Results 51 to 60 of about 14,132 (182)

Molecular Cloning and Expression of Iranian Leishmania major Pteridine Reductase 1 [PDF]

Iranian Journal of Parasitology, 2008
Background: Leishmaniasis is an endemic disease in 88 countries. Reports on Leishmania drug resistance are growing in number. The mechanism of unresponsiveness against glucantime in Iranian cutaneous leishmaniasis has not yet been characterized. To begin
N Mosaffa, M Mohebali, F Mahboudi, A Haghighi, M Bandehpour, F Kheirandish, B Kazemi   +6 more
doaj   +2 more sources

In vitro antileishmanial activity and molecular docking studies of lupeol and monostearin, isolated from Parkia biglobosa

Scientific African, 2023
Parkia biglobosa (Leguminosae) is used traditionally for managing leishmaniasis. However, there are no reports of the antileishmanial constituents from the plant.
Thomas Osafo, Trudy Janice Philips, Abigail Kusiwaa Adomako, Lawrence Sheringham Borquaye, Edmund Ekuadzi, Regina Appiah-Opong, Rita Akosua Dickson   +6 more
doaj   +1 more source

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Abedawn I. Khalaf, Addie M., Arcari J. T., Baker N., Barrett M. P., Barrett M. P., Bridges D. J., Brun R., Bursavich M. G., Carter N. S., Cavazzuti A., Colin J. Suckling, Colin L. Gibson, Creek D. J., Dawson A., Dincer S., Federica Giordani, Gangjee A., Gibson C. L., Gourley D. G., Judith K. Huggan, Kaspersen S. J., Keri L. Barrack, Kirsten Stewart, Le Brazidec J.-Y., Matovu E., Michael P. Barrett, Mohamed M. S., Mpamhanga C. P., Pui Ee Wong, Raz B., Sienkiewicz N., Simarro P. P., Spinks D., Tari L. W., Taylor E. C., Tessier P. R., Trzoss M., Tulloch L. B., William N. Hunter, Xie H., Zhu G.   +41 more
core   +5 more sources

Universal Compressed Text Indexing [PDF]

, 2018
The rise of repetitive datasets has lately generated a lot of interest in compressed self-indexes based on dictionary compression, a rich and heterogeneous family that exploits text repetitions in different ways. For each such compression scheme, several
Navarro, Gonzalo, Prezza, Nicola
core   +2 more sources

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. [PDF]

Proceedings of the National Academy of Sciences, 1994
Trypanosomatid protozoans are pterin auxotrophs, a finding noted decades ago which heralded the discovery of key metabolic roles played by pteridines in eukaryotes. We have now identified the enzyme mediating unconjugated pteridine salvage in the human parasite Leishmania major, PTR1 (pteridine reductase 1, formerly hmtxr or ltdh).
Alexandre Ribeiro Bello, Bakela Nare, D. Freedman, Larry W. Hardy, Stephen M. Beverley   +4 more
openalex   +4 more sources

Chemical Constituents from Uapaca guineensis (Phyllanthaceae), and the Computational Validation of Their Antileishmanial and Anti‐inflammatory Potencies

Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022
From the chemical investigations of the root bark of Uapaca guineensis, nine distinct compounds (1–9) have been isolated and characterized as lupeol, betulin, betulinic acid, β‐amyryl acetate, physcion, quercetin, rutin, β‐sitosterol, and β‐sitosterol‐3‐O‐β‐D‐glucopyranoside, respectively.
Gervais Mouthé Happi, Mireille Towa Yimtchui, Sikiru Akinyeye Ahmed, Shina Salau, Liliane Clotilde Dzouemo, Klev Gaïtan Sikam, Jean Duplex Wansi, Ashutosh Sharma   +7 more
wiley   +1 more source

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity [PDF]

, 2017
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold.
Alcantara, Laura M, Behrens, Birte, Borsari, Chiara, Cordeiro-da-Silva, Anabela, Costi, Maria Paola, Dello Iacono, Lucia, Di Pisa, Flavio, Ferrari, Stefania, Fontana, Vanessa, Freitas-Junior, Lucio H, Gul, Sheraz, Kuzikov, Maria, Landi, Giacomo, Mangani, Stefano, Moraes, Carolina B, Poehner, Ina, Pozzi, Cecilia, Santarem, Nuno, Santucci, Matteo, Wade, Rebecca C   +19 more
core   +3 more sources

Spatiotemporal patterns of intracellular Ca2+ signalling govern hypo‐osmotic stress resilience in marine diatoms

New Phytologist, Volume 230, Issue 1, Page 155-170, April 2021., 2021
Summary Diatoms are globally important phytoplankton that dominate coastal and polar‐ice assemblages. These environments exhibit substantial changes in salinity over dynamic spatiotemporal regimes. Rapid sensory systems are vital to mitigate the harmful consequences of osmotic stress.
Katherine E. Helliwell, Friedrich H. Kleiner, Hayley Hardstaff, Abdul Chrachri, Trupti Gaikwad, Deborah Salmon, Nicholas Smirnoff, Glen L. Wheeler, Colin Brownlee   +8 more
wiley   +1 more source

Exploring Different Drug Targets Responsible for the Inhibitory Activity of N, N′-Substituted Diamine Derivatives in Leishmania

Engineering Proceedings, 2023
The genome sequence of Leishmania has given rise to diverse novel drug targets, and their identification remains the first step in drug discovery. This study aims to identify the possible anti-leishmanicidal activity target(s) of N1, N4-[dibenzylbutane-4′
Ikenna F. Ezema, Victor C. Akwu, Obinna K. Didigwu, Jude E. Ogbonna, Augustine C. Ugwu, Charles O. Nnadi   +5 more
doaj   +1 more source

Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome [PDF]

, 2018
The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids.
Boesche, Markus, Drewes, Gerard, Fairlamb, Alan, Ghidelli-Disse, Sonja, Gilbert, Ian, Ong, Han, Thomas, Michael, Tinti, Michele, Urbaniak, Michael, Webster, Lauren, Wyllie, Susan   +10 more
core   +11 more sources