Understanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator
Cells, 2022 The parathyroid hormone type 1 receptor (PTH1R) acts as a canonical class B G protein-coupled receptor, regulating crucial functions including calcium homeostasis and bone formation.
Mengrong Li +5 more
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Identification of a novel PTH1R variant in a family with primary failure of eruption
BMC Oral Health, 2023 Background Primary failure of tooth eruption (PFE) is a rare autosome genetic disorder that causes open bite. This work aimed to report a small family of PFE(OMIM: # 125,350) with a novel PTH1R variant.
Yunchen Zha +5 more
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PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway [PDF]
Frontiers in Endocrinology, 2022 After the initial signaling action of parathyroid hormone (PTH) on bone was shown to be activation of adenylyl cyclase, its target was found to be cells of the osteoblast lineage, to the exclusion of osteoclasts and their precursors. This led to the view
T. John Martin
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Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome
Communications Biology, 2023 The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that plays key roles in regulating calcium homeostasis and skeletal development via binding the ligands, PTH and PTH-related protein (PTHrP), respectively.
Ignacio Portales-Castillo +8 more
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Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice [PDF]
Signal Transduction and Targeted Therapy, 2020 In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood.
Xuekun Fu +17 more
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Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation
Nature Communications, 2022 Here the authors report two structures of human PTH1R-Gs complex bound to ligands PTH and ABL, providing insight into the molecular mechanism of ligand duration.
Xiuwen Zhai +10 more
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The role of Pth1r in posterior cranium cartilage regulation and craniosynostosis
Nature CommunicationsCraniosynostosis is a major craniofacial congenital disorder that causes developmental complications. During normal cranial development, intramembranous ossification forms the flat bones and sutures, while cartilage appears transiently in the posterior ...
Katsuhiko Amano +5 more
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Functional modulation of PTH1R activation and signalling by RAMP2 [PDF]
Proceedings of the National Academy of Sciences, 2021 Abstract Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate with different G protein-coupled receptors (GPCRs) including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulator of mineral ion homeostasis and bone metabolism.
Katarina Nemec +7 more
openaire +3 more sources
PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling. [PDF]
PLoS ONE, 2016 Primary failure of tooth eruption (PFE) is causally linked to heterozygous mutations of the parathyroid hormone receptor (PTH1R) gene. The mutants described so far lead to exchange of amino acids or truncation of the protein that may result in structural
Hariharan Subramanian +9 more
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eLife, 2023 Conditional deletion of the PTH1R in mesenchymal progenitors reduces osteoblast differentiation, enhances marrow adipogenesis, and increases zinc finger protein 467 (Zfp467) expression.
Hanghang Liu +8 more
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