Results 71 to 80 of about 164,611 (306)
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
, 2014 PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here, we show that PTEN homodimerizes and, in this active conformation, exerts lipid phosphatase activity on PtdIns(3,4,5)P3.
Beck AH +18 more
core +2 more sources
In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself [PDF]
, 2018 Background Loss of PTEN is involved in tumor progression of several tumor entities including renal cell carcinoma (RCC). During the translation process PTEN generates a number of splice variants, including PTEN-Δ.
Sebastian Frees +8 more
core +2 more sources
USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma
Cancer Management and Research, 2019 Zhi Qu1, Ran Zhang2, Meng Su2, Weixian Liu1 1Department of Oral and Maxillofacial Surgery, Shengjing Hospital, China Medical University, Shenyang, China; 2Department of Prosthodontics, Second Affiliated Hospital ...
Qu Z, Zhang R, Su M, Liu W
doaj
Oncoscience, 2015 It is well known that the phosphatase and tensin homolog deleted from chromosome 10 (Pten) is a tumor suppressor and is indispensable for epithelial cell homeostasis to prevent tumor formation. Mutations in Pten are frequently found both in sporadic and hereditary cancers, and mice with Pten deletion and/or loss-of-function mutations are highly ...
Shinichi, Miyagawa, Taisen, Iguchi
openaire +2 more sources
Bedeutung der PTEN-Splice Variante PTEN-Delta für die Tumorprogression [PDF]
, 2017 Das Tumorsuppressorprotein PTEN spielt in vielen verschiedenen Tumorentitäten, wie auch dem Nierenzellkarzinom, eine wichtige Rolle in der Tumorprogression. Während der Translation bildet PTEN mehrere Splice-Varianten aus, unter anderem auch die Variante
Breuksch, Ines
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular landscape of borderline ovarian tumours: A systematic review
Open MedicineBorderline ovarian tumours (BOTs) show intriguing characteristics distinguishing them from other ovarian tumours. The aim of the systematic review was to analyse the spectrum of molecular changes found in BOTs and discuss their significance in the ...
Sadlecki Pawel +1 more
doaj +1 more source
The Role of PTEN in Neurodevelopment [PDF]
Complex Psychiatry, 2019 PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurodevelopment.
Patrick D. Skelton +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Zhongliu Fangzhi Yanjiu, 2020 Objective To investigate the effect of miR-214 on the apoptosis of nasopharyngeal carcinoma (NPC) cells by regulating the activation of AKT signaling pathway through targeting PTEN.
HAN Jibo +4 more
doaj +1 more source