Results 101 to 110 of about 147,647 (257)

Upstream activation of PTEN

, 2013
The PTEN tumor suppressor is among the most frequently altered genes of cancer. PTEN suppression at the protein level is critically associated with disease since PTEN is haploinsufficient in many cancer types, including prostate.
Lazar, Z., Gyula Bencze, Ruse, C. I., Naguib, A., Joshua-Tor, L., Bencze, G., Leemor Joshua-Tor, Lloyd C. Trotman, Christopher R. Faehnle, Zsolt Lazar, Faehnle, C. R., Pappin, D. J., Trotman, L. C., Adam Naguib, Schalch, T., Darryl J. Pappin, Thomas Schalch, Cristian I. Ruse   +17 more
core   +1 more source

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

, 2015
Kun-Chun Chiang,1,4 Huang-Yang Chen,1 Shu-Yuan Hsu,2 Jong-Hwei S Pang,3 Shang-Yu Wang,4 Jun-Te Hsu,4 Ta-Sen Yeh,4 Li-Wei Chen,5 Sheng-Fong Kuo,6 Chi-Chin Sun,7 Jim-Ming Lee,1 Chun-Nan Yeh,4 Horng-Heng Juang21Department of General Surgery, Chang Gung ...
Wang SY, Juang HH, Chen LW, Hsu JT, Kuo SF, Sun CC, Yeh CN, Pang JHS, Chiang KC, Chen HY, Lee JM, Hsu SY, Yeh TS   +12 more
core  

Berberine alleviates pyroptosis of retinal ganglion cells in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source

Example of immunohistochemical detection of PTEN: A: Negative PTEN expression (IRS 1); B: Positive PTEN expression (IRS 2).

, 2017
Example of immunohistochemical detection of PTEN: A: Negative PTEN expression (IRS 1); B: Positive PTEN expression (IRS 2).
Daphne Gschwantler-Kaulich (395260), Carmen Leser (3809554), Eva-Maria Fuchs (291887), Wolfgang J. Köstler (291889), Yen Y. Tan (3809560), Gernot Hudelist (3809557), Johannes Attems (547213), Christoph C. Zielinski (619430), Angelika Reiner (3809548), Mohamed Salama (667415), Christine Deutschmann (3809551), Christian F. Singer (308365)   +11 more
core   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

PTEN -ekspressio rintasyövässä [PDF]

, 2006
Tutkimuksen tausta ja tavoitteet: HER2 on pahanlaatuista solukasvua aiheuttava syöpägeeni, jonka geenimonistumaa ja/tai sen koodaaman reseptoriproteiinin yliekspressiota esiintyy rintasyövässä sekä myös eräissä muissa syöpätyypeissä.
KÖNINKI, KATRI
core  

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension

, 2017
HaiTao Liu, Tao Yin, Wenjun Yan, Rui Si, Bo Wang, Mai Chen, Fei Li, Qiong Wang, Ling Tao Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China Abstract: Hypoxia-induced ...
Liu H, Tao L, Wang Q, Yin T, Wang B, Chen M, Li F, Yan W, Si R   +8 more
core  

Diagnostic accuracy of phosphatase and tensin homolog loss in differentiating between atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia and non‐atypical endometrial hyperplasia: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Accurate distinction between atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN) and non‐atypical endometrial hyperplasia (EH) determines whether patients require hysterectomy or can be managed conservatively.
Kristina Shcherbatiuk, Steffi Bultmann, Thomas Karn, Khayal Gasimli, Peter Wild, Sven Becker, Morva Tahmasbi Rad   +6 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source