Results 21 to 30 of about 147,647 (257)

Table_1_TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro.docx

, 2023
Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources.
N. U. Farrukh Hameed (10001728), Chowdari V. Kodavali (17120998), Apeng Chen (4491871), Nduka Amankulor (3042363), Jing Wang (6206297), Mamindla Priyadarshini (17120995), Sanjay K. Singh (139851), Yan Wang (15435), Gregory N. Fuller (13907545), Ahmed Habib (17120992), Baoli Hu (7216646), Scott M. Kulich (17121001), Rivka R. Colen (8745864), Wencai Ma (792123), Pascal O. Zinn (15012168), Lincoln A. Edwards (6237734)   +15 more
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Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease

, 2023
Heterozygous germline mutations in PTEN gene predispose to hamartomas and tumors in different tissues, as well as to neurodevelopmental disorders, and define at genetic level the PTEN Hamartoma Tumor Syndrome (PHTS).
Sandra Luna, Luna, Sandra, Torices, Leire, Isabel Rodríguez-Escudero, Leire Torices, Fernández-Acero Bascones, Teresa, Rafael Pulido, Urioste, Miguel, Mingo, Janire, José I. López, Nunes-Xavier, Caroline E., Molina Martín, María, Jiménez Cid, Víctor, María Currás, Pulido, Rafael, Teresa Fernández-Acero, López, José I., Caroline E. Nunes-Xavier, Rodríguez Escudero, María Isabel, María Molina, Miguel Urioste, Fátima Mercadillo, Currás, María, Janire Mingo, Mercadillo, Fátima, Víctor J. Cid   +25 more
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PTEN, here, there, everywhere [PDF]

Cell Death & Differentiation, 2013
Loss of function of the phosphatase and tensin homolog (PTEN) tumor suppressor is frequently found in many human malignancies.1 PTEN antagonizes the phosphatidylinositide 3-kinase (PI3K) pathway2 by dephosphorylating the 3′ position of phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] (or PIP3).2, 3 PIP3 serves as a second messenger whose ...
C, Bassi, V, Stambolic
openaire   +2 more sources

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer [PDF]

, 2008
Ovarian cancer is the most frequent cause of death from gynaecological cancer in the Western world. Current prognostic factors do not allow reliable prediction of response to chemotherapy and survival for individual ovarian cancer patients.
de Bock, G. H., A P G Crijns, Hollema, H., P de Graeff, de Bock, G.H.; id_orcid, de Vries, E.G.; id_orcid, Crijns, A.P.G., G H de Bock, de Bock, G.H., A G J van der Zee, Bartlett, J.M., H G Klip, S de Jong, de Graeff, P., J M Bartlett, van der Zee, A. G. J., Crijns, A. P. G., ten Hoor, K.A., de Vries, E.G.E., van der Zee, A.G.J., Wisman, G.B., ten Hoor, K. A., de Vries, E. G. E., Bartlett, J. M., H Hollema, K A ten Hoor, Klip, H. G., G B A Wisman, de Jong, S., Wisman, G. B. A., Klip, H.G., van der Zee, A.G., de Jong, S.; id_orcid, Crijns, A.P., K Oien, Oien, K., Wisman, G.B.A., de Vries, E.G., E G E de Vries   +38 more
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A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons

, 2021
The PTEN tumor suppressor gene is mutated with high incidence in tumors and in thegermline of patients with cancer predisposition or with macrocephaly associatedwith autism.PTENnonsense mutations generating premature termination codons (PTC)and producing
Molina Martín, María, Jiménez Cid, Víctor, Luna, Sandra, Torices, Leire, Pulido, Rafael, Amo, Laura, López, José I., Cortés, Jesús M., Rodríguez Escudero, María Isabel, Erramuzpe, Asier, Ruiz‐Ibarlucea, Pablo, Tejada, María I., Nunes‐Xavier, Caroline E., Mingo, Janire   +13 more
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Genotype-phenotype associations in a large PTEN Hamartoma Tumor Syndrome (PHTS) patient cohort [PDF]

, 2022
Funding Information: This work (L.A.J.H. and J.R.V.) was financially supported by the PTEN Research Foundation . E.R.W. and D.G.E. are supported by the NIHR Manchester Biomedical Research Centre (Grant Reference Number 1215–200074 ). E.T. is supported by
Irmejs, Arvīds, Aretz, Stefan, Vos, Janet R, PTEN Study Group, Venselaar, Hanka, Hendricks, Linda A.J, Hoogerbrugge, Nicoline   +6 more
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PTEN and Gynecological Cancers [PDF]

Cancers, 2019
PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. It is involved in a great variety of biological processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism.
Camilla Nero, Francesca Ciccarone, Antonella Pietragalla, Giovanni Scambia   +3 more
openaire   +2 more sources

Phosphorylation of the actin binding protein Drebrin at S647 and is regulated by neuronal activity and PTEN

, 2013
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin ...
Rita Hendricusdottir, Louise Kay, Harwood, Adrian, Ismini E Papageorgiou, Britta J Eickholt, Harwood, Adrian John, Leslie, Nicholas R; id_orcid, van Diepen, Michael, Leslie, Nicholas R, Parsons, Madeline; id_orcid, Kreis, Patricia, Leslie, Nicholas R., Nicholas R Leslie, Kann, Oliver, Michiel van Diepen, Papageorgiou, Ismini E, Adrian Harwood, Patricia Kreis, Parsons, Maddy, Till Mack, Fox, Michael A., Kay, Louise, van Diepen, Michiel, Oliver Kann, Mack, Till, Papageorgiou, Ismini E., Hendricusdottir, Rita, Maddy Parsons, Ryves, Jonny, Jonny Ryves, Eickholt, Britta J., Eickholt, Britta J   +31 more
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Protein kinase B : the beta version elucidating novel contributions of protein kinase B beta (PKBß/Akt2) to endocrine metabolism, PCOS and cancer [PDF]

, 2012
Protein kinase B (PKB/Akt) is a serine/threonine protein kinase that mediates signaling crucial for normal cellular metabolism, proliferation, survival, and differentiation.
Restuccia, David
core   +1 more source

PTEN-uating Restenosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Within the last few years, the lipid phosphatase PTEN has gained increasing attention.1 Initially described as a tumor suppressor gene, the function of PTEN meanwhile ranges from the regulation of the immune system to the recently established important function in neuronal growth.1,2⇓ On a cellular level, PTEN interferes with cell proliferation ...
Stefanie, Dimmeler, Andreas M, Zeiher
openaire   +2 more sources