Results 101 to 110 of about 224,722 (300)

Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice

Clinical and Experimental Hypertension, 2017
Background: Diabetes is one of high-risk factors for cardiovascular disease. Improvement of endothelial dysfunction in diabetes reduces vascular complications. However, the underlying mechanism needs to be uncovered. This study was conducted to elucidate
Xiaona Xie, Wanchun Sun, Jun Wang, Xiaoou Li, Xiaofeng Liu, Ning Liu   +5 more
doaj   +1 more source

Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair, Kevin Carratu, Natalie E. Rintoul, Holly L. Hedrick, William H. Peranteau, Catherine M. Avitabile, Kirsty McWalter, Paul Kruszka, Ian D. Krantz, K. Taylor Wild   +9 more
wiley   +1 more source

The role of factors involved in proliferation processes in the pathogenesis of adenomyosis

Сибирский научный медицинский журнал
The study of the expression of proliferation factors by immunohistochemistry is necessary to determine their role in the pathogenesis of the disease and to develop new diagnostic methods and pathogenetically based therapy.
A. K. Beganova, M. I. Yarmolinskaya, M. A. Shalina, T. G. Tral, G. Kh. Tolibova   +4 more
doaj   +1 more source

Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro

Drug Design, Development and Therapy, 2021
Yi Wu,1 Zhong Zhang,2 Zuqiang Kou3 1Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, 110004, People’s Republic of China; 2Department of Pathology, Shenyang Medical College, Shenyang City, Liaoning Province ...
Wu Y, Zhang Z, Kou Z
doaj  

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Deletion of Cardiac miR-17-92 Cluster Increases Ischemia/ Reperfusion Injury via PTEN Upregulation [PDF]

, 2017
The miR-17- 92 cluster is necessary for cell proliferation and development of the cardiovascular system. Deletion of this cluster leads to death in neonatal mice.
Prakash, Meeta B
core   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Pten in mouse vagina

Oncoscience, 2015
It is well known that the phosphatase and tensin homolog deleted from chromosome 10 (Pten) is a tumor suppressor and is indispensable for epithelial cell homeostasis to prevent tumor formation. Mutations in Pten are frequently found both in sporadic and hereditary cancers, and mice with Pten deletion and/or loss-of-function mutations are highly ...
Shinichi, Miyagawa, Taisen, Iguchi
openaire   +2 more sources

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objective: Physical activity and diet are the most important modifiable determinants of cancer risk. The aim of this study was to investigate the comparison of the effect of vitamin E on the expression of p53/PTEN prostate gland of male rats
Amin Allah Dashtiyan, Mohammad Esmaeil Afzalpour, Nader Tanideh, Masood Sepehrimanesh   +3 more
doaj