Results 61 to 70 of about 164,611 (306)

Research Progress on PI3K/AKT/mTOR Signaling Pathway in Burkitt Lymphoma

Zhongliu Fangzhi Yanjiu, 2019
Burkitt lymphoma is a highly aggressive subtype of non-Hodgkin lymphoma. And it is one of the fastest growing human tumors. The lymphoma can be divided into three subclasses: endemic type, sporadic type and immunodeficiency-associated type, according to ...
SUN Yuanyuan, ZHANG Mingzhi
doaj   +1 more source

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma

Molecular & Cellular Oncology, 2020
High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB ...
Mirentxu Santos
doaj   +1 more source

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori [PDF]

BioImpacts, 2020
Introduction: Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by Helicobacter pylori which could colonize within the gastric mucosa of the infected cases.
Hadi Maleki-Kakelar, Jaber Dehghani, Abolfazl Barzegari, Jaleh Barar, Masoud Shirmohamadi, Javid Sadeghi, Yadollah Omidi   +6 more
doaj   +1 more source

PTEN, here, there, everywhere [PDF]

Cell Death & Differentiation, 2013
Loss of function of the phosphatase and tensin homolog (PTEN) tumor suppressor is frequently found in many human malignancies.1 PTEN antagonizes the phosphatidylinositide 3-kinase (PI3K) pathway2 by dephosphorylating the 3′ position of phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] (or PIP3).2, 3 PIP3 serves as a second messenger whose ...
C, Bassi, V, Stambolic
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

PTEN-uating Restenosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Within the last few years, the lipid phosphatase PTEN has gained increasing attention.1 Initially described as a tumor suppressor gene, the function of PTEN meanwhile ranges from the regulation of the immune system to the recently established important function in neuronal growth.1,2⇓ On a cellular level, PTEN interferes with cell proliferation ...
Stefanie, Dimmeler, Andreas M, Zeiher
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

PTEN in Chromatin Remodeling [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
openaire   +2 more sources

Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma [PDF]

, 2023
Loss of protein expression of the tumor suppressor PTEN is associated with increased cancer aggressiveness, decreased tumor immune infiltration, and resistance to immune and targeted therapies in melanoma.
Feng Wang, Lawrence N. Kwong, Davies, Michael A, De Macedo, Mariana P, Tetzlaff, Michael T, Sarah E. Warren, Beechem, Joseph M, Warren, Sarah E, Lazar, Alexander J, Ong, Giang T, Lauren E. Haydu, Peng, Weiyi, Diego M. Marzese, Gordon B. Mills, Giang T. Ong, Joseph M. Beechem, Wani, Khalida, Michael A. Davies, Mariana P. De Macedo, Khalida Wani, Kwong, Lawrence N, Marzese, Diego M, Alexander J. Lazar, Hoon, Dave S B, Sharmeen Chagani, Wang, Feng, Haydu, Lauren E, Dave S.B. Hoon, Chagani, Sharmeen, Carapeto, Fernando, Weiyi Peng, Mills, Gordon B, Fernando Carapeto, Michael T. Tetzlaff   +33 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source