Results 41 to 50 of about 147,647 (257)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pten in mouse vagina

Oncoscience, 2015
It is well known that the phosphatase and tensin homolog deleted from chromosome 10 (Pten) is a tumor suppressor and is indispensable for epithelial cell homeostasis to prevent tumor formation. Mutations in Pten are frequently found both in sporadic and hereditary cancers, and mice with Pten deletion and/or loss-of-function mutations are highly ...
Shinichi, Miyagawa, Taisen, Iguchi
openaire   +2 more sources

PTEN in Chromatin Remodeling [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
openaire   +2 more sources

Prostate-specific PTen deletion in mice activates inflammatory microRNA expression pathways in the epithelium early in hyperplasia development [PDF]

, 2017
PTen loss is one of the most frequent events in prostate cancer both at the initiation stage and during late stage metastatic development. The mouse model of prostate-specific probasin-mediated Pten deletion leads to prostate intraepithelial neoplasia ...
Uysal-Onganer, P., Jiang, W.G., W. G. Jiang, Dart Alwyn, D., Pinar Uysal-Onganer, Jiang, Wen Guo, Jiang, WG, Dart, Alwyn Dafydd, Dart, D Alwyn, Uysal-Onganer, Pinar, D. Alwyn Dart   +10 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function

, 2019
The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder).
Sandra Luna, Molina Martín, María, Jiménez Cid, Víctor, Luna, Sandra, Isabel Rodríguez-Escudero, Pulido, Rafael, Fernández-Acero, Teresa, Rodríguez-Escudero, Isabel, Teresa Fernández-Acero, Molina, María, Eleonora Bertalmio, Rodríguez Escudero, María Isabel, María Molina, Fernández-Acero Bascones, Teresa, Bravo Plaza, Ignacio, Rafael Pulido, Janire Mingo, Ignacio Bravo-Plaza, Bravo-Plaza, Ignacio, Mingo, Janire, Cid, Víctor J, Víctor J. Cid, Bertalmio, Eleonora   +22 more
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era

, 2014
Deregulation of multiple DNA repair pathways may contribute to aggressive biology and therapy resistance in gliomas. We evaluated transcript levels of 157 genes involved in DNA repair in an adult glioblastoma Test set (n=191) and validated in ‘The Cancer
Agarwal, D, Auer, Dorothee T, Lourdusamy, Anbarasu, Chan, Stephen, Ball, G, Lakhani, R, Grundy, Richard, Lourdusamy, A, Ball, Graham, Scott, Ian S, Abdel-Fatah, Tarek M.A., Auer, DT, Scott, IS, Lakhani, Ravi, Grundy, R, Walker, David, Agarwal, Devika, Abdel-Fatah, TMA, Chan, S, Scott, Ian S., Madhusudan, Srinivasan, Perry, C, Abdel-Fatah, Tarek MA, Madhusudan, S, Walker, D, Perry, Christina, Auer, Dorothee T.   +26 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

New insights into PTEN [PDF]

Journal of Cell Science, 2007
The functions ascribed to PTEN have become more diverse since its discovery as a putative phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and proteins, it also has functions independent of phosphatase activity in normal and pathological states. In addition, control of PTEN function is very complex.
Tanja, Tamguney, David, Stokoe
openaire   +2 more sources