Results 11 to 20 of about 3,370 (132)

Computational investigation of turmeric phytochemicals targeting PTR1 enzyme of Leishmania species [PDF]

Heliyon
Wasia Ullah, Wenfeng Wu, Nosheen Malak, Nasreen Nasreen, Ayman A. Swelum, Liliana Aguilar-Marcelino, Sadaf Niaz, Adil Khan, Mourad Ben Saïd, Chien‐Chin Chen   +9 more
openalex   +2 more sources

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Abedawn I. Khalaf, Addie M., Arcari J. T., Baker N., Barrett M. P., Barrett M. P., Bridges D. J., Brun R., Bursavich M. G., Carter N. S., Cavazzuti A., Colin J. Suckling, Colin L. Gibson, Creek D. J., Dawson A., Dincer S., Federica Giordani, Gangjee A., Gibson C. L., Gourley D. G., Judith K. Huggan, Kaspersen S. J., Keri L. Barrack, Kirsten Stewart, Le Brazidec J.-Y., Matovu E., Michael P. Barrett, Mohamed M. S., Mpamhanga C. P., Pui Ee Wong, Raz B., Sienkiewicz N., Simarro P. P., Spinks D., Tari L. W., Taylor E. C., Tessier P. R., Trzoss M., Tulloch L. B., William N. Hunter, Xie H., Zhu G.   +41 more
core   +4 more sources

Universal Compressed Text Indexing [PDF]

, 2018
The rise of repetitive datasets has lately generated a lot of interest in compressed self-indexes based on dictionary compression, a rich and heterogeneous family that exploits text repetitions in different ways. For each such compression scheme, several
Navarro, Gonzalo, Prezza, Nicola
core   +2 more sources

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity [PDF]

, 2017
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold.
Alcantara, Laura M, Behrens, Birte, Borsari, Chiara, Cordeiro-da-Silva, Anabela, Costi, Maria Paola, Dello Iacono, Lucia, Di Pisa, Flavio, Ferrari, Stefania, Fontana, Vanessa, Freitas-Junior, Lucio H, Gul, Sheraz, Kuzikov, Maria, Landi, Giacomo, Mangani, Stefano, Moraes, Carolina B, Poehner, Ina, Pozzi, Cecilia, Santarem, Nuno, Santucci, Matteo, Wade, Rebecca C   +19 more
core   +2 more sources

Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome [PDF]

, 2018
The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids.
Boesche, Markus, Drewes, Gerard, Fairlamb, Alan, Ghidelli-Disse, Sonja, Gilbert, Ian, Ong, Han, Thomas, Michael, Tinti, Michele, Urbaniak, Michael, Webster, Lauren, Wyllie, Susan   +10 more
core   +11 more sources

On the expressiveness and monitoring of metric temporal logic [PDF]

, 2019
It is known that Metric Temporal Logic (MTL) is strictly less expressive than the Monadic First-Order Logic of Order and Metric (FO[
Ho, H.M., Ouaknine, J, Worrell, J
core   +2 more sources

New Englanders, Out of Their Minds [PDF]

, 2016
By comparing The Witch (2016) to The Shining (Stanley Kubrick, 1980), I argue that Robert Eggers\u27 new film contests Perry Miller\u27s sympathetic reading of the Puritans offered as the formation of American Studies, returning us to the 19th century ...
Metz, Walter C
core   +2 more sources

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs [PDF]

, 2016
Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification ...
Anabela Cordeiro-da-Silva, Annalisa Tait, Bernhard Ellinger, Bifeld E., Birte Behrens, Catarina Baptista, Cecilia Pozzi, Chiara Borsari, Eugenia Bifeld, Federica Pellati, Flavio Di Pisa, Gesa Witt, Giacomo Landi, Ina Poehner, Jeanette Reinshagen, Joachim Clos, José M Alunda, Juan Torrado, Julia Eick, Luca Costantino, Lucia Dello Iacono, Manfred Kohler, Maria Kuzikov, Maria Paola Costi, Markus Wolf, María D. Jiménez-Antón, María J. Corral, Matteo Trande, Nuno Santarem, Oliver Keminer, Paloma Tejera Nevado, Philip Gribbon, Rebecca C. Wade, Rosaria Luciani, Sereno D., Sheraz Gul, Stefan Henrich, Stefania Ferrari, Stefano Mangani   +38 more
core   +30 more sources

Transcriptomic analysis of longitudinal Burkholderia pseudomallei infecting the cystic fibrosis lung [PDF]

, 2018
The melioidosis bacterium, Burkholderia pseudomallei, is increasingly being recognised as a pathogen in patients with cystic fibrosis (CF). We have recently catalogued genome-wide variation of paired, isogenic B.
Bell, Scott C., Currie, Bart J., Kidd, Timothy J., Price, Erin P., Sarovich, Derek S., Viberg, Linda T.   +5 more
core   +1 more source

Lynx: Using OS and hardware support for fast fine-grained inter-core communication [PDF]

, 2016
Designing high-performance software queues for fast intercore communication is challenging, but critical for maximising software parallelism. State-of-the-art single-producer / single-consumer queues for streaming applications contain multiple sections ...
Jones, TM, Mitropoulou, K, Porpodas, V, Zhang, X   +3 more
core   +2 more sources