Results 41 to 50 of about 14,132 (182)

Diterpenos de Núcleo Kaurano como Inhibidores de la PTR1 de Leishmania: un Estudio In-Silico

Revista Facultad de Ciencias Básicas, 2013
<p>La pteridina reductasa-1 (PTR1) ha sido descubierta como la responsable de la reducción de la susceptibilidad a antifolatos (e.g., metotrexato) de parásitos tripanosómicos, lo cual la ha convertido en un objetivo quimioterapeútico. Por esta razón, trece diterpenos conocidos, de núcleo kaurano, fueron evaluados <em>in silico </em> ...
Luisa L. Ordúz-Díaz, Freddy A. Bernal, Ericsson Coy‐Barrera   +2 more
openalex   +3 more sources

The Ptr1 locus of Solanum lycopersicoides confers resistance to race 1 strains of Pseudomonas syringae pv. tomato and to Ralstonia pseudosolanacearum by recognizing the type III effectors AvrRpt2/RipBN [PDF]

, 2019
AbstractRace 1 strains of Pseudomonas syringae pv. tomato, which causes bacterial speck disease of tomato, are becoming increasingly common and no simply-inherited genetic resistance to such strains is known. We discovered that a locus in Solanum lycopersicoides, termed Pseudomonas tomato race 1 (Ptr1), confers resistance to race 1 Pst strains by ...
Carolina Mazo‐Molina, Samantha Mainiero, Sarah R. Hind, Christine M. Kraus, Mishi Vachev, Felicia Maviane-Macia, Magdalen Lindeberg, Surya Saha, Susan R. Strickler, Ari Feder, James J. Giovannoni, Christine D. Smart, Nemo Peeters, Gregory B. Martin   +13 more
  +9 more sources

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium berghei infected mice.
Adnan A. Bekhit, Eskedar T. Lodebo, Ariaya Hymete, Hanan M. Ragab, Salma A. Bekhit, Kikuko Amagase, Afnan Batubara, Mohammed A. S. Abourehab, Alaa El-Din A. Bekhit, Tamer M. Ibrahim   +9 more
doaj   +1 more source

In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase

Molecules, 2023
The parasites Trypanosoma brucei (Tb) and Leishmania major (Lm) cause the tropical diseases sleeping sickness, nagana, and cutaneous leishmaniasis. Every year, millions of humans, as well as animals, living in tropical to subtropical climates fall victim
Katharina Possart, Fabian C. Herrmann, Joachim Jose, Thomas J. Schmidt   +3 more
doaj   +1 more source

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

Molecules, 2021
The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging.
Chonny Herrera-Acevedo, Areli Flores-Gaspar, Luciana Scotti, Francisco Jaime Bezerra Mendonça-Junior, Marcus Tullius Scotti, Ericsson Coy-Barrera   +5 more
doaj   +1 more source

Engineering effector‐triggered immunity in rice: Obstacles and perspectives

Plant, Cell &Environment, Volume 46, Issue 4, Page 1143-1156, April 2023., 2023
Abstract Improving rice immunity is one of the most effective approaches to reduce yield loss by biotic factors, with the aim of increasing rice production by 2050 amidst limited natural resources. Triggering a fast and strong immune response to pathogens, effector‐triggered immunity (ETI) has intrigued scientists to intensively study and utilize the ...
Kieu Thi Xuan Vo, Qi Yi, Jong‐Seong Jeon   +2 more
wiley   +1 more source

Global distribution of treatment resistance gene markers for leishmaniasis

Journal of Clinical Laboratory Analysis, Volume 36, Issue 8, August 2022., 2022
Geographical distribution of resistant biomarkers gene based on studies carried out on clinical‐resistant isolate. Abstract Background Pentavalent antimonials (Sb(V)) such as meglumine antimoniate (Glucantime®) and sodium stibogluconate (Pentostam®) are used as first‐line treatments for leishmaniasis, either alone or in combination with second‐line ...
Samira Salari, Mehdi Bamorovat, Iraj Sharifi, Pooya Ghasemi Nejad Almani   +3 more
wiley   +1 more source

A Solanum lycopersicoides reference genome facilitates insights into tomato specialized metabolism and immunity

The Plant Journal, Volume 110, Issue 6, Page 1791-1810, June 2022., 2022
SUMMARY Wild relatives of tomato are a valuable source of natural variation in tomato breeding, as many can be hybridized to the cultivated species (Solanum lycopersicum). Several, including Solanum lycopersicoides, have been crossed to S. lycopersicum for the development of ordered introgression lines (ILs), facilitating breeding for desirable traits.
Adrian F. Powell, Ari Feder, Jie Li, Maximilian H.‐W. Schmidt, Lance Courtney, Saleh Alseekh, Emma M. Jobson, Alexander Vogel, Yimin Xu, David Lyon, Kathryn Dumschott, Marcus McHale, Ronan Sulpice, Kan Bao, Rohit Lal, Asha Duhan, Asis Hallab, Alisandra K. Denton, Marie E. Bolger, Alisdair R. Fernie, Sarah R. Hind, Lukas A. Mueller, Gregory B. Martin, Zhangjun Fei, Cathie Martin, James J. Giovannoni, Susan R. Strickler, Björn Usadel   +27 more
wiley   +1 more source

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

Acta Crystallographica Section F, Volume 78, Issue 4, Page 170-176, April 2022., 2022
The high‐resolution structure of Leishmania major pteridine reductase 1 in complex with its cofactor NADP+/NADPH and its substrate folic acid is reported. It provides insight into the active‐site rearrangements that occur during the catalytic process.Pteridine reductase 1 (PTR1) is a key enzyme of the folate pathway in protozoan parasites of the genera
Lucia Dello Iacono, Flavio Di Pisa, Stefano Mangani   +2 more
wiley   +1 more source

TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms

Cancer Science, Volume 113, Issue 4, Page 1393-1405, April 2022., 2022
TRAF6 regulates the LPS‐NF‐kappaB‐VEGF‐C signal pathway to effect colorectal cancer lymphangiogenesis, growth and invasion via a ubiquitination mechanism. Our results provide new insights into the mechanism of colorectal cancer metastasis, which may provide novel ideas for tumor immunotherapy. Abstract Tumor necrosis factor receptor‐associated factor‐6
Zhu Guangwei, Cheng Zhibin, Wang Qin, Lin Chunlin, Lin Penghang, He Ruofan, Chen Hui, Robert M. Hoffman, Ye Jianxin   +8 more
wiley   +1 more source