Results 31 to 40 of about 164,611 (306)
Functional activity of PTEN isoforms and PTEN C-terminal truncations.
, 2023 (A) COS‐7 cells were transfected with pRK5 empty vector (EV) or pRK5 encoding the distinct PTEN isoforms [PTEN, PTEN-Δ, PTEN-L/-M/-O(Met)], in combination with the pSG5 HA‐AKT1 plasmid, and cells were processed for immunoblot using anti-PTEN BA226, anti ...
Leire Torices (16726432) +3 more
core +1 more source
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. [PDF]
, 2010 BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa).
P T Scardino +65 more
core +1 more source
, 2023 Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources.
N. U. Farrukh Hameed (10001728) +15 more
core +1 more source
Case Reports in Oncology, 2020 Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment.
Jamie A. Kmak +8 more
doaj +1 more source
PTEN regulation by Akt–EGR1–ARF–PTEN axis [PDF]
The EMBO Journal, 2008 The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes. Here, we describe a novel Akt-EGR1-alternate reading frame (ARF)-PTEN axis, in which PTEN activation in vivo requires p14ARF-mediated sumoylation of ...
Jianxiu, Yu +11 more
openaire +2 more sources
Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function [PDF]
, 2019 The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder).
Sandra Luna +22 more
core +1 more source
Indian Journal of Pathology and Microbiology, 2023 Objective: This article aims to study the effect of phosphate and tension homolog deleted on chromosome ten (PTEN) knockdown on colon cancer progression and macrophage polarization in the cancer environment.
Xu Han +4 more
doaj +1 more source
The nuclear affairs of PTEN [PDF]
Journal of Cell Science, 2008 PTEN encodes a major tumor-suppressor protein that is a dual-specificity phosphatase. Inactivation of PTEN has been shown to be involved in heritable and sporadic cancers. Mutation or deletion of PTEN, historically the most commonly identified mechanisms of inactivation of tumor suppressors, is found only in the minority of sporadic non-cultured ...
Sarah M, Planchon +2 more
openaire +2 more sources
Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]
, 2008 To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Chan, W-C. +11 more
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Table_1_TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro.docx
, 2023 Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources.
N. U. Farrukh Hameed (10001728) +15 more
core +1 more source