Results 71 to 80 of about 2,933 (162)

Mandibular Condylar Cartilage in Development and Diseases: A PTHrP‐Centric View

Orthodontics &Craniofacial Research, Volume 28, Issue S1, Page S70-S80, December 2025.
ABSTRACT The mandibular condylar cartilage (MCC) is a dual‐function component of the temporomandibular joint (TMJ), acting as both articular cartilage for jaw movement and growth cartilage for vertical growth of the mandibular condyle. Parathyroid hormone‐related protein (PTHrP) plays a critical role in orchestrating chondrogenesis in the long bone ...
Chiaki Tsutsumi‐Arai, Amy Tran, Yuki Arai, Wanida Ono, Noriaki Ono   +4 more
wiley   +1 more source

SUN-747 PTH1R Mosaicism In Jansen Metaphyseal Chondrodysplasia

Journal of the Endocrine Society
Abstract Disclosure: W. Abbas: None. C.R. Ferreira: None. N. Balatska: None. G. Grigelioniene: None. K. Baltzer Sollander: None. L. Bliss: None. M. Motevalli: None. H. Jüppner: None. A.M. Boyce: None. S. Jha: None. Background: Jansen Metaphyseal Chondrodysplasia (JMC) is an ultra-rare skeletal dysplasia caused by ...
Abbas, Wafa, Ferreira, Carlos R, Balatska, Nataliya, Grigelioniene, Giedre, Sollander, Karin Baltzer, Bliss, Lynn, Motevalli, Mahsa, Jüppner, Harald, Boyce, Alison M, Jha, Smita   +9 more
openaire   +1 more source

Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH1R expression

Molecular Oncology, 2019
We have previously reported the expression of parathyroid hormone‐like hormone (PTHLH) in well‐differentiated, Schwannian stroma‐rich neuroblastic tumors.
Marta García, Carlos Javier Rodríguez‐Hernández, Silvia Mateo‐Lozano, Sara Pérez‐Jaume, Eliana Gonçalves‐Alves, Cinzia Lavarino, Jaume Mora, Carmen deTorres   +7 more
doaj   +1 more source

Single‐cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood–brain–tumor barrier and tumor progression

MedComm
The blood–brain barrier is often altered in glioblastoma (GBM) creating a blood–brain–tumor barrier (BBTB) composed of pericytes. The BBTB affects chemotherapy efficacy. However, the expression signatures of BBTB‐associated pericytes remain unclear.
Yuzhe Li, Changwu Wu, Xinmiao Long, Xiangyu Wang, Wei Gao, Kun Deng, Bo Xie, Sen Zhang, Minghua Wu, Qing Liu   +9 more
doaj   +1 more source

Identification of a Novel PTH1R Mutation in Primary Failure of Eruption: A Case Report and Therapeutic Perspectives

Journal of Indian Academy of Oral Medicine and Radiology
Primary failure of eruption (PFE) is an uncommon genetic disorder where non-ankylosed teeth do not emerge in the mouth despite the presence of an unobstructed eruption pathway. It is essential to consider differential diagnoses like mechanical failure of
Sivani Darjee, Adit Srivastava, Saumya Shukla, Amlendu Shekhar   +3 more
doaj   +1 more source

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +1 more source

Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone–GPCR–arrestin complex

Nature Communications
The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling.
Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga   +6 more
doaj   +1 more source

PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases

International Journal of Endocrinology, 2018
Metastatic breast cancer (BrCa) is currently incurable despite great improvements in treatment of primary BrCa. The incidence of skeletal metastases in advanced BrCa occurs up to 70%.
Yanmei Yang, Bin Wang
doaj   +1 more source

Selection of an artificial binding protein against the ectodomain of PTH1R

, 2013
In this thesis, a naive scaffold library, based on human γB crystallin (hγBC), was selected against the N-terminal extracellular domain of parathyroid hormone 1 receptor (nPTH1R), a class B GPCR. Four rounds of a biopanning process were performed and one hγBC binding variant, called 2G4, was repeatedly isolated.
openaire   +2 more sources

Mapping the global landscape of PTH1R agonists in osteoporosis: a bibliometric analysis

Abstract PTH1R agonists are cornerstone osteoanabolic therapies for osteoporosis, yet the intellectual structure and pharmacological evolution of this field have not been systematically characterized. In this bibliometric analysis, publications on PTH1R agonists in osteoporosis from 2001 to 2025 were retrieved from the Web of Science ...
Yongchao Huang, Xin Zhang, Shengtao Wang, Yuhan Sui, Xinni Yang, Jun Liu, Hong Liu, Zhaoxu Li   +7 more
openaire   +1 more source