Results 21 to 30 of about 164,611 (306)

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes [PDF]

, 2009
In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)-mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription factors, and also controls T ...
Feijoo, C., Sinclair, L.V., Sinclair, Linda V., David K. Finlay, Waugh, C.M., Hagenbeek, Thijs J., Doreen A. Cantrell, Cantrell, Doreen A., Waugh, Caryll M., Hagenbeek, T.J., Carmen Feijoo, Cantrell, D.A., Feijoo, Carmen, Finlay, D.K., Hergen Spits, Spits, Hergen, Spits, H., Linda V. Sinclair, Finlay, David K., Caryll M. Waugh, Thijs J. Hagenbeek   +20 more
core   +1 more source

The role of systemically perturbed PTEN and PKBß/AKT2 signaling in accumulation of hepatic lipids [PDF]

, 2013
Non-alcoholic fatty liver disease (NAFLD) is a major health problem and occurs frequently in the context of obesity and type 2 diabetes mellitus (T2D).
Schultze, Simon Manuel
core   +1 more source

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde, Wade Bushman, Travis J. Jerde, Zhong Wu, Dan Theodorescu   +4 more
core   +1 more source

PTEN at a glance

Journal of Cell Science, 2012
Since its discovery in 1997 ([Li and Sun, 1997][1]; [Li et al., 1997][2]; [Steck et al., 1997][3]), the phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5) P 3] phosphatase and tensin homolog (PTEN) has been established as one of the most frequently mutated tumor suppressor genes in ...
Yuji, Shi, Benjamin E, Paluch, Xinjiang, Wang, Xuejun, Jiang   +3 more
openaire   +3 more sources

Phosphorylation of the actin binding protein Drebrin at S647 and is regulated by neuronal activity and PTEN [PDF]

, 2013
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin ...
Rita Hendricusdottir, Louise Kay, Harwood, Adrian, Ismini E Papageorgiou, Britta J Eickholt, Harwood, Adrian John, Leslie, Nicholas R; id_orcid, van Diepen, Michael, Leslie, Nicholas R, Parsons, Madeline; id_orcid, Kreis, Patricia, Leslie, Nicholas R., Nicholas R Leslie, Kann, Oliver, Michiel van Diepen, Papageorgiou, Ismini E, Adrian Harwood, Patricia Kreis, Parsons, Maddy, Till Mack, Fox, Michael A., Kay, Louise, van Diepen, Michiel, Oliver Kann, Mack, Till, Papageorgiou, Ismini E., Hendricusdottir, Rita, Maddy Parsons, Ryves, Jonny, Jonny Ryves, Eickholt, Britta J., Eickholt, Britta J, Leslie Nicholas R., Papageorgiou Ismini E., Ryves Jonny, van Diepen Michiel, Hendricusdottir Rita, Mack Till, Kay Louise, Parsons Maddy, Harwood Adrian, Eickholt Britta J., Kann Oliver, Kreis Patricia   +43 more
core   +1 more source

Prognostic value of angiogenic markers of endometrial cancer (literature review)

Сибирский онкологический журнал, 2022
Endometrial cancer is the most common cancer of the female reproductive organs. The purpose of the study was to summarize the available data on the role of angiogenic markers in the development, progression and prognosis of endometrial cancer.
N. S. Zolotukhina, L. F. Gulyaeva
doaj   +1 more source

Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer [PDF]

Middle East Journal of Cancer, 2022
Background: Programmed death- ligand 1(PD-L1) acts as an immune checkpoint inhibitor. Phosphatase and tensin homolog (PTEN) is a somatically mutated tumor suppressor gene in numerous types of human cancer. The current study aimed to assess the prognostic
Noha Elaidy, Eman Abdelbary, Mohamed Hegazy, Amira Elwan   +3 more
doaj   +1 more source

Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. [PDF]

, 2012
We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice) characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein ...
Hammon Harald M., Bidlingmaier, Martin, Bernhard G Baumgartner, Andreas Hoeflich, Zeissler, Anja, Brenig Bertram, Binder Gerhard, Sawitzky, Mandy, Christ Bruno, Binder, Gerhard, Bidlingmaier Martin, Stock Peggy, Metzger, Friedrich, Christ, Bruno, Bertram Brenig, Renne Ulla, Bielohuby Maximilian, Cornelia C Metges, Zeissler Anja, Sawitzky Mandy, Barbara J M Stoehr, Hoeflich Andreas, Metges, Cornelia C., Solvig Görs, Anja Zeissler, Gerhard Binder, Brenig, Bertram, Stoehr, Barbara J. M., Fromm-Dornieden Carolin, Görs, Solvig, Bielohuby, Maximilian, Stock, Peggy, Hammon, Harald M., Hoeflich, Andreas, Stoehr Barbara J. M., Harald M Hammon, Fromm-Dornieden, Carolin, Friedrich Metzger, Langhammer, Martina, Martina Langhammer, Metges Cornelia C., Langhammer Martina, Martin Bidlingmaier, Renne, Ulla, Görs Solvig, Mandy Sawitzky, Peggy Stock, Maximilian Bielohuby, Baumgartner, Bernhard G., Ulla Renne, Carolin Fromm-Dornieden, Baumgartner Bernhard G., Bruno Christ, Metzger Friedrich   +53 more
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p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex [PDF]

Molecular and Cellular Biology, 2009
The lipid phosphatase PTEN functions as a tumor suppressor by dephosphorylating the D3 position of phosphoinositide-3,4,5-trisphosphate, thereby negatively regulating the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway. In mammalian cells, PTEN exists either as a monomer or as a part of a >600-kDa complex (the PTEN-associated complex [PAC ...
Rosalia, Rabinovsky, Panisa, Pochanard, Chontelle, McNear, Saskia M, Brachmann, Jonathan S, Duke-Cohan, Levi A, Garraway, William R, Sellers   +6 more
openaire   +2 more sources

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C., Sutherland, C., Sutherland, Calum, Gallagher, J., Miller, Lisa C., Ashford, M.L.J., Ning, K., Laidlaw, Hilary A., Watterson, Kenneth R., Sutherland, Calum; id_orcid, Laidlaw, H.A., Ning, Ke, Ashford, Michael L. J.; id_orcid, Watterson, K.R., Gallagher, Jennifer, Ashford, Michael L.J.   +15 more
core   +1 more source