Results 21 to 30 of about 2,933 (162)

Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor

Frontiers in Endocrinology, 2022
Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding.
Christoph Klenk, Leif Hommers, Leif Hommers, Leif Hommers, Martin J. Lohse, Martin J. Lohse, Martin J. Lohse, Martin J. Lohse   +7 more
doaj   +1 more source

Activity of Parathyroid Hormone Receptor Genes in Ligamentum Flavum Biopsies of Patients with Spinal Canal and Dural Sac Stenosis at the Lumbar Level

Acta Biomedica Scientifica, 2021
Parathyroid hormone receptors PTH1R and PTH2R are poorly studied in the pathology of the vertebral column and may be involved in both ectopic ossification of the vertebral ligaments and fibrous growth of the extracellular matrix, as well as in other ...
L. V. Rodionova, L. G. Samoilova, V. A. Sorokovikov   +2 more
doaj   +1 more source

PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. [PDF]

PLoS ONE, 2012
The molecular pathways by which long chain polyunsaturated fatty acids (LCPUFA) influence skeletal health remain elusive. Both LCPUFA and parathyroid hormone type 1 receptor (PTH1R) are known to be involved in bone metabolism while any direct link ...
Jose Candelario, Hesam Tavakoli, Mirianas Chachisvilis   +2 more
doaj   +1 more source

Type 1 Parathyroid Hormone Receptor (PTH1R) Nuclear Trafficking: Association of PTH1R with Importin α₁and β [PDF]

Endocrinology, 2006
Previous studies have shown that the type 1 PTH receptor (PTH1R), a class B G protein-coupled receptor, appears in the nucleus of target cells. Through immunofluorescence and deconvolution microscopy, we demonstrate that PTH1R, importin alpha(1), and importin beta are present within the nucleus and cytoplasm of osteoblast-like cell lines with the ...
Bryce W, Pickard, Anthony B, Hodsman, Laurence J, Fraher, Patricia H, Watson   +3 more
openaire   +2 more sources

Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

Frontiers in Cell and Developmental Biology, 2021
Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) are two peptides that regulate mineral ion homeostasis, skeletal development, and bone turnover by activating parathyroid hormone 1 receptor (PTH1R). PTH1R signaling is of profound
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan   +7 more
doaj   +1 more source

Identification of six novel PTH1R mutations in families with a history of primary failure of tooth eruption. [PDF]

PLoS ONE, 2013
Primary Failure of tooth Eruption (PFE) is a non-syndromic disorder which can be caused by mutations in the parathyroid hormone receptor 1 gene (PTH1R). Traditionally, the disorder has been identified clinically based on post-emergent failure of eruption
Lotte Risom, Line Christoffersen, Jette Daugaard-Jensen, Hanne Dahlgaard Hove, Henriette Skovgaard Andersen, Brage Storstein Andresen, Sven Kreiborg, Morten Duno   +7 more
doaj   +1 more source

Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival

BMC Cancer, 2022
Background Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer.
Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Libero Lauriola, Franco Oreste Ranelletti   +9 more
doaj   +1 more source

Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response

EBioMedicine, 2016
Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic response).
Lei Xiong, Wen-Fang Xia, Fu-Lei Tang, Jin-Xiu Pan, Lin Mei, Wen-Cheng Xiong   +5 more
doaj   +1 more source

Substantially Delayed Maturation of Growth Plate Chondrocytes in “Humanized” PTH1R Mice with the H223R Mutation of Jansen's Disease

JBMR Plus, 2023
Activating parathyroid hormone (PTH)/PTH‐related Peptide (PTHrP) receptor (PTH1R) mutations causes Jansen's metaphyseal chondrodysplasia (JMC), a rare disease characterized by growth plate abnormalities, short stature, and PTH‐independent hypercalcemia ...
Monica Reyes, Damla Firat, Patrick Hanna, Mohd Khan, Michael Bruce, Maria Shvedova, Tatsuya Kobayashi, Ernestina Schipani, Thomas J. Gardella, Harald Jüppner   +9 more
doaj   +1 more source

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH

JBMR Plus, 2021
Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism.
Tadatoshi Sato, Shiv Verma, Ashok Khatri, Thomas Dean, Olga Goransson, Thomas J Gardella, Marc N Wein   +6 more
doaj   +1 more source