano, A., Van Dyke, T., Terry Van Dyke, Zohar A Dotan, Dyke, Terry Van, Carlos Cordon-Cardo, Trotman, L. C., Dotan, Z. A., Norman M Greenberg, Xiao, A., Roy-Burman, P., Pier Paolo Pandolfi, Greenberg, Norman M, Lloyd C Trotman, Dotan, Zohar A, Trotman, Lloyd C, Cordon-Cardo, Carlos, Koutcher, Jason A, Khoo, A. S., Niki, Masaru, Cordon-Cardo, C., Greenberg, N. M., Di Cristofano, Antonio, Roy-Burman, Pradip, Masaru Niki, Jason A Koutcher, Koutcher, J. A., Pradip Roy-Burman, Alan S Khoo   +35 more
core   +2 more sources

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source