Results 111 to 120 of about 224,722 (300)

Value of PTEN and Echocardiography in Predicting the Efficacy of Trimetazidine Combined with Metoprolol in the Treatment of Heart Failure

open access: yesInternational Journal of General Medicine, 2021
Xue-Hong Feng,1 Yang Wang,1 Lian-Yu Wang,1 Jun-Fei Shen,1 Chun-Yuan You,1 Qiu-Ting Feng2 1Department of Echocardiography, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214002, People’s Republic of China; 2Department
Feng XH   +5 more
doaj  

In vivo characterization of hippocampal electrophysiological processes in the heterozygous Pten knockout model of autism [PDF]

open access: yes, 2018
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism, little work has been done to demonstrate how corresponding in vitro physiological alterations in this model may underpin these cognitive deficits in ...
Barry, Jeremy   +2 more
core   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

open access: yesAnimal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao   +12 more
wiley   +1 more source

Correlation between the presence of the nuclear AR-V7 androgen receptor and clinical evolution of prostate cancer: in vitro analysis of a combination of compounds targeting PI3K [PDF]

open access: yes, 2019
Introduzione: PCa è una malattia multiforme e biologicamente molto eterogenea. Diversi meccanismi chiave nella progressione della malattia da androgeno-dipendente ad androgeno-indipendente (CRCP) possono essere attribuiti ad alterazione nella via di ...
Cattarino, Susanna
core  

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

open access: yesArthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco   +11 more
wiley   +1 more source

Alhagi maurorum Extract Regulates the PI3K/AKT Cascade and Inhibits the Proliferation of the Lung Cancer Cell Line

open access: yesAdvanced Biomedical Research
Background: This study investigates the anticancer effects of hydroalcoholic Alhagi maurorum extract on non-small-cell lung cancer. Materials and Methods: Signaling pathways in non-small-cell lung cancer were analyzed using the EnrichR website and KEGG ...
Fereshteh Ramezani Zardanjani   +4 more
doaj   +1 more source

Multiple Meningiomas in a Patient with Cowden Syndrome

open access: yesJournal of Neurological Surgery Reports, 2016
Background Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear.
Margaret Pain   +3 more
doaj   +1 more source

The Role of Microbiota Metabolites Propionic Acid, p‐Cresol, and 4‐Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review

open access: yesAutism Research, EarlyView.
ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni   +6 more
wiley   +1 more source

The expression level of miR-21, a target of the PTEN gene receptor in the PI3K signaling pathway, in clinical samples of triple negative breast cancer [PDF]

open access: yesمجله علوم پزشکی فیض (پیوسته)
Background and Aim: Triple negative breast cancer (TNBC) is an aggressive form of breast cancer, necessitating effective treatment methods. This study aimed to assess the expression level of miR-21, a target of the Phosphatase and tensin homolog (PTEN ...
Javad Razaviyan   +3 more
doaj  

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