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Prognostic value of angiogenic markers of endometrial cancer (literature review)
Сибирский онкологический журнал, 2022 Endometrial cancer is the most common cancer of the female reproductive organs. The purpose of the study was to summarize the available data on the role of angiogenic markers in the development, progression and prognosis of endometrial cancer.
N. S. Zolotukhina, L. F. Gulyaeva
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Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer [PDF]
Middle East Journal of Cancer, 2022 Background: Programmed death- ligand 1(PD-L1) acts as an immune checkpoint inhibitor. Phosphatase and tensin homolog (PTEN) is a somatically mutated tumor suppressor gene in numerous types of human cancer. The current study aimed to assess the prognostic
Noha Elaidy +3 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 Within the last few years, the lipid phosphatase PTEN has gained increasing attention.1 Initially described as a tumor suppressor gene, the function of PTEN meanwhile ranges from the regulation of the immune system to the recently established important function in neuronal growth.1,2⇓ On a cellular level, PTEN interferes with cell proliferation ...
Stefanie, Dimmeler, Andreas M, Zeiher
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PTEN regulation by Akt–EGR1–ARF–PTEN axis [PDF]
The EMBO Journal, 2008 The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes. Here, we describe a novel Akt-EGR1-alternate reading frame (ARF)-PTEN axis, in which PTEN activation in vivo requires p14ARF-mediated sumoylation of ...
Jianxiu, Yu +11 more
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Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. [PDF]
, 2011 Pluripotent stem cells (PSCs) hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal and potential to differentiate into every cell type in the body. One major barrier to the use of PSCs is their potential risk
Banerjee, Utpal +8 more
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SnapShot: PTEN Signaling Pathways [PDF]
Cell, 2008 is causative for familial diseases including Cowden syndrome, which is characterized by multiple hamartomas, developmental defects, and increased cancer susceptibility.The major tumor-suppressive activity of PTEN is attributed to its ability to hydrolyze the 3′ phosphate of phosphoinositides at the plasma membrane and thereby negatively regulate ...
Carracedo A +2 more
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Case Reports in Oncology, 2020 Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment.
Jamie A. Kmak +8 more
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Focus on PTEN regulation [PDF]
Frontiers in Oncology, 2015 The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P3, the phospholipid product of the class I PI3Ks. Besides its traditional role as a lipid phosphatase at the plasma membrane, a wealth of data has shown that PTEN can function ...
Bermúdez Brito, Miriam +2 more
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Indian Journal of Pathology and Microbiology, 2023 Objective: This article aims to study the effect of phosphate and tension homolog deleted on chromosome ten (PTEN) knockdown on colon cancer progression and macrophage polarization in the cancer environment.
Xu Han +4 more
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Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition [PDF]
, 2011 Overcoming de novo and acquired resistance to anticancer drugs that target signaling networks is a formidable challenge for drug design and effective cancer therapy.
Bown, James L. +5 more
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