The potential therapeutic role of PTR1 gene in non‐healing anthroponotic cutaneous leishmaniasis due to Leishmania tropica [PDF]
Journal of Clinical Laboratory Analysis, 2020 AbstractBackgroundDrug resistance is a common phenomenon frequently observed in countries where leishmaniasis is endemic. Due to the production of the pteridine reductase enzyme (PTR1), drugs lose their efficacy, and consequently, the patient becomes unresponsive to treatment. This study aimed to compare the in vitro effect of meglumine antimoniate (MA)
Monireh Sezavar +8 more
wiley +4 more sources
An exploration of potent antileishmanial agents derived from quinoline-thiazole and thiadiazole hybrids, targeting DHFR-TS and PTR1: design, synthesis, and computational analyses. [PDF]
RSC Med ChemNeglected tropical diseases (NTDs) encompass a broad spectrum of infectious diseases predominantly found in tropical and subtropical regions.
Rashdan HRM +10 more
europepmc +4 more sources
NbPTR1 confers resistance against Pseudomonas syringae pv. actinidiae in kiwifruit [PDF]
Plant, Cell & Environment, 2023 AbstractPseudomonas syringae pv. actinidiae biovar 3 (Psa3) causes a devastating canker disease in yellow‐fleshed kiwifruit (Actinidia chinensis). The effector HopZ5, which is present in all isolates of Psa3 causing global outbreaks of pandemic kiwifruit canker disease, triggers immunity in Nicotiana benthamiana and is not recognised in susceptible A ...
Shin‐Mei Yeh +10 more
wiley +4 more sources
Journal of Food Quality, 2022 Pistacia integerrima Stew ex Brandis is a valued medicinal plant used for curing various diseases such as diarrhea, fever, liver disorder, pain, asthma, and inflammation. The aim of this study was the isolation of bioactive leishmanicidal agents from the
Hassan A. Hemeg +8 more
doaj +2 more sources
Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors [PDF]
PharmaceuticalsBackground/Objectives: Pteridine reductase 1 (PTR1) has been one of the prime targets for discovering novel antileishmanial therapeutics in the fight against Leishmaniasis.
Moses N. Arthur +6 more
doaj +2 more sources
Evaluation of the Antileishmanial Activity of Some Benzimidazole Derivatives Using In Vitro and In Silico Techniques [PDF]
Veterinary SciencesBenzimidazole derivatives are well known for their anthelmintic activity. Investigating the potential efficacy of new derivatives of this class against various parasites is essential to identify novel drug candidates.
Mustafa Eser +4 more
doaj +2 more sources
Pteridine reductase (PTR1); dihydrofolate reductase (DHFR) [PDF]
Science-Business eXchange, 2008 openalex +2 more sources
Dihydrofolate reductase (DHFR); pteridine reductase (PTR1) [PDF]
Science-Business eXchange, 2012 openalex +2 more sources
Underpinning regions associated with nitrogen use efficiency in Brassica juncea L. Czern: using associative transcriptomics approach [PDF]
BMC Plant BiologyBackground Breeding crops for enhanced understanding of apparent nitrogen use efficiency (NUE) requires understanding of phenotypic variations and underlying genetics.
Akshita Awasthi +7 more
doaj +2 more sources
Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities [PDF]
, 2022 SUMMARYNucleotide-binding and leucine-rich repeat receptors (NLRs) detect pathogen effectors inside the plant cell. To identify Nicotiana benthamiana NLRs (NbNLRs) with novel effector recognition specificity, we designed an NbNLR VIGS library and conducted a rapid reverse genetic screen.
Ye Jin Ahn +12 more
openalex +2 more sources