Results 171 to 180 of about 14,132 (182)

Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani

Protein Expression and Purification, 2004
Pteridine reductase 1 (PTR1) is part of a novel metabolic pathway in Leishmania associated with folate metabolism. Its main function is to salvage pterins but a second one is to reduce folates. The novelty and possible uniqueness of the pathway in which PTR1 is involved opens the possibility of developing specific inhibitors, which in combination with ...
Pranav, Kumar, Hema, Kothari, Neeloo, Singh   +2 more
openaire   +2 more sources

Identification of new potential inhibitors of pteridine reductase-1 (PTR1) via biophysical and biochemical mechanism-based approaches: Step towards the treatment of Leishmaniasis

International Journal of Biological Macromolecules
Leishmaniasis is a parasitic disease, which spreads from the bite of an infected Phlebotomine fly to human hosts. The disease is characterized by a number of clinical manifestations, such as ulcerative lesions at the site of sandfly bite (cutaneous form), inflammation of mucosal membranes (mucosal leishmaniasis) or the deadly visceral form.
Muhammad Yousuf, Humaira Zafar, null Atia-tul-Wahab, Sammer Yousuf, Noor Rahman, Salar Hafez Ghoran, Aftab Ahmed, M. Iqbal Choudhary   +7 more
openaire   +2 more sources

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

Molecular and biochemical parasitology, 1998
We have isolated the pteridine reductase-1 gene (ptr1), from Trypanosoma cruzi (Y strain), located contiguous to the Trypanosoma cruzi P-glycoprotein-2 (tcpgp2). The gene encodes a member of the family of short-chain dehydrogenases, enzymes that are involved in several oxidoreduction reactions. One member of the family, pteridine reductase-1 (PTR1) has
C, Robello, P, Navarro, S, Castanys, F, Gamarro   +3 more
openaire   +1 more source

Repurposing of approved drugs as candidates for the treatment of kala-azar: a computational study on Rab5a and PTR1 from Leishmania donovani as targets

2023
German Conference on Bioinformatics : 12-14 September, 2024, Hamburg, Germany.
Arsić, Biljana, Janjić, Jovana, Milićević, Jelena, Glišić, Sanja   +3 more
openaire   +1 more source

In silico analyses of sesquiterpene-related compounds against pteridine reductase (PTR1)

Planta Medica, 2014
FA Bernal, E Coy-Barrera
openaire   +1 more source

Ptr1 is a CC-NLR immune receptor that mediates recognition of diverse bacterial effectors in multiple solanaceous plants

Physiological and Molecular Plant Pathology, 2023
Benjamin J. Haefner, Tara H. McCrudden, Gregory B. Martin   +2 more
openaire   +1 more source

Trypanosoma brucei PTR1 in complex with inhibitor 10

, 2014
Stefano Mangani, F. Di Pisa, Cecilia Pozzi   +2 more
openalex   +1 more source

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-1,9-dihydro-6H-purine-6-thione (DX4)

, 2009
L.B. Tulloch, W.N. Hunter
openalex   +1 more source

Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor DX1

, 2007
L.B. Tulloch, W.N. Hunter
openalex   +1 more source

Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and substrate (folate)

, 2007
L.B. Tulloch, W.N. Hunter
openalex   +1 more source