Results 21 to 30 of about 223,608 (200)
Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]
, 2016 In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay +7 more
core +3 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 Within the last few years, the lipid phosphatase PTEN has gained increasing attention.1 Initially described as a tumor suppressor gene, the function of PTEN meanwhile ranges from the regulation of the immune system to the recently established important function in neuronal growth.1,2⇓ On a cellular level, PTEN interferes with cell proliferation ...
Stefanie, Dimmeler, Andreas M, Zeiher
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Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]
, 2020 Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak +4 more
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PTEN regulation by Akt–EGR1–ARF–PTEN axis [PDF]
The EMBO Journal, 2008 The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes. Here, we describe a novel Akt-EGR1-alternate reading frame (ARF)-PTEN axis, in which PTEN activation in vivo requires p14ARF-mediated sumoylation of ...
Jianxiu, Yu +11 more
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Case Reports in Oncology, 2020 Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment.
Jamie A. Kmak +8 more
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2023 Objective: This article aims to study the effect of phosphate and tension homolog deleted on chromosome ten (PTEN) knockdown on colon cancer progression and macrophage polarization in the cancer environment.
Xu Han +4 more
doaj +1 more source
SnapShot: PTEN Signaling Pathways [PDF]
Cell, 2008 is causative for familial diseases including Cowden syndrome, which is characterized by multiple hamartomas, developmental defects, and increased cancer susceptibility.The major tumor-suppressive activity of PTEN is attributed to its ability to hydrolyze the 3′ phosphate of phosphoinositides at the plasma membrane and thereby negatively regulate ...
Carracedo A +2 more
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Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]
, 2010 Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Dan Theodorescu +3 more
core +2 more sources
Focus on PTEN regulation [PDF]
Frontiers in Oncology, 2015 The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P3, the phospholipid product of the class I PI3Ks. Besides its traditional role as a lipid phosphatase at the plasma membrane, a wealth of data has shown that PTEN can function ...
Bermúdez Brito, Miriam +2 more
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Cells, 2020 The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to ...
Tsung-Lin Lee +6 more
doaj +1 more source