Results 91 to 100 of about 164,611 (306)
, 2014 A) PTEN protein levels in CML blast crisis. Jurkat cell line was used as a PTEN null cell line. B) Chromatogram from sanger sequencing analysis of PTEN in the EM2 cell line. C) Schematic representation of PTEN.
Sabrina Crivellaro (649162) +5 more
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Psychiatric Characteristics Across Individuals With PTEN Mutations
, 2021 Germline heterozygous PTEN mutations have been associated with high prevalence of autism spectrum disorder (ASD) and elevated rates and severity of broadly defined behavioral problems.
P Klaas (11527609) +12 more
core +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
Investigation of PTEN promoter methylation in ameloblastoma [PDF]
, 2020 Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene. Inactivation of PTEN has been reported in various types of cancers. PTEN promoter methylation possibly underlies PTEN inactivation, which results in tumorigenesis.
Lapthanasupkul, Puangwan +3 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
, 2017 Example of immunohistochemical detection of PTEN: A: Negative PTEN expression (IRS 1); B: Positive PTEN expression (IRS 2).
Daphne Gschwantler-Kaulich (395260) +11 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays
Advanced Functional Materials, EarlyView.Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao +7 more
wiley +1 more source
Cells, 2019 Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior ...
Giovanna Carrà +3 more
doaj +1 more source
Single-molecule imaging of wild-type PTEN and PTENi mutants.
, 2014 (A) Images of cells expressing wild-type PTEN or PTENi mutants labeled with TMR captured under TIRFM. Scale bar, 5 µm. (B) The numbers of PTEN-Halo-TMR and PTENi-Halo-TMR molecules that remained bound to the membrane are plotted against time after ...
Masahiro Ueda (103479) +2 more
core +1 more source