Results 41 to 50 of about 164,611 (306)
Cells, 2020 The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to ...
Tsung-Lin Lee +6 more
doaj +1 more source
Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells
Pteridines, 2020 Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense.
Wang Hexian +6 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: To investigate the effect and potential molecular mechanisms of Dipsacoside B (DB), an herb monomer extracted from Dipsacusasper or Lonicera macranthoides, on the migration and proliferation of vascular smooth muscle cells (VSMCs) and balloon-
Wenjuan Quan +7 more
doaj +1 more source
The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity [PDF]
Molecular & Cellular Oncology, 2021 Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between
Casey G. Langdon, Mark E. Hatley
openaire +3 more sources
Journal of Inflammation Research, 2022 Fei Wu,1– 3,* Jie Chen,4,* Kang Yao,1 Daming Fan,5 Minglei Wang,2 Yongjun Liu,1 Shouhu Xin,1 Zeqiang Sun,1 Shun Li,1 Yang Sun,6 Qingyong Liu1 1Department of Urology, the First Affiliated Hospital of Shandong First Medical University, Shandong ...
Wu F +10 more
doaj
Renal Failure, 2020 Background Nephrotoxicity, especially acute kidney injury (AKI), is the main dose-limiting toxicity of cisplatin. Although recent studies showed that curcumin prevented cisplatin-induced AKI effectively, further studies to understand the mechanism are ...
Si-Jia Huang +12 more
doaj +1 more source
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood malignancy caused by changes in the precursors of T lymphocyte cells. The PTEN gene is one of the most common tumor suppressor genes that mutates in most human cancers,
Malihe Bagheri +2 more
doaj
miR-23b-3p regulates differentiation of osteoclasts by targeting PTEN via the PI3k/AKT pathway
Archives of Medical Science, 2019 Introduction Osteoblasts and osteoclasts are cells of osteoblastic origin, and are vital in homeostasis of the skeleton. miRs are important for functioning, survival and differentiation of osteoclasts.
Jiwei Chai, Liang Xu, Niansheng Liu
doaj +1 more source
The Role of PTEN in Tumor Angiogenesis [PDF]
, 2012 During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation.
Uyen Huynh-Do +5 more
core +2 more sources
Evaluation of the Expression Level of miR-32 and PTEN in Melanoma [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: The aim is to investigate the change in the expression level of miR-32 and PTEN genes in tumor samples with melanoma. Materials and methods: This study collected tumor samples from 50 patients and 50 samples from healthy marginal
Zohreh Abdolrahimi +3 more
doaj