Results 51 to 60 of about 2,933 (162)

Acute salinity and temperature challenges during early development of zebrafish: Differential gene expression of PTHs, PTHrPs and their receptors

Aquaculture and Fisheries, 2017
Parathyroid hormone (pth), parathyroid hormone-related peptide (pthrp) and their receptors are involved in the regulation of calcium homeostasis in all vertebrates.
Yingying Jin, Zhaohui Lan, Gege Zhu, Weiqun Lu   +3 more
doaj   +1 more source

Primary failure of tooth eruption: Etiology and management

Japanese Dental Science Review, 2022
Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R).
Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Tatsuo Shirota, Yoichi Miyamoto, Wanida Ono, Noriaki Ono   +5 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin, Lei Dong, Wang Kai, Ziyang Yu, Guoyong Yu, Weifeng Liu   +5 more
wiley   +1 more source

Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis

Journal of Orthopaedic Surgery and Research, 2010
Background To evaluate the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes from hyaline cartilage over the course of osteoarthritis (OA).
Skwara Adrian, Ostermeier Sven, Ronstedt Philipp, Szuwart Thomas, Becher Christoph, Fuchs-Winkelmann Susanne, Tibesku Carsten O   +6 more
doaj   +1 more source

Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice

JCI Insight, 2023
Bone metastases are a common complication of breast cancer. We have demonstrated that intermittent administration of parathyroid hormone (PTH[1-34]) reduces the incidence of bone metastases in murine models of breast cancer by acting on osteoblasts to ...
Srilatha Swami, Hui Zhu, Aria Nisco, Takaharu Kimura, Matthew J. Kim, Vaisakh Nair, Joy Y. Wu   +6 more
doaj   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, Volume 13, Issue 8, 9 February 2026.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Discovery of antibodies against PTH1R, a class B GPCR: characterisation of their binding and impact on PTH1R function

, 2018
Parathyroid hormone receptor 1 (PTH1R) belongs to the Secretin or Class B family of the G-protein coupled receptor (GPCR) superfamily and natively binds parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP). Ligand binding to PTH1R is a two-step process, which first involves binding to a large extracellular domain (ECD) and then to ...
openaire   +2 more sources

Senescent Cells Involved in Deterioration of Bone Microstructure by High‐Frequency Parathyroid Hormone 1–34 Administration and Bone Loss

Aging Cell, Volume 25, Issue 1, January 2026.
Senescent osteoblasts induced by PTH contribute to cortical bone loss in aged mice. Senolytic co‐treatment reduces senescence and prevents bone loss after PTH withdrawal, enhancing the durability of osteoporosis therapy. ABSTRACT Osteoporosis is characterized by reduced bone mass and structural deterioration, leading to increased fracture risk ...
Masayuki Bun, Yuichiro Ukon, Masato Ikuta, Takayuki Kitahara, Takuya Furuichi, Hiromasa Hirai, Daisuke Tateiwa, Yuya Kanie, Masayuki Furuya, Takahito Fujimori, Satoru Otsuru, Seiji Okada, Takashi Kaito   +12 more
wiley   +1 more source

Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling

JCI Insight
Regeneration of orofacial bone defects caused by inflammation-related diseases or trauma remains an unmet challenge. Parathyroid hormone 1 receptor (PTH1R) signaling is a key mediator of bone remodeling whereas the regulatory mechanisms of PTH1R ...
Yi Fan, Ping Lyu, Jiahe Wang, Yali Wei, Zucen Li, Shiwen Zhang, Takehito Ouchi, Junjun Jing, Quan Yuan, Clifford J. Rosen, Chenchen Zhou   +10 more
doaj   +1 more source