Results 131 to 140 of about 3,009 (161)

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes

Immunogenetics, 2011
The Wellcome Trust Case Control Consortium (WTCCC) genome-wide study found association of PTPN2 with three autoimmune diseases, among them is type 1 diabetes (T1D). This result was confirmed by a follow-up study that pointed to new independent signals within the region. However, both studies were performed in patients with an early-onset T1D.
Elena Urcelay, Laura Espino-Paisán, MIGUEL Fernandez-Arquero   +2 more
exaly   +3 more sources

Characterization of PTPN2 and its use as a biomarker

Methods, 2014
For years, the two main isoforms of PTPN2 have been an interesting yet academic topic of debate for researchers working on this phosphatase. In recent years, several studies were published in which these isoforms were attributed specific functions. Most importantly, differences in their stoichiometry have been reported to be associated with certain ...
Stéphanie, Bussières-Marmen, Andrew P, Hutchins, Anja, Schirbel, Nancy, Rebert, Tony, Tiganis, Claudio, Fiocchi, Diego, Miranda-Saavedra, Michel L, Tremblay   +7 more
openaire   +3 more sources

Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader

Journal of Medicinal Chemistry, 2023
Protein tyrosine phosphatase nonreceptor Type 2 (PTPN2) is an attractive target for cancer immunotherapy. PTPN2 and another subtype of PTP1B are highly similar in structure, but their biological functions are distinct. Therefore, subtype-selective targeting of PTPN2 remains a challenge for researchers.
Linghao Hu, Huiyun Li, Junlin Qin, Dan Yang, Jieming Liu, Xiaomin Luo, Jingkun Ma, Cheng Luo, Fei Ye, Yubo Zhou, Jia Li, Mingliang Wang   +11 more
openaire   +2 more sources

570 In Vivo PTPN2-Deficiency and a Dominant-Negative PTPN2 Mutation Cause Increased Intestinal Permeability and Alter Tight Junction Composition

Gastroenterology, 2014
We have previously generated C57BL/6J-Tg(Car1-cre)5Flt transgenic mice (CAC) with large intestine, epithelial cell-specific expression of Cre recombinase and demonstrated that they can be used to study colorectal cancer. Here we report a novel observation with CAC mice that expands their utility as an experimental model for colitis and inflammation ...
Ronald R. Marchelletta, Young Su Park, Lucas Bernts, Stephan Myers, Taylaur Smith, Moorthy Krishnan, Kim E. Barrett, Declan F. McCole   +7 more
openaire   +1 more source

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma

Journal of Medicinal Chemistry
The global incidence of melanoma has risen substantially over the past two decades, driving an urgent need for novel therapeutic strategies. The nonreceptor protein tyrosine phosphatases PTPN2/PTPN1 have emerged as promising therapeutic targets, yet developing effective inhibitors faces significant drug-like property challenges.
Dawei Wang, Mingge Song, Chen Tong, Wenmu Wang, Qiannan Li, Jianing Liu, Anyan Chen, Ya Chen, Liping Wang, Haiping Hao, Xiao Wang, Kailin Han, Yibei Xiao, Wenbin Kuang, Peng Yang   +14 more
openaire   +2 more sources

PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3

Cell Biochemistry and Function
AbstractPsoriasis is a recurrent and protracted disease that severely impacts the patient's physical and mental health. Thus, there is an urgent need to explore its pathogenesis to identify therapeutic targets. The expression level of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) was analyzed by immunohistochemistry techniques in psoriatic ...
Shougang Liu, Fanghua Liu, Zeqiao Zhang, Zhe Zhuang, Yongfeng Chen   +4 more
openaire   +2 more sources

Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China

Gene, 2019
Psoriasis is a chronic immune-mediated disease with a complex etiology involving various genetic and immunological factors as well as environmental factors. Psoriasis is thought to be mediated by T-cells polarized to a Th17 fate. PTPN2 encodes the T-cell protein tyrosine phosphatase, which acts as a negative regulator of the JAK/STAT signaling pathways
Qingbu Mei, Chang Liu, Xuelong Zhang, Qiuyan Li, Xueyuan Jia, Jie Wu, Wenjing Sun, Yuandong Qiao, Jiawei Wu, Yuzhen Li, Jingcui Yu, Songbin Fu, Lidan Xu   +12 more
openaire   +2 more sources

PTPN2 acts as a tumor suppressor and therapeutic target in ovarian cancer

Biochemical and Biophysical Research Communications
Ovarian cancer (OC) remains the most lethal gynecological malignancy, with metastasis and chemoresistance driving poor outcomes. Non-receptor protein tyrosine phosphatase 2 (PTPN2) is a critical regulator of oncogenic signaling pathways, but its role in OC progression remains poorly understood.
Xiaoli Sun, Wenkai Zhang, Hongmei Wang, Junmei Hao, Wenning Shi, Ping Lei, Guangyu Wei, Yusheng Liu, Cong Xu, Lianqin Li, Liting Yu, Dao-Lai Zhang   +11 more
openaire   +2 more sources

Association of Non-coding SNPs in the Autoimmune Susceptibility Gene PTPN2 with Diminished PTPN2 Expression

Clinical Immunology, 2010
Karen Cerosaletti, S. Alice Long, Jhon-Chun Ho, Jia Yin Wan, Jane Buckner   +4 more
openaire   +1 more source

Discovery of HDM2010, a highly potent PTPN2 inhibitor for immunotherapy.

Journal of Clinical Oncology
e15021 Background: Protein tyrosine phosphatase non-receptor type 2 (PTPN2), a negative regulator of JAK–STAT pathways that plays a crucial role in the immune system, has been identified as a promising target for immunotherapy. Genetic deletion of PTPN2 in either tumor cells or host immune cells promotes the anti-tumor immunity.
Ke Li, Chen Min, Zhiping Zhang, Dongzhou Liu   +3 more
openaire   +1 more source