Results 31 to 40 of about 14,132 (182)

Structure of pteridine reductase (PTR1) fromTrypanosoma brucei [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2006
P. K. Fyfe, A. Dawson, F. Gibellini, K. McLuskey, N. Sienkiewicz, A. H. Fairlamb, W. N. Hunter   +6 more
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The core effector RipE1 of Ralstonia solanacearum interacts with and cleaves Exo70B1 and is recognized by the Ptr1 immune receptor [PDF]

, 2022
AbstractRalstonia solanacearumdepends on numerous virulence factors, also known as effectors, to promote disease in a wide range of economically important host plants. Although some of these effectors have been characterized, none have yet been shown to target the host’s secretion machinery.
Dimitra Tsakiri, Konstantinos Kotsaridis, Sotiris Marinos, Vassiliki A. Michalopoulou, Michael Kokkinidis, Panagiotis F. Sarris   +5 more
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Expression analysis of DHFR and PTR1 genes in Leishmania major exposed to olive leaf extract

South African Journal of Botany, 2023
Elnaz Bafandeh, Farnaz Kheirandish, Seyedeh Zeinab Hosseini, Saeed Veiskarami, Marzieh Rashidipour, Bahram Kazemi, Atiyeh Darbandi, Shirzad Fallahi, Arian Karimi Rouzbahani   +8 more
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Corrigendum to: Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities [PDF]

New Phytologist

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Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Pharmaceuticals, 2021
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi   +8 more
doaj   +1 more source

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Pharmaceuticals, 2021
Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatments of
Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi   +10 more
doaj   +1 more source

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

Molecules, 2021
The parasite Trypanosoma brucei (T. brucei) is responsible for human African trypanosomiasis (HAT) and the cattle disease “Nagana” which to this day cause severe medical and socio-economic issues for the affected areas in Africa.
Katharina Possart, Fabian C. Herrmann, Joachim Jose, Maria P. Costi, Thomas J. Schmidt   +4 more
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Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

PLoS Neglected Tropical Diseases, 2021
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by
Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette   +2 more
doaj   +1 more source

Design of 2-aminobenzothiazole derivatives targeting trypanosomatid PTR1 by a multidisciplinary fragment-based approach [PDF]

Pteridine reductase 1 (PTR1) is a key folate pathway enzyme of pathogenic trypanosomatids that reduces biopterin to dihydro- and tetrahydrobiopterin. It is a promising target for drug design against diseases such as sleeping sickness or leishmaniases. Amongst known PTR1 inhibitors, 2-aminobenzothiazole derivatives that target the PTR1 biopterin pocket ...
Joanna Panecka-Hofman, Pasquale Linciano, Ina Pöhner, Edyta Dyguda‐Kazimierowicz, Wiktoria Jedwabny, Giacomo Landi, Nuno Santarém, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Rosaria Luciani, Stefania Ferrari, Stefano Mangani, Cecilia Pozzi, Anabela Cordeiro‐da‐Silva, Sheraz Gul, Maria Paola Costi, Rebecca C. Wade   +17 more
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PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major [PDF]

Current Genetics, 2009
Leishmania must survive oxidative stress, but lack many classical antioxidant enzymes and rely heavily on trypanothione-dependent pathways. We used forward genetic screens to recover loci mediating oxidant resistance via overexpression in Leishmania major, which identified pteridine reductase 1 (PTR1). Comparisons of isogenic lines showed ptr1 (-) null
Bakela Nare, Levi A. Garraway, Tim J. Vickers, Stephen M. Beverley   +3 more
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