Results 21 to 30 of about 14,132 (182)

Ptr1 evolved convergently with RPS2 and Mr5 to mediate recognition of AvrRpt2 in diverse solanaceous species [PDF]

The Plant Journal, 2020
SummaryThePtr1 (Pseudomonas tomato race 1)locus inSolanum lycopersicoidesconfers resistance to strains ofPseudomonas syringaepv. tomato expressing AvrRpt2 andRalstonia pseudosolanacearumexpressing RipBN. Here we describe the identification and phylogenetic analysis of thePtr1gene.
Carolina Mazo‐Molina, Samantha Mainiero, Benjamin J. Haefner, Ryland Bednarek, Jing Zhang, Ari Feder, Kai Shi, Susan R. Strickler, Gregory B. Martin   +8 more
  +6 more sources

Thiadiazine-thiones as inhibitors of leishmania pteridine reductase (PTR1) target: investigations and in silico approach

Journal of Biomolecular Structure and Dynamics, 2023
Leishmaniasis is a widespread parasitic disease and is one of the major public health concerns in developing countries. Many drugs have been identified for leishmania as targets, but the potential toxicity and long-term treatment remain the most significant problems in terms of further development.
Amneh Shtaiwi
openalex   +4 more sources

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities [PDF]

New Phytologist, 2023
Summary Some nucleotide‐binding and leucine‐rich repeat receptors (NLRs) indirectly detect pathogen effectors by monitoring their host targets.
Ye Jin Ahn, Haseong Kim, Sera Choi, Carolina Mazo‐Molina, Maxim Prokchorchik, Ning Zhang, B.-G. Kim, Hyunggon Mang, Naio Koehler, Jieun Kim, Soeui Lee, Hayeon Yoon, Doil Choi, Min‐Sung Kim, Cécile Segonzac, Gregory B. Martin, Alex Schultink, Kee Hoon Sohn   +17 more
openalex   +3 more sources

Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition

European Journal of Medicinal Chemistry, 2022
The leishmaniasis are a group of vector-borne diseases caused by a protozoan parasite from the genus Leishmania. In this study, a series of thiazolopyrimidine derivatives were designed and synthesized as novel antileishmanial agents with LmPTR1 inhibitory activity.
Hüseyin İstanbullu, Gülşah Bayraktar, Gülşah Karakaya, Hasan Akbaba, Nami Ege Perk, İbrahim Çavuş, Črtomir Podlipnik, Kor Yereli, Ahmet Özbilgin, Bilge Debeleç-Bütüner, Vildan Alptüzün   +10 more
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Pteridine reductase (PTR1): initial structure-activity relationships studies of potential leishmanicidal arylindole derivatives compounds

SAR and QSAR in Environmental Research, 2023
Leishmaniasis is a public health concern, especially in Brazil and India. The drugs available for therapy are old, cause toxicity and have reports of resistance. Therefore, this paper aimed to carry out initial structure-activity relationships (applying molecular docking and dynamic simulations) of arylindole scaffolds against the pteridine reductase ...
João Vitor Silva, S. SUEYOSHI, Timothy J. Snape, Sohan Lal, Jeanine Giarolla   +4 more
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Pteridine reductase (PTR1); dihydrofolate reductase (DHFR) [PDF]

Science-Business eXchange, 2011
In vitro studies identified antifolate inhibitors ofLeishmania major Ptr1 that could be used withDhfr inhibitors to help treat parasitic infection. Incultured L. major, five Ptr1-targeting compoundsshowed efficacy against the parasite in combinationwith the Dhfr inhibitor pyrimethamine.
COSTI, Maria Paola, Wade R.
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Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives [PDF]

BMC Chemistry
Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesized and their structures were verified by ...
Halefom Gebreselasse Berhe, Yihenew Simegniew Birhan, Botros Youssef Beshay, Huda Jawad Habib, Ariaya Hymete, Adnan Ahmed Bekhit   +5 more
doaj   +2 more sources

The Ralstonia pseudosolanacearum effector RipE1 is recognized at the plasma membrane by NbPtr1, the Nicotiana benthamiana homologue of Pseudomonas tomato race 1. [PDF]

Mol Plant Pathol, 2023
In Nicotiana benthamiana, the homologue of Pseudomonas tomato race 1 (NbPtr1) recognizes the conserved plasma membrane‐localized Ralstonia pseudosolanacearum effector RipE1 and triggers immunity. Abstract The bacterial wilt disease caused by soilborne bacteria of the Ralstonia solanacearum species complex (RSSC) threatens important crops worldwide ...
Kim B, Kim I, Yu W, Li M, Kim H, Ahn YJ, Sohn KH, Macho AP, Segonzac C.   +8 more
europepmc   +2 more sources

Proteomic analysis of metacyclogenesis in Leishmania infantum wild-type and PTR1 null mutant

EuPA Open Proteomics, 2014
AbstractThe parasite Leishmania exhibits a dimorphic life cycle with promastigotes found in the insect vector and amastigotes residing within mammalian macrophages. In the insect, promastigotes undergo metacyclogenesis with two main stages, the procyclic and metacyclic stages.
Wilfried Moreira, Danielle Légaré, Gina Racine, Gaétan Roy, Marc Ouellette   +4 more
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Inhibition of pteridine reductase 1 (PTR1) expression in Leishmania promastigotes using a full-length antisense construct [PDF]

Nature Precedings, 2009
AbstractLeishmania exhibit many unusual features, one of which is the pteridine metabolic pathway essential for the growth for these parasites. Leishmania have evolved a complex and versatile pteridine salvage network capable of scavenging a wide array of conjugated and unconjugated pteridines. The L.
Farnaz Kheirandish, Mojgan Bandehpour, Nushin Davoudi, Nariman Mosaffa, Mahboudi Fereydoun, Bahram Kazemi, Ali Haghighi, Mehdi Mohebali   +7 more
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