Results 101 to 110 of about 164,611 (306)
Advanced Healthcare Materials, EarlyView.Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran +15 more
wiley +1 more source
Characterization of Ad.DD3.D55-PTEN.
, 2013 A. Schematic diagram of Ad.DD3.D55-PTEN. The endogenous promoter of E1A was replaced by the DD3 promoter, and the E1B-55K gene was deleted. The PTEN expression cassette was inserted into Ad.DD3.D55 to construct Ad.DD3.D55-PTEN.
Miao Ding (326736) +9 more
core +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
PTEN expression in patient tumor samples.
, 2015 PTEN immunohistochemical staining in a representative PTEN-positive tumor and a PTEN-negative tumor. H+E histology and CD99 immunohistochemical staining are also shown.
Janet K. Parrish (684749) +5 more
core +1 more source
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice
Clinical and Experimental Hypertension, 2017 Background: Diabetes is one of high-risk factors for cardiovascular disease. Improvement of endothelial dysfunction in diabetes reduces vascular complications. However, the underlying mechanism needs to be uncovered. This study was conducted to elucidate
Xiaona Xie +5 more
doaj +1 more source
, 2001 Nell’ambito del progetto presentato l'unità del prof. Pucci (UO4) si occuperà essenzialmente di 2 aspetti della via di trasduzione del segnale trasmesso dalla via PI3K/PTEN/AKT: 1.
PUCCI, PIETRO
core
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
The role of factors involved in proliferation processes in the pathogenesis of adenomyosis
Сибирский научный медицинский журналThe study of the expression of proliferation factors by immunohistochemistry is necessary to determine their role in the pathogenesis of the disease and to develop new diagnostic methods and pathogenetically based therapy.
A. K. Beganova +4 more
doaj +1 more source
Drug Design, Development and Therapy, 2021 Yi Wu,1 Zhong Zhang,2 Zuqiang Kou3 1Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, 110004, People’s Republic of China; 2Department of Pathology, Shenyang Medical College, Shenyang City, Liaoning Province ...
Wu Y, Zhang Z, Kou Z
doaj